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Volumn 7, Issue 6, 2015, Pages 975-984

The role of piRNA and its potential clinical implications in cancer

Author keywords

cancer biomarker; cancer therapy; epigenetic network; piRNA; PIWI

Indexed keywords

BIOLOGICAL MARKER; MICRORNA; PIWI INTERACTING RNA; SMALL UNTRANSLATED RNA; UNTRANSLATED RNA; ARGONAUTE PROTEIN; PIWIL1 PROTEIN, HUMAN; SMALL INTERFERING RNA; TRANSCRIPTOME;

EID: 84939785800     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.15.37     Document Type: Review
Times cited : (80)

References (85)
  • 1
    • 79953108690 scopus 로고    scopus 로고
    • Epigenetics in cancer, what's the future?
    • 228
    • Boumber Y, Issa JP. Epigenetics in cancer, what's the future? Oncology (Williston Park) 25(3), 220-226, 228 (2011).
    • (2011) Oncology (Williston Park) , vol.25 , Issue.3 , pp. 220-226
    • Boumber, Y.1    Issa, J.P.2
  • 2
    • 79952532412 scopus 로고    scopus 로고
    • Cancer epigenetics, linking basic biology to clinical medicine
    • Tsai HC, Baylin SB. Cancer epigenetics, linking basic biology to clinical medicine. Cell Res. 21(3), 502-517 (2011).
    • (2011) Cell Res. , vol.21 , Issue.3 , pp. 502-517
    • Tsai, H.C.1    Baylin, S.B.2
  • 3
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics, two sides of the same coin?
    • You JS, Jones PA. Cancer genetics and epigenetics, two sides of the same coin? Cancer Cell 22(1), 9-20 (2012).
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 4
    • 79952201738 scopus 로고    scopus 로고
    • DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer
    • Sharma A, Heuck CJ, Fazzari MJ et al. DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer. Wiley Interdiscip. Rev. Syst. Biol. Med. 2(6), 654-669 (2010).
    • (2010) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.2 , Issue.6 , pp. 654-669
    • Sharma, A.1    Heuck, C.J.2    Fazzari, M.J.3
  • 5
    • 80054790080 scopus 로고    scopus 로고
    • DNA methylation, superior or subordinate in the epigenetic hierarchy?
    • Jin B, Li Y, Robertson KD. DNA methylation, superior or subordinate in the epigenetic hierarchy? Genes Cancer 2(6), 607-617 (2011).
    • (2011) Genes Cancer , vol.2 , Issue.6 , pp. 607-617
    • Jin, B.1    Li, Y.2    Robertson, K.D.3
  • 6
    • 79952901680 scopus 로고    scopus 로고
    • Enhancer function, new insights into the regulation of tissue-specific gene expression
    • Ong CT, Corces VG. Enhancer function, new insights into the regulation of tissue-specific gene expression. Nat. Rev. Genet. 12(4), 283-293 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , Issue.4 , pp. 283-293
    • Ong, C.T.1    Corces, V.G.2
  • 8
    • 78049414227 scopus 로고    scopus 로고
    • Epigenetic reprogramming in plant and animal development
    • Feng S, Jacobsen SE, Reik W. Epigenetic reprogramming in plant and animal development. Science 330, 622-627 (2010).
    • (2010) Science , vol.330 , pp. 622-627
    • Feng, S.1    Jacobsen, S.E.2    Reik, W.3
  • 9
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics, from mechanism to therapy
    • Dawson MA, Kouzarides T. Cancer epigenetics, from mechanism to therapy. Cell 150(1), 12-27 (2010).
    • (2010) Cell , vol.150 , Issue.1 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 11
    • 84905825772 scopus 로고    scopus 로고
    • Interplay between Epigenetics and Genetics in cancer
    • Choi JD, Lee J. Interplay between Epigenetics and Genetics in cancer. Genomics Inform. 11(4), 164-173 (2013).
    • (2013) Genomics Inform. , vol.11 , Issue.4 , pp. 164-173
    • Choi, J.D.1    Lee, J.2
  • 12
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature 447(7143), 396-398 (2007).
