Neuroprotective efficiency of NMDA receptor blockade in the striatum and CA3 hippocampus after various durations of cerebral ischemia in gerbils

Acta Physiologica Hungarica

Volumn 98, Issue 1, 2011, Pages 32-44

  Radenovic, L ^a   Selakovic, V ^b   Janac, B ^a   Andjus, Pavle R ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

brain damage; confocal microscopy; functional recovery; Mongolian gerbils; neuroprotection; NMDA antagonist; stroke

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN ISCHEMIA; BRAIN SLICE; CAROTID ARTERY OBSTRUCTION; COMMON CAROTID ARTERY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; DRUG EFFICACY; GERBIL; HIPPOCAMPAL CA3 REGION; IN VIVO STUDY; LOW DRUG DOSE; MALE; MONGOLIA; NERVE CELL LESION; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; REPERFUSION; STROKE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CA3 REGION, HIPPOCAMPAL; CORPUS STRIATUM; DIZOCILPINE MALEATE; GERBILLINAE; MALE; NEUROPROTECTIVE AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; REPERFUSION;

EID: 79952584237     PISSN: 0231424X     EISSN: 15882683     Source Type: Journal    
DOI: 10.1556/APhysiol.98.2011.1.5     Document Type: Article

References (35)

1. Allaf R, Vistelle R, Boulu RG: Inefficacy of N-methyl-D-aspartate receptor complex antagonists on behavioral and histologic consequences of global cerebral ischemia in rats. Ann. Pharm. Fr. 58, 266-270 (2000) (Pubitemid 30601504)
2. Buchan A, Pulsinelli WA: Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J. Neurosci. 10, 311-316 (1990) (Pubitemid 20059267)
3. Chung YH, Shin CM, Kim MJ, Shin DH, Yoo YB, Cha CI: Spatial and temporal distribution of N-type Ca2+channels in gerbil global cerebral ischemia. Brain Res. 902, 294-300 (2001) (Pubitemid 32510880)
4. Corbett D, Evans S, Thomas C, Wang D, Jonas RA: MK-801 reduced cerebral ischemic injury by inducing hypothermia. Brain Res. 514, 300-304 (1990) (Pubitemid 20151380)
5. Dietrich WD, Busto R, Globus MY, Ginsberg MD: Brain damage and temperature: cellular and molecular mechanisms. Adv. Neurol. 71, 177-197 (1996)
6. Gerasimov VD, Artemenko DP, Krishtal OA: Therapeutic time window for the neuroprotective action of MK- 801 after decapitation ischemia: hippocampal slice data. Brain Res. 1017, 92-97 (2004) (Pubitemid 38917148)
7. Gerriets T, Stolz E, Walberer M, Kaps M, Bachmann G, Fisher M: Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance. Stroke 34, 2234-2239 (2003) (Pubitemid 37099842)
8. Gill R, Woodruff GN: The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia. Eur. J. Pharmacol. 176, 143-149 (1990) (Pubitemid 20041285)
9. Gill R, Foster AC, Woodruff GN: Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J. Neurosci. 7, 3343-3349 (1987)
10. Janac B, Radenovic L, Selakovic V, Prolic Z: Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia. Behav. Brain Res. 175, 362-373 (2006) (Pubitemid 44750240)
11. Janac B, Selakovic V, Radenovic L: Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia. Behav. Brain Res. 194, 72-78 (2008)
12. Kitagawa K, Matsumoto M, Kuwabara K, Tagaya M, Ohtsuki T, Hata R, Ueda H, Handa N, Kimura K, Kamada T: 'Ischemic tolerance' phenomenon detected in various brain regions. Brain Res. 561, 203-211 (1991)
13. Kuroiwa T, Bonnekoh P, Hossmann KA: Prevention of postischemic hyperthermia prevents ischemic injury of CA1 neurons in gerbils. J. Cereb. Blood Flow Metab. 10, 550-556 (1990) (Pubitemid 20209201)
14. Li MM, Payne RS, Reid KH, Tseng MT, Rigor BM, Schurr A: Correlates of delayed neuronal damage and neuroprotection in a rat model of cardiac-arrest-induced cerebral ischemia. Brain Res. 826, 44-52 (1999) (Pubitemid 29222958)
