A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 2, 2010, Pages 404-413

  Evers, Alex S ^a   Chen, Zi Wei ^a   Manion, Brad D ^a   Han, Mingcheng ^a   Jiang, Xin ^a   Darbandi Tonkabon, Ramin ^a   Kable, Tristan ^a   Bracamontes, John ^a   Zorumski, Charles F ^a   Mennerick, Steven ^a   Steinbach, Joe Henry ^a   Covey, Douglas F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3ALPHA,5BETA,17BETA)3 HYDROXY 18 NORANDROSTANE 17 CARBONITRILE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; NORSTEROID; PARTIAL AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN MEMBRANE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; ELECTROPHYSIOLOGY; FEMALE; INTROSPECTION; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RIGHTING REFLEX; STEROID BINDING; STRUCTURE ACTIVITY RELATION; TADPOLE;

ACTION POTENTIALS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BRAIN; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE POTENTIALS; MICE; MICE, INBRED BALB C; NITRILES; NORANDROSTANES; OOCYTES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 77951029856     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.164079     Document Type: Article

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