MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1α

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 9, 2011, Pages

  Leone, Vincenza ^a,b   D'Angelo, Daniela ^a   Rubio, Ileana ^c   De Freitas, Paula Mussnich ^a   Federico, Antonella ^a,b   Colamaio, Marianna ^a,b   Pallante, Pierlorenzo ^a   Medeiros Neto, Geraldo ^c   Fusco, Alfredo ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b European School of Molecular Medicine   (Italy)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CYCLIN D2; MICRORNA; MICRORNA 1; PROPYLTHIOURACIL; STROMAL CELL DERIVED FACTOR 1; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; OPEN READING FRAME; PHASE TRANSITION; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; THYROID CANCER; THYROID CARCINOMA; THYROID FOLLICULAR CARCINOMA; THYROID HYPERPLASIA;

ADENOMA; ANIMALS; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL12; CYCLIN D2; DOWN-REGULATION; HUMANS; MICE; MICRORNAS; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; THYROID GLAND; THYROID NEOPLASMS;

EID: 80052550487     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0345     Document Type: Article

References (37)

1. Bartel D.P. 2004 MicroRNA: Genomics, biogenesis, mechanism, and function. Cell 116:281-297
2. Ambros V. 2004 The functions of animal microRNA. Nature 431:350-355
3. Lewis B.P., Burge C.B., Bartel D.P. 2005 Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20 (Pubitemid 40094598)
4. Kim V.N. 2005 MicroRNA biogenesis: Coordinated cropping and dicing. Nat Rev Mol Cell Biol 6:376-385 (Pubitemid 40637855)
5. Taganov K.D., Boldin M.P., Baltimore D. 2007 MicroRNA and immunity: Tiny players in a big field. Immunity 26:133-137 (Pubitemid 46329443)
6. Stefani G., Slack F.J. 2008 Small non-coding RNA in animal development. Nat Rev Mol Cell Biol 9:219-230 (Pubitemid 351301826)
7. Hwang H.W., Mendell J.T. 2007 MicroRNA in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96(Suppl):R40-R44
8. Pallante P., Visone R., Ferracin M., Ferraro A., Berlingieri M.T., Troncone G., Chiappetta G., Liu C.G., Santoro M., Negrini M., Croce C.M., Fusco A. 2006 MicroRNA deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer 13:497-508 (Pubitemid 43886672)
9. Visone R., Russo L., Pallante P., De Martino I., Ferraro A., Leone V., Borbone E., Petrocca F., Alder H., Croce C.M., Fusco A. 2007 MicroRNA (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer 14:791-798 (Pubitemid 350074067)
10. Visone R., Pallante P., Vecchione A., Cirombella R., Ferracin M., Ferraro A., Volinia S., Coluzzi S., Leone V., Borbone E., Liu C.G., Petrocca F., Troncone G., Calin G.A., Scarpa A., Colato C., Tallini G., Santoro M., Croce C.M., Fusco A. 2007 Specific microRNA are downregulated in human thyroid anaplastic carcinomas. Oncogene 26:7590-7595 (Pubitemid 350207711)
11. Nasser M.W., Datta J., Nuovo G., Kutay H., Motiwala T., Majumder S., Wang B., Suster S., Jacob S.T., Ghoshal K. 2008 Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicininduced apoptosis by miR-1. J Biol Chem 283:33394-33405
12. Datta J., Kutay H., Nasser M.W., Nuovo G.J., Wang B., Majumder S., Liu C.G., Volinia S., Croce C.M., Schmittgen T.D., Ghoshal K., Jacob S.T. 2008 Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68:5049-5058
13. Ambs S., Prueitt R.L., Yi M., Hudson R.S., Howe T.M., Petrocca F., Wallace T.A., Liu C.G., Volinia S., Calin G.A., Yfantis H.G., Stephens R.M., Croce C.M. 2008 Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 68:6162-6170
14. Yan D., Dong Xda E., Chen X., Wang L., Lu C., Wang J., Qu J., Tu L. 2009 MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development. J Biol Chem 284:29596-29604
15. Pallante P., Berlingieri M.T., Troncone G., Kruhoffer M., Orntoft T.F., Viglietto G., Caleo A., Migliaccio I., Decaussin-Petrucci M., Santoro M., Palombini L., Fusco A. 2005 UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas. Br J Cancer 93:464-471
16. Fusco A., Berlingieri M.T., Di Fiore P.P., Portella G., Grieco M., Vecchio G. 1987 One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes. Mol Cell Biol 7:3365-3370
