Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation

European Journal of Nutrition

Volumn 55, Issue 5, 2016, Pages 1863-1873

  Pusceddu, Irene ^a   Herrmann, Markus ^b   Kirsch, Susanne H ^a   Werner, Christian ^a   Hübner, Ulrich ^a   Bodis, Marion ^a   Laufs, Ulrich ^a   Wagenpfeil, Stefan ^a   Geisel, Jürgen ^a   Herrmann, Wolfgang ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Bolzano County Hospital   (Italy)

Author keywords

B vitamins; DNA methylation; Telomere length

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CALCIUM; CYANOCOBALAMIN; CYSTATHIONINE; FOLIC ACID; GENOMIC DNA; HOMOCYSTEINE; PYRIDOXINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; VITAMIN B GROUP; VITAMIN D; 5-METHYLTETRAHYDROFOLATE; TETRAHYDROFOLIC ACID DERIVATIVE; VITAMIN B COMPLEX;

AGED; ARTICLE; BLOOD; BLOOD CELL; BLOOD SAMPLING; CONTROLLED STUDY; DIET RESTRICTION; DNA EXTRACTION; DNA METHYLATION; FEMALE; GERIATRIC PATIENT; HUMAN; HYPERHOMOCYSTEINEMIA; LINE 1 METHYLATION; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PROSPECTIVE STUDY; REGRESSION ANALYSIS; TELOMERE HOMEOSTASIS; VITAMIN SUPPLEMENTATION; CROSS-SECTIONAL STUDY; DIETARY SUPPLEMENT; DRUG EFFECTS; GENETICS; LONG INTERSPERSED REPEAT; MIDDLE AGED; STATISTICAL MODEL; TELOMERE; ULTRASTRUCTURE;

AGED; BLOOD CELLS; CALCIUM; CROSS-SECTIONAL STUDIES; DIETARY SUPPLEMENTS; DNA METHYLATION; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LINEAR MODELS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; TELOMERE; TETRAHYDROFOLATES; VITAMIN B 12; VITAMIN B 6; VITAMIN B COMPLEX; VITAMIN D;

EID: 84939630063     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-1003-1     Document Type: Article

References (41)