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 13
    • 84876859781 scopus 로고    scopus 로고
    • Dogma derailed, the many influences of RNA on the genome
    • Sabin LR, Delás MJ, Hannon GJ. Dogma derailed, the many influences of RNA on the genome. Mol. Cell 49(5), 783-794 (2013).
    • (2013) Mol. Cell , vol.49 , Issue.5 , pp. 783-794
    • Sabin, L.R.1    Delás, M.J.2    Hannon, G.J.3
  • 15
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome-biological and translational implications
    • Baylin SB, Jones PA. A decade of exploring the cancer epigenome-biological and translational implications. Nat. Rev. Cancer 11(10), 726-734 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.10 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 16
    • 78751490445 scopus 로고    scopus 로고
    • Spreading chromatin into chemical biology
    • Allis CD, Muir TW. Spreading chromatin into chemical biology. Chembiochem 12(2), 264-279 (2011).
    • (2011) Chembiochem , vol.12 , Issue.2 , pp. 264-279
    • Allis, C.D.1    Muir, T.W.2
  • 17
    • 84907500489 scopus 로고    scopus 로고
    • LncRNA, A link between RNA and cancer
    • Yang G, Lu X, Yuan L. LncRNA, A link between RNA and cancer. Biochim. Biophys. Acta 1839(11), 1097-1109 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1839 , Issue.11 , pp. 1097-1109
    • Yang, G.1    Lu, X.2    Yuan, L.3
  • 19
    • 80053897690 scopus 로고    scopus 로고
    • Role of epigenetics in cancer initiation and progression
    • Chik F, Szyf M, Rabbani SA. Role of epigenetics in cancer initiation and progression. Adv. Exp. Med. Biol. 720, 91-104 (2011).
    • (2011) Adv. Exp. Med. Biol. , vol.720 , pp. 91-104
    • Chik, F.1    Szyf, M.2    Rabbani, S.A.3
  • 21
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer, the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer, the next generation. Cell 144(5), 646-674 (2011).
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 22
    • 84856549042 scopus 로고    scopus 로고
    • Genome-scale analysis of aberrant DNA methylation in colorectal cancer
    • Hinoue T, Weisenberger DJ, Lange CP et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 22(2), 271-282 (2012).
    • (2012) Genome Res. , vol.22 , Issue.2 , pp. 271-282
    • Hinoue, T.1    Weisenberger, D.J.2    Lange, C.P.3
  • 23
    • 84877574817 scopus 로고    scopus 로고
    • The future of epigenetic therapy in solid tumours-lessons from the past
    • Azad N, Zahnow CA, Rudin CM, Baylin SB. The future of epigenetic therapy in solid tumours-lessons from the past. Nat. Rev. Clin. Oncol. 10(5), 256-266 (2013).
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , Issue.5 , pp. 256-266
    • Azad, N.1    Zahnow, C.A.2    Rudin, C.M.3    Baylin, S.B.4
  • 24
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 20, 85-93 (1980).
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 25
    • 84886744421 scopus 로고    scopus 로고
    • Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT InhibitorDecitabine
    • Turcan S, Fabius AW, Borodovsky A et al. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT InhibitorDecitabine. Oncotarget 4(10), 1729-1736 (2013).
    • (2013) Oncotarget , vol.4 , Issue.10 , pp. 1729-1736
    • Turcan, S.1    Fabius, A.W.2    Borodovsky, A.3
  • 26
    • 84886741979 scopus 로고    scopus 로고
    • 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
    • Borodovsky A, Salmasi V, Turcan S et al. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget 4(10), 1737-1747 (2013).
    • (2013) Oncotarget , vol.4 , Issue.10 , pp. 1737-1747
    • Borodovsky, A.1    Salmasi, V.2    Turcan, S.3
  • 27
    • 84910011986 scopus 로고    scopus 로고
    • Complex interactions between microRNAs and hepatitis B/C viruses
    • Fan HX, Tang H. Complex interactions between microRNAs and hepatitis B/C viruses. World J. Gastroenterol. 20(37), 13477-13492 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , Issue.37 , pp. 13477-13492
    • Fan, H.X.1    Tang, H.2
  • 28
    • 78751474118 scopus 로고    scopus 로고
    • Non-coding RNAs as regulators of embryogenesis
    • Pauli A, Rinn JL, Schier AF. Non-coding RNAs as regulators of embryogenesis. Nat. Rev. Genet. 12(2), 136-149 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , Issue.2 , pp. 136-149
    • Pauli, A.1    Rinn, J.L.2    Schier, A.F.3
  • 30
    • 84896073446 scopus 로고    scopus 로고
    • Non-coding RNAs turn up the heat, an emerging layer of novel regulators in the mammalian heat shock response
    • Place RF, Noonan EJ. Non-coding RNAs turn up the heat, an emerging layer of novel regulators in the mammalian heat shock response. Cell Stress Chaperones 19(2), 159-172 (2014).
