Effect of 1 year B and D vitamin supplementation on LINE-1 repetitive element methylation in older subjects

Clinical Chemistry and Laboratory Medicine

Volumn 51, Issue 3, 2013, Pages 649-655

  Hubner, Ulrich ^a   Geisel, Jürgen ^a   Kirsch, Susanne H ^a   Kruse, Vera ^a   Bodis, Marion ^a   Klein, Cosima ^a   Herrmann, Wolfgang ^a   Obeid, Rima ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

B vitamins; Homocysteine; Long interspersed nuclear element 1; Methylation; S adenosylhomocysteine; S adenosylmethionine

Indexed keywords

CALCIUM; CREATININE; CYANOCOBALAMIN; FOLIC ACID; GENOMIC DNA; HOMOCYSTEINE; PYRIDOXINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; VITAMIN D;

AGED; BLOOD SAMPLING; CLINICAL ARTICLE; CONFERENCE PAPER; DIET RESTRICTION; DNA METHYLATION; DRUG EFFECT; FEMALE; HUMAN; LONG INTERSPERSED NUCLEAR ELEMENT 1; LONG INTERSPERSED REPEAT; LONG TERM CARE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROPOSON; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

AGED; AGED, 80 AND OVER; CALCIUM CARBONATE; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DNA METHYLATION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HOMOCYSTEINE; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; MIDDLE AGED; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; VITAMIN B COMPLEX;

EID: 84882654145     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0624     Document Type: Conference Paper

References (36)

1. Kitkumthorn N, Mutirangura A. Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications. Clin Epigenet 2011;2:315-30.
2. Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 2007;447:433-40.
3. Balaghi M, Wagner C. DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun 1993;193:1184-90.
4. Duthie SJ, Narayanan S, Brand GM, Pirie L, Grant G. Impact of folate deficiency on DNA stability. J Nutr 2002;132:2444-S9S.
5. Kazazian HH Jr. Mobile elements: drivers of genome evolution. Science 2004;303:1626-32.
6. Yang AS, Estécio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004;32:e38.
7. Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, et al. Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr 2007;137:1713-7.
8. Liu Z, Choi SW, Crott JW, Keyes MK, Jang H, Smith DE, et al. Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. J Nutr 2007;137:2701-8.
9. Pogribny IP, Ross SA, Wise C, Pogribna M, Jones EA, Tryndyak VP, et al. Irreversible global DNA methylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res 2006;593:80-7.
10. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, et al. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 1998;128:1204-12.
11. Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 2000;72:998-1003.
12. Pizzolo F, Blom HJ, Choi SW, Girelli D, Guarini P, Martinelli N, et al. Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia. J Am Coll Nutr 2011;30:11-8.
13. Karlic H, Varga F. Impact of vitamin D metabolism on clinical epigenetics. Clin Epigenet 2011;2:55-61.
14. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 2010;20:1352-60.
15. Jung AY, Smulders Y, Verhoef P, Kok FJ, Blom H, Kok RM, et al. No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine. PloS One 2011;6:e24976.
16. Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH, Powers HJ. Sensitivity of markers of DNA stanility and DNA repair activity to folate supplementation in healthy volunteers. Br J Cancer 2006;94:1942-7.
17. Kirsch SH, Knapp JP, Geisel J, Herrmann W, Obeid R. Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:3865-70.
18. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency. Metabolism 1993;42:978-88.
19. Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988;81:466-74.
20. Stabler SP, Lindenbaum J, Savage DG, Allen RH. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 1993;81:3404-13.
21. Issa JP, Gharibyran V, Cortes J, Jelinik J, Morris G, Verstovsek S, et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukaemia resistant to imatinib mesylate. J Clin Oncol 2005;23:3948-56.
22. Geisel J, Schorr H, Heine GH, Bodis M, Hübner U, Knapp JP, et al. Decreased p66Shc promotor methylation in patients with end-stage renal disease. Clin Chem Lab Med 2007;45:1764-70.
23. Verri A, Focher F, Tettamanti G, Grazioli V. Two-step genetic screening of thrombophilia by pyrosequencing. Clin Chem 2005;51:1282-4.
24. Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S, et al. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut 2005;54:648-53.
25. Stefanska B, Rudnicka K, Bednarek A, Fabianowska-Majewska K. Hypomethylation and induction of retinoic receptor beta 2 by concurrent action of adenosine analogues and natural compunds in breast cancer cells. Eur J Pharmacol 2010;638:47-53.
26. Stefanska B, Salamé P, Bednarek A, Fabianowska-Majewska K. Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr 2012;107:781-90.
27. 3-induced DNA methylation suppresses the human CYP27B1 gene. Mol Cell Endocrinol 2007;265-6:168-73.
28. Haslberger A, Varga F, Karlic H. Recursive causality in evolution: a model for epigenetic mechanisms in cancer development. Med Hypotheses 2006;67:1448-54.
29. Castro R, Rivera I, Ravasco P, Camilo ME, Jakobs C, Blom HJ, et al. 5, 10-methylenetetrahydrofolate reductase (MTHFR) 677C and 1298AC mutations are associated with DNA hypomethylation. J Med Genet 2004;41:454-8.
30. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, et al. A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002;99:5606-11.
31. Green TJ, Skeaff CM, McMahon JA, Venn BJ, Williams SM, Devlin AM, et al. Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations. Clin Chem Lab Med 2010;103:1629-34.
32. Becker A, Smulders YM, Teerlink T, Struys EA, De Meer K, Kostense PJ, et al. S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations. Eur J Clin Invest 2003;33:17-25.
33. Stabler SP, Allen RH, Dolce ET, Johnson MA. Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment. Am J Clin Nutr 2006;84:1422-9.
34. Choumenkovitch SF, Selhub J, Bagley PJ, Maeda NM, Nadeau MR, Smith DE, et al. In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific. J Nutr 2002;132:2157-60.
35. Caudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan SJ, Collins MD, et al. Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr 2001;131:2811-8.
36. Baric I, Fumić K, Glenn B, Cuk M, Schulze A, Finkelstein JD, et al. S-adenosylhomo-cysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc Natl Acad Sci USA 2004;101:4234-9.