메뉴 건너뛰기




Volumn 56, Issue 8, 2015, Pages 1463-1471

P450s and UGTs: Key Players in the Structural Diversity of Triterpenoid Saponins

Author keywords

Biosynthesis; Cytochrome P450 monooxygenase; Oxidosqualene cyclase; Plant specialized metabolites; Triterpenoid saponin; UDP dependent glycosyltransferase

Indexed keywords

SOLANUM TUBEROSUM;

EID: 84939528950     PISSN: 00320781     EISSN: 14719053     Source Type: Journal    
DOI: 10.1093/pcp/pcv062     Document Type: Article
Times cited : (202)

References (57)
  • 1
    • 15544364507 scopus 로고    scopus 로고
    • Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula
    • Achnine, L., Huhman, D.V., Farag, M.A., Sumner, L.W., Blount, J.W. and Dixon, R.A. (2005) Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula. Plant J. 41: 875-887.
    • (2005) Plant J , vol.41 , pp. 875-887
    • Achnine, L.1    Huhman, D.V.2    Farag, M.A.3    Sumner, L.W.4    Blount, J.W.5    Dixon, R.A.6
  • 2
    • 51649100529 scopus 로고    scopus 로고
    • Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics
    • Anzai, Y., Li, S., Chaulagain, M.R., Kinoshita, K., Kato, F., Montgomery, J., et al. (2008) Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. Chem. Biol. 15: 950-959.
    • (2008) Chem. Biol , vol.15 , pp. 950-959
    • Anzai, Y.1    Li, S.2    Chaulagain, M.R.3    Kinoshita, K.4    Kato, F.5    Montgomery, J.6
  • 3
    • 79952231420 scopus 로고    scopus 로고
    • Genus Bupleurum: A review of its phytochemistry, pharmacology and modes of action
    • Ashour, M.L. and Wink, M. (2011) Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action. J. Pharm. Pharmacol. 63: 305-321.
    • (2011) J. Pharm. Pharmacol , vol.63 , pp. 305-321
    • Ashour, M.L.1    Wink, M.2
  • 4
    • 84870792724 scopus 로고    scopus 로고
    • UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponinmediated insect resistance
    • Augustin, J.M., Drok, S., Shinoda, T., Sanmiya, K., Nielsen, J.K., Khakimov, B., et al. (2012) UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponinmediated insect resistance. Plant Physiol. 160: 1881-1895.
    • (2012) Plant Physiol , vol.160 , pp. 1881-1895
    • Augustin, J.M.1    Drok, S.2    Shinoda, T.3    Sanmiya, K.4    Nielsen, J.K.5    Khakimov, B.6
  • 5
    • 79952900480 scopus 로고    scopus 로고
    • Molecular activities, biosynthesis and evolution of triterpenoid saponins
    • Augustin, J.M., Kuzina, V., Andersen, S.B. and Bak, S. (2011) Molecular activities, biosynthesis and evolution of triterpenoid saponins. Phytochemistry 72: 435-457.
    • (2011) Phytochemistry , vol.72 , pp. 435-457
    • Augustin, J.M.1    Kuzina, V.2    Andersen, S.B.3    Bak, S.4
  • 9
    • 84905538254 scopus 로고    scopus 로고
    • Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins
    • Carelli, M., Biazzi, E., Panara, F., Tava, A., Scaramelli, L., Porceddu, A., et al. (2011) Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins. Plant Cell 23: 3070-3081.
    • (2011) Plant Cell , vol.23 , pp. 3070-3081
    • Carelli, M.1    Biazzi, E.2    Panara, F.3    Tava, A.4    Scaramelli, L.5    Porceddu, A.6
  • 10
    • 84876471789 scopus 로고    scopus 로고
    • An effective strategy for exploring unknown metabolic pathways by genome mining
    • Castillo D.A., Kolesnikova, M.D. and Matsuda, S.P.T. (2013) An effective strategy for exploring unknown metabolic pathways by genome mining. J. Amer. Chem. Soc. 135, 5885-5894.
    • (2013) J. Amer. Chem. Soc , vol.135 , pp. 5885-5894
    • Castillo, D.A.1    Kolesnikova, M.D.2    Matsuda, S.P.T.3
  • 11
    • 0038047657 scopus 로고    scopus 로고
    • Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
    • Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H. and Doerr, H.W. (2003) Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361: 2045-2046.