    • (2014) Cell Stress Chaperones , vol.19 , Issue.2 , pp. 159-172
    • Place, R.F.1    Noonan, E.J.2
  • 31
    • 84946086288 scopus 로고    scopus 로고
    • An update on LNCipedia, a database for annotated human lncRNA sequences
    • Volders PJ, Verheggen K, Menschaert G et al. An update on LNCipedia, a database for annotated human lncRNA sequences. Nucleic Acids Res. 43, D174-D180 (2014).
    • (2014) Nucleic Acids Res. , vol.43 , pp. D174-D180
    • Volders, P.J.1    Verheggen, K.2    Menschaert, G.3
  • 32
    • 78149404594 scopus 로고    scopus 로고
    • MicroRNAs, a newly described class of encoded molecules that play a role in health and disease
    • Felekkis K, Touvana E, Stefanou C, Deltas C. MicroRNAs, a newly described class of encoded molecules that play a role in health and disease. Hippokratia 14(4), 236-240 (2010).
    • (2010) Hippokratia , vol.14 , Issue.4 , pp. 236-240
    • Felekkis, K.1    Touvana, E.2    Stefanou, C.3    Deltas, C.4
  • 33
    • 4444383501 scopus 로고    scopus 로고
    • Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement
    • Mochizuki K, Gorovsky MA. Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. Genes Dev. 18, 2068-2073 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2068-2073
    • Mochizuki, K.1    Gorovsky, M.A.2
  • 34
    • 27244436895 scopus 로고    scopus 로고
    • RNA-guided DNA deletion in Tetrahymena, an RNAi-based mechanism for programmed genome rearrangements
    • Yao MC, Chao JL. RNA-guided DNA deletion in Tetrahymena, an RNAi-based mechanism for programmed genome rearrangements. Annu. Rev. Genet. 39, 537-559 (2005).
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 537-559
    • Yao, M.C.1    Chao, J.L.2
  • 35
    • 34250160256 scopus 로고    scopus 로고
    • RNA maps reveal new RNA classes and a possible function for pervasive transcription
    • Kapranov P, Cheng J, Dike S et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316, 1484-1488 (2007).
    • (2007) Science , vol.316 , pp. 1484-1488
    • Kapranov, P.1    Cheng, J.2    Dike, S.3
  • 36
    • 67349157682 scopus 로고    scopus 로고
    • Tiny RNAs associated with transcription start sites in animals
    • Taft RJ, Glazov EA, Cloonan N et al. Tiny RNAs associated with transcription start sites in animals. Nat. Genet. 41, 572-578 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 572-578
    • Taft, R.J.1    Glazov, E.A.2    Cloonan, N.3
  • 37
    • 84862777814 scopus 로고    scopus 로고
    • A role for small RNAs in DNA double-strand break repair
    • Wei W, Ba Z, Gao M et al. A role for small RNAs in DNA double-strand break repair. Cell 149(1), 101-12 (2012).
    • (2012) Cell , vol.149 , Issue.1 , pp. 101-112
    • Wei, W.1    Ba, Z.2    Gao, M.3
  • 38
    • 84923063732 scopus 로고    scopus 로고
    • Regulation of microRNAs by natural agents, new strategies in cancer therapies
    • Phuah NH, Nagoor NH. Regulation of microRNAs by natural agents, new strategies in cancer therapies. Biomed. Res. Int. 2014, 804510 (2014).
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 804510
    • Phuah, N.H.1    Nagoor, N.H.2
  • 39
    • 82955172675 scopus 로고    scopus 로고
    • MicroRNAs in human diseases, from cancer to cardiovascular disease
    • Ha T. MicroRNAs in human diseases, from cancer to cardiovascular disease. Immune Netw. 11(3), 135-154 (2011).
