Mutations of the GABA-A receptor α1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids

Molecular Pharmacology

Volumn 74, Issue 3, 2008, Pages 614-627

  Akk, Gustav ^a   Li, Ping ^a   Bracamontes, John ^a   Reichert, David E ^b   Covey, Douglas F ^a   Steinbach, Joe Henry ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 PIPERIDINESULFONIC ACID; ASPARAGINE; GABA A RECEPTOR ALPHA 1 SUBUNIT; GLUTAMINE; MEMBRANE PROTEIN; NEUROSTEROID; PREGNENOLONE SULFATE; RECEPTOR PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; GENE MUTATION; HUMAN; HUMAN CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; GAMMA-AMINOBUTYRIC ACID; HUMANS; ION CHANNEL GATING; MUTANT PROTEINS; MUTATION; PIPERIDINES; PREGNANETRIOL; PREGNANOLONE; PREGNENOLONE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; SERINE; STEROIDS; TRYPTOPHAN;

EID: 50449086734     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.048520     Document Type: Article

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