    • (2003) Lancet , vol.361 , pp. 2045-2046
    • Cinatl, J.1    Morgenstern, B.2    Bauer, G.3    Chandra, P.4    Rabenau, H.5    Doerr, H.W.6
  • 12
    • 78649443323 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in the fungal kingdom
    • Cresnar, B. and Petric, S. (2011) Cytochrome P450 enzymes in the fungal kingdom. Biochim. Biophys. Acta 1814: 29-35.
    • (2011) Biochim. Biophys. Acta , vol.1814 , pp. 29-35
    • Cresnar, B.1    Petric, S.2
  • 14
    • 42549088178 scopus 로고    scopus 로고
    • Metabolic diversification-independent assembly of operon-like gene clusters in different plants
    • Field, B. and Osbourn, A.E. (2008) Metabolic diversification-independent assembly of operon-like gene clusters in different plants. Science 320: 543-547.
    • (2008) Science , vol.320 , pp. 543-547
    • Field, B.1    Osbourn, A.E.2
  • 15
    • 83255176933 scopus 로고    scopus 로고
    • CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis
    • Fukushima, E.O., Seki, H., Ohyama, K., Ono, E., Umemoto, N., Mizutani, M., et al. (2011) CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant Cell Physiol. 52: 2050-2061.
    • (2011) Plant Cell Physiol , vol.52 , pp. 2050-2061
    • Fukushima, E.O.1    Seki, H.2    Ohyama, K.3    Ono, E.4    Umemoto, N.5    Mizutani, M.6
  • 16
    • 84877983328 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast
    • Fukushima, E.O., Seki, H., Sawai, S., Suzuki, M., Ohyama, K., Saito, K., et al. (2013) Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast. Plant Cell Physiol. 54: 740-749.
    • (2013) Plant Cell Physiol , vol.54 , pp. 740-749
    • Fukushima, E.O.1    Seki, H.2    Sawai, S.3    Suzuki, M.4    Ohyama, K.5    Saito, K.6
  • 17
    • 84883335229 scopus 로고    scopus 로고
    • Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants
    • Geisler, K., Hughes, R.K., Sainsbury, F., Lomonossoff, G.P., Rejzek, M., Fairhurst, S., et al. (2013) Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proc. Natl Acad. Sci. USA 110: E3360-E3367.
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E3360-E3367
    • Geisler, K.1    Hughes, R.K.2    Sainsbury, F.3    Lomonossoff, G.P.4    Rejzek, M.5    Fairhurst, S.6
  • 18
    • 84866386264 scopus 로고    scopus 로고
    • Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng
    • Han, J.Y., Hwang, H.S., Choi, S.W., Kim, H.J. and Choi, Y.E. (2012) Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 53: 1535-1545.
    • (2012) Plant Cell Physiol , vol.53 , pp. 1535-1545
    • Han, J.Y.1    Hwang, H.S.2    Choi, S.W.3    Kim, H.J.4    Choi, Y.E.5
  • 19
    • 83255165496 scopus 로고    scopus 로고
    • The cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng
    • Han, J.Y., Kim, H.J., Kwon, Y.S. and Choi, Y.E. (2011) The cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 52: 2062-2073.
    • (2011) Plant Cell Physiol , vol.52 , pp. 2062-2073
    • Han, J.Y.1    Kim, H.J.2    Kwon, Y.S.3    Choi, Y.E.4
  • 20
    • 84890471488 scopus 로고    scopus 로고
    • The involvement of b-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng
    • Han, J.Y., Kim, M.J., Ban, Y.W., Hwang, H.S. and Choi, Y.E. (2013) The involvement of b-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 54: 2034-2046.
    • (2013) Plant Cell Physiol , vol.54 , pp. 2034-2046
    • Han, J.Y.1    Kim, M.J.2    Ban, Y.W.3    Hwang, H.S.4    Choi, Y.E.5
  • 21
    • 66649122600 scopus 로고    scopus 로고
    • Economic importance of licorice
    • Hayashi, H. and Sudo, H. (2009) Economic importance of licorice. Plant Biotechnol. 26: 101-104.
    • (2009) Plant Biotechnol , vol.26 , pp. 101-104
    • Hayashi, H.1    Sudo, H.2
  • 22
    • 84868091024 scopus 로고    scopus 로고
    • Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus
    • Huang, L., Li, J., Ye, H., Li, C., Wang, H., Liu, B., et al. (2012) Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta 236: 1571-1581.
