The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation

CNS Neuroscience and Therapeutics

Volumn 21, Issue 9, 2015, Pages 708-717

  Wang, Wei Ming ^a,b   Liu, Zhao ^a   Liu, Ai Jun ^b   Wang, Yu Xiang ^a   Wang, Hong Gang ^a   An, Di ^a   Heng, Bin ^a   Xie, Lai Hua ^c   Duan, Jun Li ^d   Liu, Yan Qiang ^a  

^a NANKAI UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Excitotoxicity; Free Zn2+; Hypoxia ischemia; Inflammation; Oxidative stress; TPEN

Indexed keywords

AMPA RECEPTOR; GLUR2 PROTEIN; INTERLEUKIN 6; MALONALDEHYDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; NITRIC OXIDE SYNTHASE; NR2 PROTEIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; CHELATING AGENT; ETHYLENEDIAMINE DERIVATIVE; GLUCOSE; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE; NEUROPROTECTIVE AGENT; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; RAT; ANIMAL; BRAIN; CELL HYPOXIA; CEREBRAL ARTERY DISEASE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; IMMUNOMODULATION; ISCHEMIA; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; CHELATING AGENTS; DISEASE MODELS, ANIMAL; ETHYLENEDIAMINES; FEMALE; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIA; NEUROIMMUNOMODULATION; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; RATS; RATS, INBRED SHR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; ZINC;

EID: 84939269382     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12428     Document Type: Article

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