Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation

Biology of Blood and Marrow Transplantation

Volumn 11, Issue 5, 2005, Pages 321-334

  Le Blanc, Katarina ^a   Ringdén, Olle ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allogeneic hematopoietic stem cell transplantation; Graft versus host disease; Immune response; Mesenchymal stem cells

Indexed keywords

CELL ADHESION MOLECULE; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INTERCELLULAR ADHESION MOLECULE 1;

ACUTE GRANULOCYTIC LEUKEMIA; APLASTIC ANEMIA; APOPTOSIS; BREAST CANCER; CELL CULTURE; CELL DIFFERENTIATION; CELL INTERACTION; CELL ISOLATION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE SYSTEM; IMMUNOBIOLOGY; IMMUNOMODULATION; IN VITRO STUDY; INBORN ERROR OF METABOLISM; LYMPHOCYTE PROLIFERATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MOLECULAR MECHANICS; OSTEOGENESIS IMPERFECTA; REVIEW;

FORECASTING; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; TRANSPLANTATION IMMUNOLOGY;

EID: 17444379357     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbmt.2005.01.005     Document Type: Review

References (148)

1. A.J. Friedenstein K.V. Petrakova A.I. Kurolesova et al. Heterotypic transplants of bone marrow: Analysis of precursor cells for osteogenic and hematopoietic tissues Transplantation 6 1968 230-247
2. A.J. Friedenstein Precursor cells of mechanocytes Int Rev Cytol 47 1976 327-345
3. A.J. Friedenstein R.K. Chailakhyan U.V. Gerasimov Bone marrow osteogenic stem cells: In vitro cultivation and transplantation into diffusion chambers Cell Tissue Kinet 20 1987 263-272
4. M.E. Owen A.J. Friedenstein Stromal stem cell: Marrow-derived osteogenic precursors SIBA Found Symp 136 1988 42-60
5. D. De Ugarte K. Morizono A. Elbarbary et al. Comparison of multilineage cells from human adipose tissue and bone marrow Cells Tissues Organs 174 2003 101-109
6. C. Campagnoli I.A. Roberts S. Kumar P.R. Bennett I. Bellantuono N.M. Fisk Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow Blood 98 2001 2396-2402
7. W.A. Noort A.B. Kruysselbrink P.S. in't Anker et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34+ cells in NOD/SCID mice Exp Hematol 30 2002 870-878
8. A. Erices P. Conget J.J. Minguell Mesenchymal progenitor cells in human umbilical cord blood Br J Haematol 109 2000 235-242
9. S.E. Haynesworth J. Goshima V.M. Goldberg A.I. Caplan Characterization of cells with osteogenic potential from human marrow Bone 13 1992 81-88
10. M.F. Pittenger A.M. Mackay S.C. Beck et al. Multilineage potential of human mesenchymal stem cells Science 284 1999 143-147
11. D.J. Prockop Marrow stromal cells as stem cells for non-hematopoietic tissues Science 276 1997 71-74
12. S.P. Bruder D.J. Fink A.I. Caplan Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy J Cell Biochem 56 1994 283-294
13. S.P. Bruder K.H. Kraus V.M. Goldberg S. Kadiyala The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects J Bone Joint Surg Am 80 1998 985-996
14. S.P. Bruder A.A. Kurth M. Shea W.C. Hayes N. Jaiswal S. Kadiyala Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells J Orthop Res 16 1998 155-162
15. D.A. Grande S.S. Southerland R. Manji D.W. Pate S.E. Schwartz P.A. Lucas Repair of articular cartilage defects using mesenchymal stem cells Tissue Eng 1 1995 345-353
16. S. Wakitani T. Goto S.J. Pineda et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage J Bone Joint Surg Am 76 1994 579-592
17. R.G. Young D.L. Butler W. Weber S.L. Gordon D.J. Fink Mesenchymal stem cell-based repair of rabbit Achilles tendon Trans Orthop Res Soc 22 1997 249
18. C. De Bari F. Dell'Accio F. Vandenabeele J.R. Vermeesch J.M. Raymackers F.P. Luyten Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane J Cell Biol 160 2003 909-918