    • (2012) Planta , vol.236 , pp. 1571-1581
    • Huang, L.1    Li, J.2    Ye, H.3    Li, C.4    Wang, H.5    Liu, B.6
  • 23
    • 0034490132 scopus 로고    scopus 로고
    • Indole alkaloid biosynthesis in Catharanthus roseus: New enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase
    • Irmler, S., Schröder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., et al. (2000) Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J. 24: 797-804.
    • (2000) Plant J , vol.24 , pp. 797-804
    • Irmler, S.1    Schröder, G.2    St-Pierre, B.3    Crouch, N.P.4    Hotze, M.5    Schmidt, J.6
  • 24
    • 84922463116 scopus 로고    scopus 로고
    • Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd
    • Jung, S.C., Kim, W., Park, S.C., Jeong, J., Park, M.K., Lim, S., et al. (2014) Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd. Plant Cell Physiol. 55: 2177-2188.
    • (2014) Plant Cell Physiol , vol.55 , pp. 2177-2188
    • Jung, S.C.1    Kim, W.2    Park, S.C.3    Jeong, J.4    Park, M.K.5    Lim, S.6
  • 25
    • 0036664733 scopus 로고    scopus 로고
    • Licorice root. A natural sweetener and an important ingredient in Chinese medicine
    • Kitagawa, I. (2002) Licorice root. A natural sweetener and an important ingredient in Chinese medicine. Pure Appl. Chem. 74: 1189-1198.
    • (2002) Pure Appl. Chem , vol.74 , pp. 1189-1198
    • Kitagawa, I.1
  • 26
    • 77952922442 scopus 로고    scopus 로고
    • In vitro proliferation and triterpenoid characteristics of licorice (Glycyrrhiza uralensis Fischer, Leguminosae) stolons
    • Kojoma, M., Ohyama, K., Seki, H., Hiraoka, Y., Asazu, S.N., Sawa, S., et al. (2010) In vitro proliferation and triterpenoid characteristics of licorice (Glycyrrhiza uralensis Fischer, Leguminosae) stolons. Plant Biotechnol. 27: 59-66.
    • (2010) Plant Biotechnol , vol.27 , pp. 59-66
    • Kojoma, M.1    Ohyama, K.2    Seki, H.3    Hiraoka, Y.4    Asazu, S.N.5    Sawa, S.6
  • 27
    • 84885433874 scopus 로고    scopus 로고
    • A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis
    • Krokida, A., Delis, C., Geisler, K., Garagounis, C., Tsikou, D., Penã-Rodŕguez, L.M., et al. (2013) A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis. New Phytol. 200: 675-690.
    • (2013) New Phytol , vol.200 , pp. 675-690
    • Krokida, A.1    Delis, C.2    Geisler, K.3    Garagounis, C.4    Tsikou, D.5    Penã-Rodŕguez, L.M.6
  • 28
    • 77956655047 scopus 로고    scopus 로고
    • Chemical study and medical application of saponins as anti-cancer agents
    • Man, S., Gao, W., Zhang, Y., Huang, L. and Liu, C. (2010) Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia 81: 703-714.
    • (2010) Fitoterapia , vol.81 , pp. 703-714
    • Man, S.1    Gao, W.2    Zhang, Y.3    Huang, L.4    Liu, C.5
  • 30
    • 5344253288 scopus 로고    scopus 로고
    • Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line
    • Matsui, S., Matsumoto, H., Sonoda, Y., Ando, K., Aizu-Yokota, E., Sato, T., et al. (2004) Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Int. Immunopharmacol. 4: 1633-1644.
    • (2004) Int. Immunopharmacol , vol.4 , pp. 1633-1644
    • Matsui, S.1    Matsumoto, H.2    Sonoda, Y.3    Ando, K.4    Aizu-Yokota, E.5    Sato, T.6
  • 31
    • 34247267753 scopus 로고    scopus 로고
    • Saponin biosynthesis in Saponaria vaccaria cDNAs encoding bamyrin synthase and a triterpene carboxylic acid glucosyltransferase
    • Meesapyodsuk, D., Balsevich, J., Reed, D.W. and Covello, P.S. (2007) Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding bamyrin synthase and a triterpene carboxylic acid glucosyltransferase. Plant Physiol. 143: 959-969.
