Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

Nature Communications

Volumn 6, Issue , 2015, Pages

  Ruiz, Sergio ^a   Lopez Contreras, Andres J ^a,g   Gabut, Mathieu ^b,c,h   Marion, Rosa M ^a   Gutierrez Martinez, Paula ^a   Bua, Sabela ^d   Ramirez, Oscar ^e   Olalde, Iñigo ^e   Rodrigo Perez, Sara ^a   Li, Han ^d   Marques Bonet, Tomas ^e,f   Serrano, Manuel ^a   Blasco, Maria A ^a   Batada, Nizar N ^b,c   Fernandez Capetillo, Oscar ^a  

^a Structural Biology and Biocomputing Programme   (Spain)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d INSTITUT PASTEUR   (France)

^e UNIVERSITAT POMPEU FABRA   (Spain)

^f Centro Nacional de Analisis Genomico CNAG   (Spain)

^g UNIVERSITY OF COPENHAGEN   (Denmark)

^h UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; NUCLEOSIDE; CHEK1 PROTEIN, HUMAN; CHEK1 PROTEIN, MOUSE; DNA; PROTEIN KINASE;

ADULT; CELLS AND CELL COMPONENTS; DNA; ENZYME ACTIVITY; GENOMICS; HOMINID; INJURY; RODENT;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL STRESS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; EMBRYO; GENE REARRANGEMENT; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; SOMATIC CELL; ANIMAL; CELL LINE; CELL PROLIFERATION; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; NUCLEIC ACID HYBRIDIZATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PLASMID; POINT MUTATION; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELLULAR REPROGRAMMING; CHECKPOINT KINASE 1; DNA; FIBROBLASTS; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, TRANSGENIC; NUCLEIC ACID HYBRIDIZATION; PLASMIDS; POINT MUTATION; PROTEIN KINASES; STRESS, PHYSIOLOGICAL;

EID: 84939780353     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9036     Document Type: Article

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