15. Lin B, Dietrich WD, Ginsberg MD, Globus MY, Busto R: MK-801 (dizocilpine) protects the brain from repeated normothermic global ischemic insults in the rat. J. Cereb. Blood Flow Metab. 13, 925-932 (1993) (Pubitemid 23312639)
16. Lipton P: Ischemic cell death in brain neurons. Physiol. Rev. 79, 1431-1568 (1999) (Pubitemid 29473320)
17. Malva JO, Ambrosio AF, Cunha RA, Ribeiro JA, Carvalho AP, Carvalho CM: A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion. Neurosci. Lett. 185, 83-86 (1995)
18. Mehta S, Manhas N, Raghubir R: Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev. 54, 34-66 (2007) (Pubitemid 46498164)
19. Monaghan DT, Cotman CW: Distribution of N-methyl-D-aspartate sensitive l-(3H)glutamate-binding sites in rat brain. J. Neurosci. 5, 2909-2919 (1985) (Pubitemid 16225491)
20. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540 (1994) (Pubitemid 24100885)
21. Moyanova SG, Kortenska LV, Mitreva RG, Pashova VD, Ngomba RT, Nicoletti F: Multimodel assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Res. 1153, 58-67 (2007) (Pubitemid 46823888)
22. Murase K, Kato H, Kogure K: Limited but evident protective effects of MK-801 and pentobarbital on neuronal damage following forebrain ischemia in the gerbil under normothermic conditions. Neurosci. Lett. 149, 229-232 (1993) (Pubitemid 23036922)
23. Pforte C, Henrich-Noack P, Baldauf K, Reymann KG: Increase in proliferation and gliogenesis but decrease of early neurogenesis in the rat forebrain shortly after transient global ischemia. Neuroscience 136, 1133-1146 (2005) (Pubitemid 41790526)
24. Radenovic L, Selakovic V, Andjus PR: Neuroprotection by MK-801 following cerebral ischemia in Mongolian gerbils. Arch. Biol. Sci. 60, 341-346 (2008)
25. Rod MR, Whishaw IQ, Auer RN: The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801. Can. J. Psychol. 44, 196-209 (1990)
26. Sattler R, Tymianski M: Molecular mechanisms of Ca2+-dependent excitotoxicity. J. Mol. Med. 78, 3-13 (2000)
27. Schmidt-Kastner R, Freund TF: Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 40, 599-636 (1991)
28. Schurr A, Payne RS, Rigor BM: Synergism between diltiazem and MK-801 but not APV in protecting hippocampal slices against hypoxic damage. Brain Res. 684, 233-236 (1995)
29. Sheardown MJ, Suzdak PD, Nordholm L: AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischemia, even when delayed 24 hours. Eur. J. Pharmacol. 236, 347-353 (1993) (Pubitemid 23170373)
30. Standaert DG, Landwehrmeyer GB, Kerner JA, Penney JBJr, Young AB: Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus. Brain Res. Mol. Brain Res. 42, 89-102 (1996) (Pubitemid 26345410)
31. Villmann C, Becker CM: On the hypes and falls in neuroprotection: targeting the NMDA receptor. Neuroscientist 13, 616-625 (2007)
32. Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, Sub AY: Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 958, 439-447 (2002) (Pubitemid 35441199)
33. Warner MA, Neill KH, Nadler JV, Crain BJ: Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil. J. Cereb. Blood Flow Metab. 11, 600-610 (1991)
34. Yokota M, Tani E, Tsubuki S, Yamaura I, Nakagaki I, Hori S, Saido TC: Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage. Brain Res. 819, 8-14 (1999) (Pubitemid 29225451)
35. Zhang L, Mitani A, Yanase H, Kataoka K: Continuous monitoring and regulating of brain temperature in the conscious and freely moving ischemic gerbil: effect of MK-801 on delayed neuronal death in hippocampal CA1. J. Neurosci. Res. 47, 440-448 (1997) (Pubitemid 27097758)