    • (2007) Plant Physiol , vol.143 , pp. 959-969
    • Meesapyodsuk, D.1    Balsevich, J.2    Reed, D.W.3    Covello, P.S.4
  • 33
    • 77952516353 scopus 로고    scopus 로고
    • Diversification of P450 genes during land plant evolution
    • Mizutani, M. and Ohta, D. (2010) Diversification of P450 genes during land plant evolution. Annu. Rev. Plant Biol. 61: 291-315.
    • (2010) Annu. Rev. Plant Biol , vol.61 , pp. 291-315
    • Mizutani, M.1    Ohta, D.2
  • 34
    • 84893351504 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16a hydroxylase from Bupleurum falcatum
    • Moses, T., Pollier, J., Almagro, L., Buyst, D., Van Montagu, M., Pedrenõ, M.A., et al. (2014a) Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16a hydroxylase from Bupleurum falcatum. Proc. Natl Acad. Sci. USA 111: 1634-1639.
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 1634-1639
    • Moses, T.1    Pollier, J.2    Almagro, L.3    Buyst, D.4    Van Montagu, M.5    Pedrenõ, M.A.6
  • 35
    • 84922980653 scopus 로고    scopus 로고
    • Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata
    • Moses, T., Pollier, J., Faizal, A., Apers, S., Pieters, L., Thevelein, J.M., et al. (2015a) Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata. Mol. Plant 8: 122-135.
    • (2015) Mol. Plant , vol.8 , pp. 122-135
    • Moses, T.1    Pollier, J.2    Faizal, A.3    Apers, S.4    Pieters, L.5    Thevelein, J.M.6
  • 36
    • 84923041998 scopus 로고    scopus 로고
    • OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua
    • Moses, T., Pollier, J., Shen, Q., Soetaert, S., Reed, J., Erffelinck, M.-L., et al. (2015b) OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua. Plant Cell 27: 286-301.
    • (2015) Plant Cell , vol.27 , pp. 286-301
    • Moses, T.1    Pollier, J.2    Shen, Q.3    Soetaert, S.4    Reed, J.5    Erffelinck, M.-L.6
  • 37
    • 84911462444 scopus 로고    scopus 로고
    • Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids
    • Moses, T., Thevelein, J.M., Goossens, A. and Pollier, J. (2014b) Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids. Phytochemistry 108: 47-56.
    • (2014) Phytochemistry , vol.108 , pp. 47-56
    • Moses, T.1    Thevelein, J.M.2    Goossens, A.3    Pollier, J.4
  • 38
    • 77953200019 scopus 로고    scopus 로고
    • Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula
    • Naoumkina, M.A., Modolo, L.V., Huhman, D.V., Urbanczyk-Wochniak, E., Tang, Y., Sumner, L.W., et al. (2010) Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula. Plant Cell 22: 850-866.
    • (2010) Plant Cell , vol.22 , pp. 850-866
    • Naoumkina, M.A.1    Modolo, L.V.2    Huhman, D.V.3    Urbanczyk-Wochniak, E.4    Tang, Y.5    Sumner, L.W.6
  • 39
    • 79953234390 scopus 로고    scopus 로고
    • A P450-centric view of plant evolution
    • Nelson, D. and Werck-Reichhart, D. (2011) A P450-centric view of plant evolution. Plant J. 66: 194-211.
    • (2011) Plant J , vol.66 , pp. 194-211
    • Nelson, D.1    Werck-Reichhart, D.2
  • 40
    • 79953254244 scopus 로고    scopus 로고
    • Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus
    • Sawai, S., Uchiyama, H., Mizuno, S., Aoki, T., Akashi, T., Ayabe, S., et al. (2011) Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus. FEBS Lett. 585: 1031-1036.
    • (2011) FEBS Lett , vol.585 , pp. 1031-1036
    • Sawai, S.1    Uchiyama, H.2    Mizuno, S.3    Aoki, T.4    Akashi, T.5    Ayabe, S.6
  • 41
    • 84889103030 scopus 로고    scopus 로고
    • Virus-induced gene silencing identifies Catharanthus roseus 7-deoxyloganic acid-7-hydroxylase, a step in iridoid and monoterpene indole alkaloid biosynthesis
    • Salim, V., Yu, F., Altarejos, J. and De Luca, V. (2013) Virus-induced gene silencing identifies Catharanthus roseus 7-deoxyloganic acid-7-hydroxylase, a step in iridoid and monoterpene indole alkaloid biosynthesis. Plant J. 76: 754-765.