17. Berlingieri M.T., Portella G., Grieco M., Santoro M., Fusco A. 1988 Cooperation between the polyomavirus middle-T-antigen gene and the human c-myc oncogene in a rat thyroid epithelial differentiated cell line: Model of in vitro progression. Mol Cell Biol 8:2261-2266
18. De Falco V., Guarino V., Avilla E., Castellone M.D., Salerno P., Salvatore G., Faviana P., Basolo F., Santoro M., Melillo R.M. 2007 Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer. Cancer Res 67:11821-11829
19. De Martino I., Visone R., Wierinckx A., Palmieri D., Ferraro A., Cappabianca P., Chiappetta G., Forzati F., Lombardi G., Colao A., Trouillas J., Fedele M., Fusco A. 2009 HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. Cancer Res 69:1844-1850
20. Livak K.J., Schmittgen T.D. 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT. Methods 25:402-408 (Pubitemid 34164012)
21. Teicher B.A., Fricker S.P. 2010 CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16:2927-2931
22. Burger J.A., Kipps T.J. 2006 CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107:1761-1767 (Pubitemid 43289351)
23. Balkwill F. 2004 The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 14:171-179 (Pubitemid 38586742)
24. Zushi Y., Noguchi K., Hashitani S., Sakurai K., Segawa E., Takaoka K., Toyohara Y., Tanaka N., Kishimoto H., Urade M. 2008 Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck. Int J Oncol 33:1133-1139
25. Chaudary N., Hill R.P. 2009 Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors. Lab Invest 89:587-596
26. Cronin P.A., Wang J.H., Redmond H.P. 2010 Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4. BMC Cancer 10:225
27. Guo Z., Cai S., Fang R., Chen H., Du J., Tan Y., Ma W., Hu H., Cai S., Liu Y. 2007 The synergistic effects of CXCR4 and EGFR on promoting EGF-mediated metastasis in ovarian cancer cells. Colloids Surf B Biointerfaces 60:1-6 (Pubitemid 47302287)
28. Aust G., Steinert M., Kiessling S., Kamprad M., Simchen C. 2001 Reduced expression of stromal-derived factor 1 in autonomous thyroid adenomas and its regulation in thyroid-derived cells. J Clin Endocrinol Metab 86:3368-3376 (Pubitemid 32673510)
29. Hwang J.H., Hwang J.H., Chung H.K., Kim D.W., Hwang E.S., Suh J.M., Kim H., You K.H., Kwon O.Y., Ro H.K., Jo D.Y., Shong M. 2003 CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells. J Clin Endocrinol Metab 88:408-416 (Pubitemid 36115196)
30. Castellone M.D., Guarino V., De Falco V., Carlomagno F., Basolo F., Faviana P., Kruhoffer M., Orntoft T., Russell J.P., Rothstein J.L., Fusco A., Santoro M., Melillo R.M. 2004 Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene 23:5958-5967 (Pubitemid 39093540)
31. Melillo R.M., Castellone M.D., Guarino V., De Falco V., Cirafici A.M., Salvatore G., Caiazzo F., Basolo F., Giannini R., Kruhoffer M., Orntoft T., Fusco A., Santoro M. 2005 The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J Clin Invest 115:1068-1081 (Pubitemid 40489412)
32. Ganju R.K., Brubaker S.A., Meyer J., Dutt P., Yang Y., Qin S., Newman W., Groopman J.E. 1998 The Δ-chemokine, stromal cell-derived factor- 1Δ, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 273:23169-23175 (Pubitemid 28417500)
33. Peng S.B., Peek V., Zhai Y., Paul D.C., Lou Q., Xia X., Eessalu T., Kohn W., Tang S. 2005 Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1Δ/CXCR4-mediated migration of epitheloid carcinoma cells. Mol Cancer Res 3:227-236 (Pubitemid 40525333)
34. Gonzälez H.E., Leiva A., Tobar H., Böhmwald K., Tapia G., Torres J., Mosso L.M., Bueno S.M., Gonzalez P., Kalergis A.M., Riedel C.A. 2009 Altered chemokine receptor expression in papillary thyroid cancer. Thyroid 19:957-965
35. Bleul C.C., Fuhlbrigge R.C., Casasnovas J.M., Aiuti A., Springer T.A. 1996 A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 184:1101-1109 (Pubitemid 26313567)
36. Yasuoka H., Kodama R., Hirokawa M., Takamura Y., Miyauchi A., Sanke T., Nakamura Y. 2008 CXCR4 expression in papillary thyroid carcinoma: Induction by nitric oxide and correlation with lymph node metastasis. BMC Cancer 8:274
37. Trusolino L., Bertotti A., Comoglio P.M. 2010 MET signalling: Principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 11:834-848