A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo

Neuropharmacology

Volumn 85, Issue , 2014, Pages 517-527

  Nuñez Figueredo, Yanier ^a   Ramírez Sánchez, Jeney ^a   Hansel, Gisele ^b   Simões Pires, Elisa Nicoloso ^b   Merino, Nelson ^a   Valdes, Odalys ^a   Delgado Hernández, René ^a   Parra, Alicia Lagarto ^a   Ochoa Rodríguez, Estael ^c   Verdecia Reyes, Yamila ^c   Salbego, Christianne ^b   Costa, Silvia L ^d   Souza, Diogo O ^b   Pardo Andreu, Gilberto L ^e  

^a CENTRO DE INVESTIGACIÓN Y DESARROLLO DE MEDICAMENTOS CIDEM   (Cuba)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF HAVANA   (Cuba)

^d FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^e INSTITUTO DE FARMACIA Y ALIMENTOS   (Cuba)

Author keywords

Ischemia reperfusion injury; JM 20; Middle cerebral artery occlusion; Mitochondria; Neuroprotection; Oxygen glucose deprivation

Indexed keywords

3 ETHOXYCARBONYL 2 METHYL 4 (2 NITROPHENYL) 4,11 DIHYDRO 1H PYRIDO[2,3 B][1,5]BENZODIAZEPINE; ASPARTIC ACID; BENZODIAZEPINE DERIVATIVE; CALCIUM ION; CYTOCHROME C; GLUTAMIC ACID; HYDROGEN PEROXIDE; JM 20; UNCLASSIFIED DRUG; 3-ETHOXYCARBONYL-2-METHYL-4-(2-NITROPHENYL)-4,11-DIHYDRO-1H-PYRIDO(2,3-B)(1,5)BENZODIAZEPINE; EXCITATORY AMINO ACID; GLUCOSE; NEUROPROTECTIVE AGENT; NICOTINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CELL ORGANELLE; CELL STRUCTURE; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; HIPPOCAMPUS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CELL DEATH; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; TISSUE CULTURE TECHNIQUE; WISTAR RAT;

ANIMALS; BENZODIAZEPINES; BRAIN; BRAIN ISCHEMIA; CELL DEATH; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACIDS; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; NIACIN; RANDOM ALLOCATION; RATS, WISTAR; TISSUE CULTURE TECHNIQUES;

EID: 84903840522     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.06.009     Document Type: Article

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