19. S. Makino K. Fukuda S. Miyoshi et al. Cardiomyocytes can be generated from marrow stromal cells in vitro J Clin Invest 103 1999 697-705
20. J.S. Wang D. Shum-Tim J. Galipeau E. Chedrawy N. Eliopoulos R.C.J. Chiu Marrow stromal cells for cellular cardiomyoplasty: Feasibility and clinical advantages J Thorac Cardiovasc Surg 120 2000 999-1006
21. J.S. Wang D. Shum-Tim E. Chedrawy R.C.J. Chiu The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications J Thorac Cardiovasc Surg 122 2001 699-705
22. C. Toma M.F. Pittenger K.S. Cahill B.J. Byrne P.D. Kessler Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart Circulation 105 2002 93-98
23. M. Rydén A. Dicker C. Götherström et al. Functional characterization of human mesenchymal stem cell-derived adipocytes Biochem Biophys Res Commun 311 2003 391-397
24. M. Di Nicola C. Carlostella M. Magni et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli Blood 99 2002 3838-3843
25. A. Bartholomew C. Sturgeon M. Siatskas et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo Exp Hematol 30 2002 42-48
26. K. Le Blanc C. Tammik B. Sundberg S. Haynesworth O. Ringdén Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility system Scand J Immunol 57 2003 11-20
27. W.T. Tse J.D. Pendleton W.M. Beyer M.C. Egalka E.C. Guinan Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation Transplantation 75 2003 389-397
28. M. Krampera S. Glennie J. Dyson et al. Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide Blood 101 2003 3722-3729
29. B. Maitra E. Szekely K. Gjini et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation Bone Marrow Transplant 33 2004 597-604
30. H.J. Deeg B.R. Blazar B.J. Bolwell et al. Treatment of steroid-refractory acute graft-versus-host disease with anti-CD 147 monoclonal antibody ABX-CBL Blood 98 2002 2052-2058
31. R. Storb E.D. Thomas Graft-versus-host disease in dog and man: The Seattle experience Immunol Rev 88 1985 215-238
32. O. Ringdén B. Nilsson Death by graft-versus-host disease associated with HLA mismatch, high recipient age, low marrow cell dose, and splenectomy Transplantation 40 1985 39-44
33. O. Ringdén Management of graft-versus-host disease Eur J Haematol 51 1993 1-12
34. P.J. Martin G. Schoch L. Fisher et al. A retrospective analysis of therapy for acute graft-versus-host disease: Initial treatment Blood 76 1990 1464-1472
35. D. Weisdorf R. Haake B. Blazar et al. Treatment of moderate/severe acute graft-versus-host disease after allogeneic bone marrow transplantation: an analysis of clinical risk features and outcome Blood 75 1990 1024-1030
36. P. Herve J. Wijdenes J.P. Bergerat et al. Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10) Blood 75 1990 1017-1023
37. J. Aschan Treatment of moderate to severe acute graft-versus-host disease: A retrospective analysis Bone Marrow Transplant 14 1994 601-607
38. C. Anasetti J.A. Hansen T.A. Waldmann et al. Treatment of acute graft-versus-host disease with humanized anti-Tac: An antibody that binds to the interleukin-2 receptor Blood 84 1994 1320-1327
39. P.L. McCarthy L. Williams M. Harris-Bacile et al. A clinical phase I/II study of recombinant human interleukin-1 receptor in glucocorticoid-resistant graft-versus-host disease Transplantation 62 1996 626-631
40. A.L. Benito T. Furlong P.J. Martin et al. Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease Transplantation 72 2001 1924-1929
41. G. Kobbe P. Schneider U. Rohr et al. Treatment of severe steroid refractory acute graft-versus-host disease with infliximab, a chimeric human/mouse antiTNFalpha antibody Bone Marrow Transplant 28 2001 47-49
42. M. Remberger J. Aschan L. Barkholt J. Tollemar O. Ringdén Treatment of severe acute graft-versus-host disease with anti-thymocyte globulin Clin Transplant 15 2001 147-153