    • (2013) Plant J , vol.76 , pp. 754-765
    • Salim, V.1    Yu, F.2    Altarejos, J.3    De Luca, V.4
  • 42
    • 84863085006 scopus 로고    scopus 로고
    • The Sg-1 glycosyltransferase locus regulates structural diversity of triterpenoid saponins of soybean
    • Sayama, T., Ono, E., Takagi, K., Takada, Y., Horikawa, M., Nakamoto, Y., et al. (2012) The Sg-1 glycosyltransferase locus regulates structural diversity of triterpenoid saponins of soybean. Plant Cell 24: 2123-2138.
    • (2012) Plant Cell , vol.24 , pp. 2123-2138
    • Sayama, T.1    Ono, E.2    Takagi, K.3    Takada, Y.4    Horikawa, M.5    Nakamoto, Y.6
  • 43
    • 52949093520 scopus 로고    scopus 로고
    • Licorice b-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin
    • Seki, H., Ohyama, K., Sawai, S., Mizutani, M., Ohnishi, T., Sudo, H., et al. (2008) Licorice b-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc. Natl Acad. Sci. USA 105: 14204-14209.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 14204-14209
    • Seki, H.1    Ohyama, K.2    Sawai, S.3    Mizutani, M.4    Ohnishi, T.5    Sudo, H.6
  • 44
    • 84855180697 scopus 로고    scopus 로고
    • Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin
    • Seki, H., Sawai, S., Ohyama, K., Mizutani, M., Ohnishi, T., Sudo, H., et al. (2011) Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell 23: 4112-4123.
    • (2011) Plant Cell , vol.23 , pp. 4112-4123
    • Seki, H.1    Sawai, S.2    Ohyama, K.3    Mizutani, M.4    Ohnishi, T.5    Sudo, H.6
  • 45
    • 33644949950 scopus 로고    scopus 로고
    • Identification of b-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay
    • Shibuya, M., Hoshino, M., Katsube, Y., Hayashi, H., Kushiro, T. and Ebiduka, Y. (2006) Identification of b-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay. FEBS J. 273: 948-959.
    • (2006) FEBS J , vol.273 , pp. 948-959
    • Shibuya, M.1    Hoshino, M.2    Katsube, Y.3    Hayashi, H.4    Kushiro, T.5    Ebiduka, Y.6
  • 46
    • 77952953046 scopus 로고    scopus 로고
    • Identification and characterization of glycosyltransferases involved in the biosynthesis of soyasaponin i in Glycine max
    • Shibuya, M., Nishimura, K., Yasuyama, N. and Ebizuka, Y. (2010) Identification and characterization of glycosyltransferases involved in the biosynthesis of soyasaponin I in Glycine max. FEBS Lett. 584: 2258-2264.
    • (2010) FEBS Lett , vol.584 , pp. 2258-2264
    • Shibuya, M.1    Nishimura, K.2    Yasuyama, N.3    Ebizuka, Y.4
  • 47
    • 77954662168 scopus 로고    scopus 로고
    • Effect and mechanism of AR-6 in experimental rheumatoid arthritis
    • Sun, S.X., Li, Y.M., Fang, W.R., Cheng, P., Liu, L. and Li, F. (2010) Effect and mechanism of AR-6 in experimental rheumatoid arthritis. Clin. Exp. Med. 10: 113-121.
    • (2010) Clin. Exp. Med , vol.10 , pp. 113-121
    • Sun, S.X.1    Li, Y.M.2    Fang, W.R.3    Cheng, P.4    Liu, L.5    Li, F.6
  • 48
    • 84874329092 scopus 로고    scopus 로고
    • Genetic and chemical analysis of a key biosynthetic step for soyasapogenol A, an aglycone of group A saponins that influence soymilk flavor
    • Takada, Y., Sasama, H., Sayama, T., Kikuchi, A., Kato, S. Ishimono, M., et al. (2013) Genetic and chemical analysis of a key biosynthetic step for soyasapogenol A, an aglycone of group A saponins that influence soymilk flavor. Theor. Appl. Genet. 126: 721-731.