    • (2011) Immune Netw. , vol.11 , Issue.3 , pp. 135-154
    • Ha, T.1
  • 40
    • 84901652298 scopus 로고    scopus 로고
    • MicroRNAs-A new generation molecular targets for treating cellular diseases
    • Paulmurugan R. MicroRNAs-A new generation molecular targets for treating cellular diseases. Theranostics 3(12), 927-929 (2013).
    • (2013) Theranostics , vol.3 , Issue.12 , pp. 927-929
    • Paulmurugan, R.1
  • 41
    • 84922391559 scopus 로고    scopus 로고
    • Post-transcriptional regulation of gene expression by Piwi proteins and piRNAs
    • Watanabe T, Lin H. Post-transcriptional regulation of gene expression by Piwi proteins and piRNAs. Mol. Cell 56(1), 18-27 (2014).
    • (2014) Mol. Cell , vol.56 , Issue.1 , pp. 18-27
    • Watanabe, T.1    Lin, H.2
  • 42
    • 84906877044 scopus 로고    scopus 로고
    • PiRNAs, from biogenesis to function
    • Weick EM, Miska EA. piRNAs, from biogenesis to function. Development 141(18), 3458-3471 (2014).
    • (2014) Development , vol.141 , Issue.18 , pp. 3458-3471
    • Weick, E.M.1    Miska, E.A.2
  • 43
    • 33947586544 scopus 로고    scopus 로고
    • Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing
    • Zheng X, Zhu J, Kapoor A, Zhu JK. Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. EMBO J. 26, 1691-1701 (2007).
    • (2007) EMBO J. , vol.26 , pp. 1691-1701
    • Zheng, X.1    Zhu, J.2    Kapoor, A.3    Zhu, J.K.4
  • 45
    • 84901041535 scopus 로고    scopus 로고
    • RNA-directed DNA methylation, an epigenetic pathway of increasing complexity
    • Matzke MA, Mosher RA. RNA-directed DNA methylation, an epigenetic pathway of increasing complexity. Nat. Rev. Genet. 15(6), 394-408 (2014).
    • (2014) Nat. Rev. Genet. , vol.15 , Issue.6 , pp. 394-408
    • Matzke, M.A.1    Mosher, R.A.2
  • 46
    • 77951974552 scopus 로고    scopus 로고
    • DNA methylation mediated by a microRNA pathway
    • Wu L, Zhou H, Zhang Q et al. DNA methylation mediated by a microRNA pathway. Mol. Cell 38(3), 465-475 (2010).
    • (2010) Mol. Cell , vol.38 , Issue.3 , pp. 465-475
    • Wu, L.1    Zhou, H.2    Zhang, Q.3
  • 47
    • 84892599690 scopus 로고    scopus 로고
    • PIWI proteins and PIWIinteracting RNAs in the soma
    • Ross RJ, Weiner MM, Lin H. PIWI proteins and PIWIinteracting RNAs in the soma. Nature 505(7483), 353-359 (2014).
    • (2014) Nature , vol.505 , Issue.7483 , pp. 353-359
    • Ross, R.J.1    Weiner, M.M.2    Lin, H.3
  • 48
    • 70350238350 scopus 로고    scopus 로고
    • The biogenesis and function of PIWI proteins and piRNAs: Progress and prospect
    • Thomson T, Lin H. The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu. Rev. Cell. Dev. Biol. 25, 355-376 (2009).
    • (2009) Annu. Rev. Cell. Dev. Biol. , vol.25 , pp. 355-376
    • Thomson, T.1    Lin, H.2
  • 50
    • 84880917068 scopus 로고    scopus 로고
    • PIWI-interacting RNAs: From generation to transgenerational epigenetics
    • Luteijn MJ, Ketting RF. PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat. Rev. Genet. 14(8), 523-534 (2013).
    • (2013) Nat. Rev. Genet. , vol.14 , Issue.8 , pp. 523-534
    • Luteijn, M.J.1    Ketting, R.F.2
  • 51
    • 79953089167 scopus 로고    scopus 로고
    • PIWI-interacting small RNAs: The vanguard of genome defence
    • Siomi MC, Sato K, Pezic D et al. PIWI-interacting small RNAs: The vanguard of genome defence. Nat. Rev. Mol. Cell Biol. 12(4), 246-258 (2011).
