Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General Population Individuals with Repeat Measurements 10 Years Apart

PLoS Genetics

Volumn 10, Issue 3, 2014, Pages

  Weischer, Maren ^a,b   Bojesen, Stig E ^a,b,c   Nordestgaard, Børge G ^a,b,c  

^a Mental Health Center Glostrup   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c FREDERIKSBERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BASE PAIRING; BODY MASS; BODY WEIGHT; CEREBROVASCULAR DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; FEMALE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OBSERVATIONAL STUDY; PHYSICAL ACTIVITY; PHYSICAL INACTIVITY; POLYMERASE CHAIN REACTION; POPULATION; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; SMOKING; TELOMERE SHORTENING; CYTOLOGY; DRINKING BEHAVIOR; GENETICS; LEUKOCYTE; MIDDLE AGED; MOTOR ACTIVITY; POPULATION GENETICS; RISK FACTOR; TELOMERE;

ADULT; ALCOHOL DRINKING; BODY MASS INDEX; BODY WEIGHT; FEMALE; GENETICS, POPULATION; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MOTOR ACTIVITY; RISK FACTORS; SMOKING; TELOMERE; TELOMERE SHORTENING;

EID: 84897397399     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004191     Document Type: Article

References (40)

1. Blackburn EH, (1991) Structure and function of telomeres. Nature 350: 569-573 10.1038/350569a0 [doi].
2. Weischer M, Bojesen SE, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, et al. (2012) Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death. Arterioscler Thromb Vasc Biol 32: 822-829.
3. Wong JM, Collins K, (2003) Telomere maintenance and disease. Lancet 362: 983-988 S0140-6736(03)14369-3 [pii];10.1016/S0140-6736(03)14369-3 [doi].
4. Fitzpatrick AL, Kronmal RA, Kimura M, Gardner JP, Psaty BM, et al. (2011) Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci 66: 421-429 glq224 [pii];10.1093/gerona/glq224 [doi].
5. Willeit P, Willeit J, Kloss-Brandstatter A, Kronenberg F, Kiechl S, (2011) Fifteen-year follow-up of association between telomere length and incident cancer and cancer mortality. JAMA 306: 42-44 306/1/42-a [pii];10.1001/jama.2011.901 [doi].
6. Willeit P, Willeit J, Brandstatter A, Ehrlenbach S, Mayr A, et al. (2010) Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk. Arterioscler Thromb Vasc Biol pp. 1649-1655.
7. Ma H, Zhou Z, Wei S, Liu Z, Pooley KA, et al. (2011) Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One 6: e20466 10.1371/journal.pone.0020466 [doi];PONE-D-11-04747 [pii].
8. Wentzensen IM, Mirabello L, Pfeiffer RM, Savage SA, (2011) The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 20: 1238-1250 1055-9965.EPI-11-0005 [pii];10.1158/1055-9965.EPI-11-0005 [doi].
9. Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, et al. (2013) Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 105: 459-468 djt016 [pii];10.1093/jnci/djt016 [doi].
10. Butt HZ, Atturu G, London NJ, Sayers RD, Bown MJ, (2010) Telomere length dynamics in vascular disease: a review. Eur J Vasc Endovasc Surg 40: 17-26.
11. Cherkas LF, Hunkin JL, Kato BS, Richards JB, Gardner JP, et al. (2008) The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med 168: 154-158.
12. von Zglinicki T, Martin-Ruiz CM, (2005) Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med 5: 197-203.
13. Londono-Vallejo JA, (2008) Telomere instability and cancer. Biochimie 90: 73-82.
14. Mather KA, Jorm AF, Parslow RA, Christensen H, (2011) Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci 66: 202-213.
15. Clarke R, Shipley M, Lewington S, Youngman L, Collins R, et al. (1999) Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. Am J Epidemiol 150: 341-353.
16. Aviv A, Chen W, Gardner JP, Kimura M, Brimacombe M, et al. (2009) Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol 169: 323-329 kwn338 [pii];10.1093/aje/kwn338 [doi].