43. K. Le Blanc I. Rasmusson B. Sundberg et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 363 2004 1439-1441
44. H. Castro-Malaspina R.E. Gay G. Resnick et al. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny Blood 56 1980 289-301
45. P.J. Simmons B. Torok-Storb Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1 Blood 78 1991 55-62
46. S.P. Bruder N. Jaiswal S.E. Haynesworth Growth kinetics self renewal, and the osteogenic potential of purified human mesenchymal cells during extensive subcultivation and following cryopreservation J Cell Biochem 64 1997 278-294
47. E. Jones S. Kinsey A. English et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells Arthritis Rheum 46 2002 3349-3360
48. N. Tremain J. Korkko D. Ibberson G.C. Kopen C. DiGirolamo D. Phinney Micro SAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals nRNAs of multiple cell lineages Stem Cells 19 2001 408-418
49. A. Muralgia R. Cancedda R. Quattro Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model J Cell Sci 113 2000 1161-1166
50. C.M. DiGirolamo D. Stokes D. Colter D.G. Phinney R. Class D.J. Prockop Propagation and senescence of human marrow stromal cells in culture: A simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate Br J Haematol 107 1999 275-281
51. P.A. Conget J.J. Minguell Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells J Cell Physiol 181 1999 67-73
52. D.C. Colter R. Class C.M. DiGirolamo D.J. Prockop Rapid expansion of recycling stem cell in culture of plastic adherent cells from human bone marrow Proc Natl Acad Sci U S A 97 2000 3213-3218
53. D.C. Colter I. Sekiya D.J. Prockop Identification of subpopulation of rapidly self renewing and multipotential adult stem cell in colonies of human marrow stromal cells Proc Natl Acad Sci U S A 98 2001 7841-7845
54. I. Sekiya B.L. Larson J.R. Smith R. Pochampally J.G. Cui D.J. Prockop Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality Stem Cells 20 2002 530-541
55. I. Blazsek B. Delmas Marsalet S. Legras S. Marion D. Machover J.L. Misset Large scale recovery and characterization of stromal cell-associated primitive hematopoietic progenitor cells from filter-retained human bone marrow Bone Marrow Transplant 23 1999 647-657
56. M. Galotto G. Berisso L. Delfino et al. Stromal damage as a consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients Exp Hematol 27 1999 1460-1466
57. O. Koç C. Peters S. Raghavan et al. Bone marrow derived mesenchymal stem cells of patients with lysosomal and peroxisomal storage diseases remain host type following allogeneic bone marrow transplantation Exp Hematol 27 1999 1675-1681
58. D.P. Lennon S.E. Haynesworth S.P. Bruder et al. Development of a serum screen for mesenchymal progenitor cells from bone marrow In Vitro Cell Dev Biol 32 1996 602-611
59. A. Piersma R. Ploemacher K. Brockbank Transplantation of bone marrow fibroblastoid stromal cells in mice via the intravenous route Br J Haematol 54 1983 285-290
60. M. Ojeda-Uribe A. Brunot A. Lenat M. Legros Failure to detect spindle-shaped fibroblastoid cell progenitors in PBPC collections Acta Haematol 90 1993 139-143
61. M. Fernandez V. Simon G. Herrera C. Cao H. Del Favero J. Minguell Detection of stromal cells in peripheral blood progenitor cell collections from breast cancer patients Bone Marrow Transplant 20 1997 265-271
62. H. Lazarus S. Haynesworth S. Gerson A. Caplan Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) can not be recovered from peripheral blood progenitor cell collections J Hematother 6 1997 447-455
63. S.A. Wexler C. Donaldson P. Denning-Kendall C. Rice B. Bradley J.M. Hows Adult bone marrow is a rich source of human mesenchymal stem cells, but umbilical cord and mobilised adult blood are not Br J Haematol 121 2003 368-374