    • (2013) Theor. Appl. Genet , vol.126 , pp. 721-731
    • Takada, Y.1    Sasama, H.2    Sayama, T.3    Kikuchi, A.4    Kato Ishimono, S.M.5
  • 50
    • 77956918452 scopus 로고    scopus 로고
    • Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: Enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids
    • Wang Z., Yeats T., Han H., Jetter R. (2010) Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids. J. Biol. Chem. 285: 29703-29712.
    • (2010) J. Biol. Chem , vol.285 , pp. 29703-29712
    • Wang, Z.1    Yeats, T.2    Han, H.3    Jetter, R.4
  • 51
    • 85019179002 scopus 로고    scopus 로고
    • Cytochrome P450-enzymes involved in the biosynthesis of mono-and sesquiterpenes
    • Weitzel, C. and Simonsen, H.T. (2013) Cytochrome P450-enzymes involved in the biosynthesis of mono-and sesquiterpenes. Phytochem. Rev. 1-18.
    • (2013) Phytochem. Rev. , pp. 1-18
    • Weitzel, C.1    Simonsen, H.T.2
  • 52
    • 84879541446 scopus 로고    scopus 로고
    • Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest
    • Xiao, M., Zhang, Y., Chen, X., Lee, E.-J., Barber, C.J.S., Chakrabarty, R., et al. (2013) Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest. J. Biotechnol. 166: 122-134.
    • (2013) J. Biotechnol , vol.166 , pp. 122-134
    • Xiao, M.1    Zhang, Y.2    Chen, X.3    Lee, E.-J.4    Barber, C.J.S.5    Chakrabarty, R.6
  • 53
    • 0742307297 scopus 로고    scopus 로고
    • On the origins of triterpenoid skeletal diversity
    • Xu, R., Fazio, G.C. and Matsuda, S.P.T. (2004) On the origins of triterpenoid skeletal diversity. Phytochemistry 65: 261-291.
    • (2004) Phytochemistry , vol.65 , pp. 261-291
    • Xu, R.1    Fazio, G.C.2    Matsuda, S.P.T.3
  • 54
    • 84901857149 scopus 로고    scopus 로고
    • Production of bioactive ginsenoside compound K in metabolically engineered yeast
    • Yan, X., Fan, Y., Wei, W., Wang, P., Liu, Q., Wei, Y., et al. (2014) Production of bioactive ginsenoside compound K in metabolically engineered yeast. Cell Res. 24: 770-773.
    • (2014) Cell Res , vol.24 , pp. 770-773
    • Yan, X.1    Fan, Y.2    Wei, W.3    Wang, P.4    Liu, Q.5    Wei, Y.6
  • 55
    • 79953247573 scopus 로고    scopus 로고
    • An evolutionary view of functional diversity in family 1 glycosyltransferases
    • Yonekura-Sakakibara, K. and Hanada, K. (2011) An evolutionary view of functional diversity in family 1 glycosyltransferases. Plant J. 66: 182-193.
    • (2011) Plant J , vol.66 , pp. 182-193
    • Yonekura-Sakakibara, K.1    Hanada, K.2
  • 56
    • 84893662632 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cytochrome P450 taxoid 9a-hydroxylase in Ginkgo biloba cells
    • Zhang, N., Han, Z., Sun, G., Hoffman, A., Wilson, I.W., Yang, Y., et al. (2014) Molecular cloning and characterization of a cytochrome P450 taxoid 9a-hydroxylase in Ginkgo biloba cells. Biochem. Biophys. Res. Commun. 443: 938-943.
    • (2014) Biochem. Biophys. Res. Commun , vol.443 , pp. 938-943
    • Zhang, N.1    Han, Z.2    Sun, G.3    Hoffman, A.4    Wilson, I.W.5    Yang, Y.6
  • 57
    • 41149154271 scopus 로고    scopus 로고
    • Antihepatitis B virus activities of triterpenoid saponin compound from Potentilla anserine L
    • Zhao, Y.L., Cai, G.M., Hong, X., Shan, L.M. and Xiao, X.H. (2008) Antihepatitis B virus activities of triterpenoid saponin compound from Potentilla anserine L. Phytomedicine 15: 253-258.
    • (2008) Phytomedicine , vol.15 , pp. 253-258
    • Zhao, Y.L.1    Cai, G.M.2    Hong, X.3    Shan, L.M.4    Xiao, X.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.