17. Ehrlenbach S, Willeit P, Kiechl S, Willeit J, Reindl M, et al. (2009) Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. Int J Epidemiol 38: 1725-1734.
18. Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, et al. (2009) The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) 1: 81-88.
19. Nordfjall K, Svenson U, Norrback KF, Adolfsson R, Lenner P, et al. (2009) The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet 5: e1000375 10.1371/journal.pgen.1000375 [doi].
20. Ujvari B, Madsen T, (2009) Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons. PLoS One 4: e7493 10.1371/journal.pone.0007493 [doi].
21. Broccoli D, Young JW, de LT, (1995) Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci U S A 92: 9082-9086.
22. Hathcock KS, Jeffrey CY, Hodes RJ, (2005) In vivo regulation of telomerase activity and telomere length. Immunol Rev 205: 104-113 IMR267 [pii];10.1111/j.0105-2896.2005.00267.x [doi].
23. Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, et al. (2010) Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods 352: 71-80 S0022-1759(09)00292-0 [pii];10.1016/j.jim.2009.09.012 [doi].
24. Trentin L, Ballon G, Ometto L, Perin A, Basso U, et al. (1999) Telomerase activity in chronic lymphoproliferative disorders of B-cell lineage. Br J Haematol 106: 662-668 bjh1620 [pii].
25. Weng NP, Granger L, Hodes RJ, (1997) Telomere lengthening and telomerase activation during human B cell differentiation. Proc Natl Acad Sci U S A 94: 10827-10832.
26. Steenstrup T, Hjelmborg JV, Kark JD, Christensen K, Aviv A, (2013) The telomere lengthening conundrum-artifact or biology? Nucleic Acids Res 41: e131 gkt370 [pii];10.1093/nar/gkt370 [doi].
27. Rothman KJ, Greenland S, and Lash TL (2008) Modern Epidemiology. Lippencott-Raven Publishers; 2008:183-209. Lippencott-Raven Publishers. 186 p.
28. Rode L, Bojesen SE, Weischer M, Vestbo J, Nordestgaard BG, (2013) Short telomere length, lung function and chronic obstructive pulmonary disease in 46,396 individuals. Thorax 68: 429-435 thoraxjnl-2012-202544 [pii];10.1136/thoraxjnl-2012-202544 [doi].
29. Savale L, Chaouat A, Bastuji-Garin S, Marcos E, Boyer L, et al. (2009) Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 179: 566-571 200809-1398OC [pii];10.1164/rccm.200809-1398OC [doi].
30. Ding H, Chen C, Shaffer JR, Liu L, Xu Y, et al. (2012) Telomere length and risk of stroke in Chinese. Stroke 43: 658-663 STROKEAHA.111.637207 [pii];10.1161/STROKEAHA.111.637207 [doi].
31. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, et al. (2007) Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 165: 14-21.
32. Friedrich U, Griese E, Schwab M, Fritz P, Thon K, et al. (2000) Telomere length in different tissues of elderly patients. Mech Ageing Dev 119: 89-99.
33. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, et al. (2002) Telomere length in the newborn. Pediatr Res 52: 377-381.
34. Wilson WR, Herbert KE, Mistry Y, Stevens SE, Patel HR, et al. (2008) Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. Eur Heart J 29: 2689-2694.
35. Storm HH, (1988) Completeness of cancer registration in Denmark 1943-1966 and efficacy of record linkage procedures. Int J Epidemiol 17: 44-49.
36. Storm HH, Michelsen EV, Clemmensen IH, Pihl J, (1997) The Danish Cancer Registry-history, content, quality and use. Dan Med Bull 44: 535-539.
37. Cawthon RM, (2009) Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 37: e21.
38. Cawthon RM, (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30: e47.
39. Akiyama M, Yamada O, Kanda N, Akita S, Kawano T, et al. (2002) Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors. Cancer Lett 178: 187-197 S0304383501008382 [pii].
40. Wang Y, Fang MY, (2006) Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line. Zhongguo Shi Yan Xue Ye Xue Za Zhi 14: 1089-1095 1009-2137(2006)06-1089-07 [pii].