64. S.E. Haynesworth M.A. Baber A.I. Caplan Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies Bone 13 1992 69-80
65. R.J. Deans A.-M. Moseley Mesenchymal stem cells: Biology and potential clinical uses Exp Hematol 28 2000 875-884
66. F.P. Barry R.E. Boynton S. Haynesworth J. Murphy J. Zaia The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105) Biochem Biophys Res Commun 265 1999 134-139
67. F. Barry R. Boynton M. Murphy S. Haynesworth J. Zaia SH-3 and SH-4 antibodies recognized distinct epitopes on CD73 from human mesenchymal stem cells Biochem Biophys Res Commun 289 2001 519-524
68. C. Chichester M. Fernandez J. Minguel Extracellular matrix gene expression by human bone marrow stroma and by marrow fibroblasts Cell Adhes Commun 1 1993 93-99
69. S.E. Haynesworth M.A. Baber A.I. Caplan Characterization of the unique mesenchymal stem cell phenotype in vitro Trans Orthop Res Soc 20 1995 7-11
70. S. Azizi D. Stokes B. Augelli C. DiGirolamo D.J. Prockop Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts Proc Natl Acad Sci U S A 95 1998 3908-3913
71. M. Majumdar M. Keane-Moore D. Buyaner et al. Characterization and functionality of cell surface molecules on human mesenchymal stem cells J Biomed Sci 10 2003 228-241
72. M.K. Majumdar M.A. Thiede J.D. Mosca M. Moorman S.L. Gerson Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSC) and stromal cells J Cell Physiol 176 1998 57-66
73. D. De Ugarte Z. Alfonso P. Zuk et al. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow Immunol Lett 89 2003 267-270
74. G. Mbalaviele N. Jaiswal A. Meng L. Cheng C. Van Den Bos M. Thiede Human mesenchymal stem cells promote human osteoclast differentiation from CD34+ bone marrow hematopoietic progenitors Endocrinology 140 1999 3736-3743
75. L. Cheng P. Qasba P. Vanguri M.A. Thiede Human mesenchymal stem cells support megacaryocyte and pro-platelet formation from CD34+ hematopoietic progenitor cells J Cell Physiol 184 2000 58-59
76. S. Haynesworth M. Baber A. Caplan Cytokine expression by human marrow derived mesenchymal progenitor cells in vitro: Effect of dexamethasone and IL-1 alpha J Cell Physiol 166 1996 585-592
77. S. Neuss E. Becker M. Wöltje L. Tietze W. Jahnen-Dechent Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair and wound healing Stem Cells 22 2004 405-414
78. M.K. Majumdar V. Banks D.P. Peluso E.A. Morris Isolation, characterisation and chondrogenic potential of human bone marrow-derived multi-potential stromal cells J Cell Physiol 185 2000 98-106
79. K. Miyake I.L. Weisman J.S. Greenberger et al. Evidence for a role of the integrin VLA4 in lympho-hemopoiesis J Exp Med 173 1991 599-607
80. P.C. Kierney K. Dorshkind B-lymphocyte precursors and myeloid progenitors survive in diffusion chamber cultures but B-cell differentiation requires close association with stromal cells Blood 70 1987 1418-1424
81. M. Barda-Saad L.A. Rozenszajn A. Globerson A.S. Chang D. Zypori Selective adhesion of immature thymocytes to bone marrow stromal cells: relevance to T-cell lymphopoiesis Exp Hematol 24 1996 386-391
82. M. Barda-Saad L.A. Rozenszajn H. Ashush Y. Shav-Tal A.B. Nun D. Zipori Adhesion molecules involved in the interactions between early T-cells and mesenchymal bone marrow stromal cells Exp Hematol 27 1999 834-844
83. Y. Li H. Hisha M. Inaba et al. Evidence for migration of donor bone marrow stromal cells into recipient thymus after bone marrow transplantation plus bone grafts: A role for stromal cells in positive selection Exp Hematol 28 2000 950-960
84. K. Le Blanc C. Tammik C. Götherström E. Zetterberg O. Ringdén HLA-expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells Exp Hematol 31 2003 890-896