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , Issue.4 , pp. 246-258
    • Siomi, M.C.1    Sato, K.2    Pezic, D.3
  • 52
    • 84860320656 scopus 로고    scopus 로고
    • A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity
    • Rajasethupathy P, Antonov I, Sheridan R et al. A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity. Cell 149(3), 693-707 (2012).
    • (2012) Cell , vol.149 , Issue.3 , pp. 693-707
    • Rajasethupathy, P.1    Antonov, I.2    Sheridan, R.3
  • 53
    • 84859885207 scopus 로고    scopus 로고
    • Transcriptome-wide analysis of small RNA expression in early zebrafish development
    • Wei C, Salichos L, Wittgrove CM, Rokas A, Patton JG. Transcriptome-wide analysis of small RNA expression in early zebrafish development. RNA 18(5), 915-929 (2012).
    • (2012) RNA , vol.18 , Issue.5 , pp. 915-929
    • Wei, C.1    Salichos, L.2    Wittgrove, C.M.3    Rokas, A.4    Patton, J.G.5
  • 54
    • 84901952075 scopus 로고    scopus 로고
    • Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues
    • Guo Z, Maki M, Ding R et al. Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Sci. Rep. 4, 5150 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 5150
    • Guo, Z.1    Maki, M.2    Ding, R.3
  • 55
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics, DNA methylomes and histone-modification maps
    • Esteller M. Cancer epigenomics, DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8(4), 286-298 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 56
    • 81955162265 scopus 로고    scopus 로고
    • Piwis and piwi-interacting RNAs in the epigenetics of cancer
    • Siddiqi S, Matushansky IJ. Piwis and piwi-interacting RNAs in the epigenetics of cancer. Cell. Biochem. 113(2), 373-380 (2012).
    • (2012) Cell. Biochem. , vol.113 , Issue.2 , pp. 373-380
    • Siddiqi, S.1    Matushansky, I.J.2
  • 57
    • 84901027064 scopus 로고    scopus 로고
    • Mammalian epigenetic mechanisms
    • Zhang G, Pradhan S. Mammalian epigenetic mechanisms. IUBMB Life 66(4), 240-256 (2014).
    • (2014) IUBMB Life , vol.66 , Issue.4 , pp. 240-256
    • Zhang, G.1    Pradhan, S.2
  • 58
    • 84898641968 scopus 로고    scopus 로고
    • MiRNA expression profile for the human gastric antrum region using ultra-deep sequencing
    • Moreira FC, Assumpção M, Hamoy IG et al. MiRNA expression profile for the human gastric antrum region using ultra-deep sequencing. PLoS ONE 9(3), e92300 (2014).
    • (2014) PLoS ONE , vol.9 , Issue.3 , pp. e92300
    • Moreira, F.C.1    Assumpção, M.2    Hamoy, I.G.3
  • 60
    • 79959321051 scopus 로고    scopus 로고
    • PiRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells
    • Cheng J, Guo JM, Xiao BX et al. piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. Clin. Chim. Acta 412(17-18), 1621-1625 (2011).
    • (2011) Clin. Chim. Acta , vol.412 , Issue.17-18 , pp. 1621-1625
    • Cheng, J.1    Guo, J.M.2    Xiao, B.X.3
  • 61
    • 80051691142 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as marks
    • Cui L, Lou Y, Zhang X et al. Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as marks. Clin. Biochem. 44(13), 1050-1057 (2011).
    • (2011) Clin. Biochem. , vol.44 , Issue.13 , pp. 1050-1057
    • Cui, L.1    Lou, Y.2    Zhang, X.3
  • 62
    • 81955161868 scopus 로고    scopus 로고
    • PiR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells
    • Cheng J, Deng H, Xiao B et al. piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells. Cancer Lett. 315(1), 12-17 (2012).
    • (2012) Cancer Lett. , vol.315 , Issue.1 , pp. 12-17
    • Cheng, J.1    Deng, H.2    Xiao, B.3
  • 63
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; Clinical implications of multicentric origin
    • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6, 963-968 (1953).