1. 12 deficiency. N Engl J Med 368:149–160
2. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281
3. Herrmann W, Schorr H, Bodis M, Knapp JP, Muller A, Stein G, Geisel J (2000) Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects. Eur J Clin Invest 30:1083–1089
4. 12 and ageing: current issues and interaction with folate. Ann Clin Biochem 50:315–329
5. Moores CJ, Fenech M, O’Callaghan NJ (2014) Telomere dynamics: the influence of folate and DNA methylation. Ann N Y Acad Sci 1229:76–88
6. Wainfan E, Poirier LA (1992) Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res 52:2071s–2077s
7. Nazki FHSAGB (2014) Folate: metabolism, genes, polymorphisms and the associated diseases. Gene 533:11–20
8. Kazazian HH (2014) Mobile elements: drivers of genome evolution. Science 303:1626–1632
9. Blasco MA (2007) Telomere length, stem cells and aging. Nat Chem Biol 3:640–649
10. Blasco MA (2005) Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6:611–622
11. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614–636
12. Fyhrquist F, Saijonmaa O, Strandberg T (2013) The roles of senescence and telomere shortening in cardiovascular disease. Nat Rev Cardiol 10:274–283
13. Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361:393–395
14. Armanios M (2013) Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest 123:996–1002
15. Svenson U, Nordfjall K, Stegmayr B, Manjer J, Nilsson P, Tavelin B, Henriksson R, Lenner P, Roos G (2008) Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res 68:3618–3623
16. Li H, Engström K, Vahter M, Broberg K (2014) Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood. Chem Res Toxicol 25:2333–2339
17. Richards JB, Valdes AM, Gardner JP, Kato BS, Siva A, Kimura M, Lu X, Brown MJ, Aviv A, Spector TD (2008) Homocysteine levels and leukocyte telomere length. Atherosclerosis 200:271–277
18. Paul L, Cattaneo M, D’Angelo A, Sampietro F, Fermo I, Razzari C, Fontana G, Eugene N, Jacques PF, Selhub J (2009) Telomere length in peripheral blood mononuclear cells is associated with folate status in men. J Nutr 139:1273–1278
19. Liu JJ, Prescott J, Giovannucci E, Hankinson SE, Rosner B, De Vivo I (2013) One-carbon metabolism factors and leukocyte telomere length. Am J Clin Nutr 97:794–799
20. Paul L, Jacques PF, Aviv A, Vasan RS, D’Agostino RB, Levy D, Selhub J (2014) High plasma folate is negatively associated with leukocyte telomere length in the Framingham Offspring cohort. Eur J Nutr 54:235–241
21. Herrmann W, Kirsch SH, Kruse V, Eckert R, Graber S, Geisel J, Obeid R (2013) One year B and D vitamins supplementation improves metabolic bone markers. Clin Chem Lab Med 51:639–647
22. Hubner U, Geisel J, Kirsch SH, Kruse V, Bodis M, Klein C, Herrmann W, Obeid R (2013) Effect of 1 year B and D vitamin supplementation on LINE-1 repetitive element methylation in older subjects. Clin Chem Lab Med 51:649–655
23. Geisel J, Schorr H, Heine GH, Bodis M, Hubner U, Knapp JP, Herrmann W (2007) Decreased p66Shc promoter methylation in patients with end-stage renal disease. Clin Chem Lab Med 45:1764–1770
24. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30:2–6
25. Werner C, Fürster T, Widmann T, Pöss J, Roggia C, Hanhoun M, Scharhag J, Büchner N, Meyer T, Kindermann W, Haendeler J, Böhm M, Laufs U (2009) Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation 120:2438–2447
26. Kirsch SH, Herrmann W, Kruse V, Eckert R, Gräber S, Geisel J, Obeid R (2014) One year B-vitamins increases serum and whole blood forms and lowers plasma homocysteine in older Germans. Clin Chem Lab Med 53:445–452
27. Kirsch SH, Knapp JP, Herrmann W, Obeid R (2010) Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 878:68–75
28. Stabler SP, Marcell PD, Podell ER, Allen RH (1987) Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 162:185–196
29. Kirsch SH, Knapp JP, Geisel J, Herrmann W, Obeid R (2009) Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877:3865–3870
30. Müezzinler A, Zaineddin AK, Brenner H (2013) A systematic review of leukocyte telomere length and age in adults. Ageing Res Rev 12:509–519
31. Weischer M, Bojesen SE, Nordestgaard BG (2014) Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4576 general population individuals with repeat measurements 10 years apart. PLoS Genet 10:1–11
32. Ehrlenbach S, Willeit P, Kiechl S, Willeit J, Reindl M, Schanda K, Kronenberg F, Brandstatter A (2009) Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck study: introduction of a well-controlled high-throughput assay. Int J Epidemiol 38:1725–1734
33. Epel ES, Merkin SS, Cawthon RM, Blackburn EH, Adler NE, Pletcher MJ, Seeman TE (2008) The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging 4:88
34. Nordfjall K, Svenson U, Norrback KF, Adolfsson R, Lenner P, Roos G (2009) The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet 5:e1000375
35. Aviv A, Chen W, Gardner JP, Kimura M, Brimacombe M, Cao X, Srinivasan SR, Berenson GS (2009) Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol 169:323–329
36. Svenson U, Nordfjall K, Baird D, Roger L, Osterman P, Hellenius ML, Roos G (2011) Blood cell telomere length is a dynamic feature. PLoS One 6:e21485
37. Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, Blasco MA (2006) DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 8:416–424
38. Bull CF, Mayrhofer G, O’Callaghan NJ, Au AY, Pickett HA, Low GKM, Zeegers D, Hande MP, Fenech MF (2013) Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells. Cancer Prev Res (Phila) 7:128–138
39. Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DC (2014) The association between global DNA methylation and telomere length in a longitudinal study of boilermarkers. Genet Epidemiol 38:254–265
40. Li H, Hilmarsen HT, Hossain MB, Björk J, Hansteen IL, Albin M, Furu Skjelbred C, Broberg K (2013) Telomere length and LINE-1 methylation is associated with chromosomal aberrations in peripheral blood. Genes Chromosomes Cancer 52:1–10
41. Morrish TA, Garcia-Perez JL, Stamato TD, Taccioli GE, Sekiguchi J, Moran JV (2007) Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres. Nature 446:208–212