85. C. Götherström O. Ringdén C. Tammik E. Zetterberg M. Westgren K. Le Blanc Immunological properties of human fetal mesenchymal stem cells Am J Obstet Gynecol 190 2004 239-245
86. C. Götherström O. Ringdén M. Westgren C. Tammik K. Le Blanc Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells Bone Marrow Transplant 32 2003 265-272
87. K. McIntosh A. Bartholomew Stromal cell modulation of the immune system Graft 3 2000 324-328
88. S.M. Devine A.M. Bartholomew N. Mahmud et al. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion Exp Hematol 29 2001 244-255
89. A. Bartholomew S. Patil A. Mackay et al. Baboon mesenchymal stem cells can be genetically modified to secrete human erythropoietin in vivo Hum Gene Ther 12 2001 1527-1591
90. S.M. Devine C. Cobbs M. Jennings A. Bartholomew R. Hoffman Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into non-human primates Blood 101 2003 2999-3001
91. K.W. Liechty T.C. MacKenzie A.F. Shaaban et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep Nat Med 6 2000 1282-1286
92. I. Rasmusson O. Ringdén B. Sundberg K. Le Blanc Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells Transplantation 76 2003 1208-1213
93. K.-H. Grinnemo A. Mansson G. Dellgren et al. Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium J Thorac Cardiovasc Surg 127 2004 1293-1300
94. J. Potian H. Aviv N. Ponzio J. Harrison P. Rameshwar Veto-like activity of mesenchymal stem cells: Functional discrimination between cellular responses to allo-antigens and recall antigens J Immunol 171 2003 3426-3434
95. K. Le Blanc I. Rasmusson C. Götherström et al. Mesenchymal stem cells inhibit the expression of IL-2 receptor (CD25) and CD38 on phytohemagglutinin activated lymphocytes Scand J Immunol 60 2004 307-315
96. S. Aggarwal F. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815-1822
97. Rasmusson I, Ringdén O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit lymphocyte activation by mitogens and allogens by different mechanisms. Exp Cell Res. In press
98. F. Djouad P. Plence C. Bony et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals Blood 102 2003 3837-3844
99. R. Meisel A. Zibert M. Laryea U. Göbel W. Däubener D. Dilloo Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase mediated tryptophan degradation Blood 103 2004 4619-4621
100. D.H. Munn M. Zhou J.T. Attwood et al. Prevention of allogeneic fetal rejection by tryptophan catabolism Science 281 1998 1191-1193
101. H.M. Lazarus S.E. Haynesworth S.L. Gerson N.S. Rosenthal A.I. Caplan Ex vivo expansion and subsequent infusion of human bone marrow derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use Bone Marrow Transplant 16 1995 557-564
102. O.N. Koç S.L. Gerson B.W. Cooper et al. Rapid hematopoietic recovery after co-infusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy Clin Oncol 18 2000 307-316
103. J. Airey G. Almeida-Porada E. Colletti et al. Human mesenchymal stem cells form Purkinje fibers in fetal sheep heart Circulation 109 2004 1401-1407
104. E.M. Horwitz P.L. Gordon W.K. Koo et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone Proc Natl Acad Sci U S A 99 2002 8932-8937
105. L. Fouillard M. Bensidhoum D. Bories et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma Leukemia 17 2003 474-476
106. D.M. Durnam K.R. Anders L. Fisher J. O'Quigley E.M. Bryant E.D. Thomas Analysis of the origin of marrow cells in bone marrow transplant recipients using a Y-chromosome-specific in situ hybridization assay Blood 74 1989 2220-2226
107. J. Mattsson M. Uzunel M. Remberger O. Ringdén T-cell mixed chimerism is significantly correlated to a decreased risk of acute graft-versus-host disease after allogeneic stem cell transplantation Transplantation 71 2001 433-439