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 64
    • 79960989834 scopus 로고    scopus 로고
    • Stem cell quiescence
    • Li L, Bhatia R. Stem cell quiescence. Clin. Cancer Res. 17(15), 4936-4941 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.15 , pp. 4936-4941
    • Li, L.1    Bhatia, R.2
  • 65
    • 84882752796 scopus 로고    scopus 로고
    • Implication of stem cells in the biology and therapy of head and neck cancer
    • Epub ahead of print
    • Wollenberg B. Implication of stem cells in the biology and therapy of head and neck cancer. GMS Curr. Top. Otorhinolaryngol. Head Neck Surg. 10, Doc01, doi:10.3205/cto000074 (2011) (Epub ahead of print).
    • (2011) GMS Curr. Top. Otorhinolaryngol. Head Neck Surg. , vol.10 , pp. Doc01
    • Wollenberg, B.1
  • 66
    • 84922704098 scopus 로고    scopus 로고
    • Epigenetics of cancer stem cells, pathways and therapeutics
    • Shukla S, Meeran SM. Epigenetics of cancer stem cells, pathways and therapeutics. Biochim. Biophys. Acta 1840(12), 3494-3502 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1840 , Issue.12 , pp. 3494-3502
    • Shukla, S.1    Meeran, S.M.2
  • 67
    • 0042124978 scopus 로고    scopus 로고
    • Identification of eight members of the Argonaute family in the human genome
    • Sasaki T, Shiohama A, Minoshima S, Shimizu N. Identification of eight members of the Argonaute family in the human genome. Genomics 82(3), 323-330 (2003).
    • (2003) Genomics , vol.82 , Issue.3 , pp. 323-330
    • Sasaki, T.1    Shiohama, A.2    Minoshima, S.3    Shimizu, N.4
  • 68
    • 84864299705 scopus 로고    scopus 로고
    • The PIWI protein acts as a predictive marker for human gastric cancer
    • Wang Y, Liu Y, Shen X et al. The PIWI protein acts as a predictive marker for human gastric cancer. Int. J. Clin. Exp. Pathol. 25(4), 315-325 (2012).
    • (2012) Int. J. Clin. Exp. Pathol. , vol.25 , Issue.4 , pp. 315-325
    • Wang, Y.1    Liu, Y.2    Shen, X.3
  • 69
    • 84916235869 scopus 로고    scopus 로고
    • Hiwi downregulation, mediated by shRNA, reduces the proliferation and migration of human hepatocellular carcinoma cells
    • Xie Y, Yang Y, Ji D, Zhang D, Yao X, Zhang X. Hiwi downregulation, mediated by shRNA, reduces the proliferation and migration of human hepatocellular carcinoma cells. Mol. Med. Rep. 11(2), 1455-1461 (2015).
    • (2015) Mol. Med. Rep. , vol.11 , Issue.2 , pp. 1455-1461
    • Xie, Y.1    Yang, Y.2    Ji, D.3    Zhang, D.4    Yao, X.5    Zhang, X.6
  • 70
    • 33645226840 scopus 로고    scopus 로고
    • Expression of Hiwi gene in human gastric cancer was associated with proliferation of cancer cells
    • Liu X, Sun Y, Guo J et al. Expression of Hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int. J. Cancer 118, 1922-1929 (2006).
    • (2006) Int. J. Cancer , vol.118 , pp. 1922-1929
    • Liu, X.1    Sun, Y.2    Guo, J.3
  • 71
    • 84908004430 scopus 로고    scopus 로고
    • PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation
    • Yao Y, Li C, Zhou X et al. PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation. Oncotarget 5(18), 8466-8477 (2014).
    • (2014) Oncotarget , vol.5 , Issue.18 , pp. 8466-8477
    • Yao, Y.1    Li, C.2    Zhou, X.3
  • 72
    • 33847044299 scopus 로고    scopus 로고
    • Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma
    • Taubert H, Greither T, Kaushal D et al. Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. Oncogene 26, 1098-1100 (2007).
    • (2007) Oncogene , vol.26 , pp. 1098-1100
    • Taubert, H.1    Greither, T.2    Kaushal, D.3
  • 74
    • 84884400805 scopus 로고    scopus 로고
    • MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer
    • Calcagno DQ, Freitas VM, Leal MF et al. MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer. BMC Gastroenterol. 13, 141 (2013).