108. N. Stute B. Fehse J. Schroder et al. Human mesenchymal stem cells are not of donor origin in patients with severe aplastic anemia who underwent sex-mismatched allogeneic bone marrow transplant J Hematother Stem Cell Res 11 2002 977-984
109. W. Chamberlain J. Barone A. Kedo W. Fried Lack of recovery of murine hematopoietic stromal cells after irradiation-induced damage Blood 44 1974 385-392
110. W. Fried W. Chamberlain A. Kedo J. Barone Effect of radiation on hematopoietic stroma Exp Hematol 4 1976 310-314
111. E. O'Flaherty R. Sparrow J. Szer Bone marrow stromal function from patients after bone marrow transplantation Bone Marrow Transplant 15 1995 207-212
112. C. Carlostella A. Tabilio E. Regazzi et al. Effect of chemotherapy for acute myelogenous leukaemia on hematopoietic and fibroblast marrow progenitors Bone Marrow Transplant 20 1997 465-471
113. M. Galotto G. Berisso L. Delfino et al. Stromal damage as consequence of high-dose chemo/radiation therapy in bone marrow transplant recipients Exp Hematol 27 1999 1460-1466
114. N. Awaya K. Rupert E. Bryant B. Torok-Storb Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation Exp Hematol 30 2002 937-942
115. D. Cilloni C. Carlostella F. Falzetti et al. Limited engraftment capacity of bone marrow-derived mesenchymal stem cells following T-cell depleted hematopoietic stem cell transplantation Blood 96 2002 3637-3643
116. G. Almeida-Porada C. Porada N. Tran E. Zanjani Co-transplantation of human stromal cell progenitors into pre-immune fetal sheep results in an early appearance of human donor cells in circulation and boosts cell levels in bone marrow at a later timepoint after transplantation Blood 95 2000 3620-3627
117. G. Almeida-Porada A. Flake H.A. Glimp E. Zanjani Co-transplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero Exp Hematol 27 1999 1569-1575
118. P. int'Anker W. Noort A. Kruisselbrink et al. Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34+ cells in NOD/SCID mice Exp Hematol 31 2003 881-889
119. M. Angeloupoulou E. Novelli J.E. Grove et al. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice Exp Hematol 31 2003 413-420
120. O. Koç B. Mitra C. Ballas F. Brewer Engraftment and in vivo enrichment of GFP/G156A-MGMT transduced human mesenchymal stem cells in NOD-SCID mice Mol Ther 1 2000 85
121. J.R. Hobbs Bone marrow transplantation for inborn errors Lancet 2 1981 735-739
122. C.G. Groth O. Ringdén Transplantation in relation to the treatment of inherited disease Transplantation 38 1984 319-327
123. W. Krivit E.G. Shapiro L.A. Lockman et al. Bone marrow transplantation treatment for globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy and Hurler syndrome In: H.W. Moser P.J. Vinken G.W. Bruyn eds. Handbook of Clinical Neurology. Vol 66 1996 Elsevier Amsterdam 87-106
124. P.H. Byers Disorders of collagen biosynthesis and structure In: C.R. Scriver A.L. Beaudet W.S. Aly D. Valle eds. The Metabolic and Molecular Bases of Inherited Disease 3rd ed 1995 McGraw-Hill New York 4029-4077
125. O.N. Koç J. Day M. Nieder S.L. Gerson H.M. Lazarus W. Krivit Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH) Bone Marrow Transplant 30 2002 215-222
126. D.O. Sillence D.L. Rimoin D.M. Danks Clinical variability in osteogenesis imperfecta-variable expressivity of genetic heterogeneity Birth Defects Orig Artic Ser 15 1979 113-129
127. R.F. Pereira M.D. O'Hara A.V. Laptev et al. Marrow stromal cells as a source of progenitor cells for non-hematopoietic tissue in transgenic mice with a phenotype of osteogenesis imperfecta Proc Natl Acad Sci U S A 95 1998 1142-1147
128. E.M. Horwitz D.J. Prockop P.L. Gordon et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta Blood 97 2001 1227-1231
129. W. Bensinger R. Clift P. Martin et al. Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation Blood 88 1996 2794-2800
130. N. Schmitz A. Bacigalupo D. Hasenclever et al. Allogeneic bone marrow transplantation vs. filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: First results of a randomised multi-centre trial of the European Group for Blood and Marrow Transplantation Bone Marrow Transplant 21 1998 995-1003
131. G. Malm O. Ringdén J. Winiarski et al. Clinical outcome in four children with metachromatic leukodystrophy treated by bone marrow transplantation In: O. Ringdén J.R. Hobbs C.G. Steward eds. Correction of Genetic Diseases by Transplantation 1997 1997 Cogent London 28-31
132. N. Gorin M. Labopin V. Rocha et al. Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: Influence of dose and stem cell source shows better outcome with rich marrow Blood 102 2003 3043-3051
133. S.T. Lee J.H. Jang J.-W. Cheong et al. Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype Br J Haematol 118 2002 1128-1131
134. F. Frassoni M. Labopin A. Bacigalupo et al. Expanded mesenchymal stem cells (MSC), co-infused with HLA-identical hematopoietic stem cell transplants, reduce acute and chronic graft-vs-host disease: A matched pair analysis Bone Marrow Transplant 29 suppl 2 2002 S2
135. K.M. Sullivan R.P. Witherspoon R. Storb J. Nims E.D. Thomas Prednisone and azathioprine compared with prednisone and placebo for treatment of chronic graft-v-host disease: Prognostic influence of prolonged thrombocytopenia after allogeneic marrow transplantation Blood 72 1988 546-554
136. M. Uzunel J. Mattsson M. Jaksch M. Remberger O. Ringdén The significance of graft-versus-host disease and pretransplant minimal residual disease status to outcome after allogeneic stem cell transplantation in patients with acute lymphoblastic leukaemia Blood 98 2001 1982-1984
137. A. Chapel J.M. Bertho M. Bensidhoum et al. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome J Gene Med 5 2003 1028-1038
138. J. Gao J.E. Dennis R.F. Muzic M. Lundberg A.I. Caplan The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion Cells Tissues Organs 169 2001 12-20
139. L. Fouillard M. Bensidhoum D. Bories et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma Leukemia 17 2003 474-476
140. D.-W. Kim Y.-J. Chung T.-G. Kim I.-H. Oh Cotransplantation of third party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation Blood 103 2004 1941-1948
141. N.J. Chao L.-P. Koh Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens Biol Blood Marrow Transplant 10 2004 1-22
142. D. Niederwieser M. Maris J.A. Shizuru et al. Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and post-grafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with haematological diseases Blood 101 2003 1620-1629
143. P.L. Weiden K.M. Sullivan N. Fluornoy R. Storb E.D. Thomas Antileukemic effect of chronic graft-versus-host disease: Contribution to improved survival after allogeneic marrow transplantation N Engl J Med 304 1981 1529-1533
144. M.M. Horowitz R.P. Gale P.M. Sondel et al. Graft-versus-leukemia reactions following bone marrow transplantation in humans Blood 75 1989 555-562
145. O. Ringdén M. Labopin E. Gluckman et al. Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin A combined with methotrexate as prophylaxis Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation Bone Marrow Transplant 18 1996 921-929
146. M. Studeny F.C. Marini R.E. Champlin C. Zompetta I. Fidler M. Andreef Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta-delivery into tumors Cancer Res 62 2002 3603-3608
147. L. Ohlsson L. Varas C. Kjellman K. Edvardsen M. Lindvall Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix Exp Mol Pathol 75 2003 248-255
148. G.D. Wu J.A. Nolta J.-S. Yin et al. Migration of mesenchymal stem cells to heart allografts during chronic rejection Transplantation 75 2003 679-685