    • (2013) BMC Gastroenterol. , vol.13 , pp. 141
    • Calcagno, D.Q.1    Freitas, V.M.2    Leal, M.F.3
  • 75
    • 84878070584 scopus 로고    scopus 로고
    • MYC deregulation in gastric cancer and its clinicopathological implications
    • de Souza CR, Leal MF, Calcagno DQ et al. MYC deregulation in gastric cancer and its clinicopathological implications. PLoS ONE 8(5), e64420 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.5 , pp. e64420
    • De Souza, C.R.1    Leal, M.F.2    Calcagno, D.Q.3
  • 76
    • 0037030522 scopus 로고    scopus 로고
    • Molecular characterization of Hiwi, a human member of the PIWI gene family whose overexpression is correlated to seminomas
    • Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. Molecular characterization of Hiwi, a human member of the PIWI gene family whose overexpression is correlated to seminomas. Oncogene 21, 3988-3999 (2002).
    • (2002) Oncogene , vol.21 , pp. 3988-3999
    • Qiao, D.1    Zeeman, A.M.2    Deng, W.3    Looijenga, L.H.4    Lin, H.5
  • 77
    • 31144460828 scopus 로고    scopus 로고
    • Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway
    • Lee JH, Schütte D, Wulf G et al. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Hum. Mol. Genet. 15, 201-211 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 201-211
    • Lee, J.H.1    Schütte, D.2    Wulf, G.3
  • 78
    • 84860666743 scopus 로고    scopus 로고
    • HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection
    • Zhao YM, Zhou JM, Wang LR et al. HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection. Cancer 118, 2708-2717 (2012).
    • (2012) Cancer , vol.118 , pp. 2708-2717
    • Zhao, Y.M.1    Zhou, J.M.2    Wang, L.R.3
  • 80
    • 79959321051 scopus 로고    scopus 로고
    • PiRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells
    • Cheng J, Guo JM, Xiao BX et al. piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. Clin. Chim. Acta 412(17-18), 1621-1615 (2011).
    • (2011) Clin. Chim. Acta , vol.412 , Issue.17-18 , pp. 1621-1625
    • Cheng, J.1    Guo, J.M.2    Xiao, B.X.3
  • 81
    • 84879798482 scopus 로고    scopus 로고
    • Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer
    • Huang G, Hu H, Xue X et al. Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer. Clin. Transl. Oncol. 15(7), 563-568 (2013).
    • (2013) Clin. Transl. Oncol. , vol.15 , Issue.7 , pp. 563-568
    • Huang, G.1    Hu, H.2    Xue, X.3
  • 82
    • 84908170488 scopus 로고    scopus 로고
    • Tracking down the origin of cancer, metabolic reprogramming as a driver of stemness and tumorigenesis
    • Sebastian C. Tracking down the origin of cancer, metabolic reprogramming as a driver of stemness and tumorigenesis. Crit. Rev. Oncog. 19(5), 363-382 (2014).
    • (2014) Crit. Rev. Oncog. , vol.19 , Issue.5 , pp. 363-382
    • Sebastian, C.1
  • 83
    • 84899719487 scopus 로고    scopus 로고
    • Cancer stem cells converted from pluripotent stem cells and the cancerous niche
    • Kasai T, Chen L, Mizutani A et al. Cancer stem cells converted from pluripotent stem cells and the cancerous niche. J. Stem Cells Regen. Med. 10(1), 2-7 (2014).
    • (2014) J. Stem Cells Regen. Med. , vol.10 , Issue.1 , pp. 2-7
    • Kasai, T.1    Chen, L.2    Mizutani, A.3
  • 85
    • 84937434900 scopus 로고    scopus 로고
    • Highthroughput miRNA sequencing reveals a field effect in gastric cancer and suggests an epigenetic network mechanism
    • In Press
    • Assumpção MB, Moreira FC, Hamoy IG et al. Highthroughput miRNA sequencing reveals a field effect in gastric cancer and suggests an epigenetic network mechanism. Bioinform. Biol. Insights (2015) (In Press).
    • (2015) Bioinform. Biol. Insights
    • Assumpção, M.B.1    Moreira, F.C.2    Hamoy, I.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.