메뉴 건너뛰기




Volumn 40, Issue 8, 2015, Pages 1576-1582

Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer’s Disease

Author keywords

Alzheimer s disease; APP PS1 double transgenic mouse; Mitochondrial dysfunction; Sirt3

Indexed keywords

BETA ACTIN; MESSENGER RNA; SIRTUIN 3; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; SIRT3 PROTEIN, MOUSE;

EID: 84939260692     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1630-1     Document Type: Article
Times cited : (67)

References (32)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer’s disease: genes, proteins, and therapy
    • COI: 1:CAS:528:DC%2BD3MXislCrsLc%3D, PID: 11274343
    • Selkoe DJ (2001) Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81(2):741–766
    • (2001) Physiol Rev , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2cXmt1Gis7o%3D, PID: 15295589
    • Mattson MP (2004) Pathways towards and away from Alzheimer’s disease. Nature 430(7000):631–639
    • (2004) Nature , vol.430 , Issue.7000 , pp. 631-639
    • Mattson, M.P.1
  • 3
    • 84903304968 scopus 로고    scopus 로고
    • The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
    • COI: 1:CAS:528:DC%2BC3sXhsFOgu7zI, PID: 24071439
    • Swerdlow RH, Burns JM, Khan SM (2014) The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 1842(8):1219–1231
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.8 , pp. 1219-1231
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 4
    • 84860198618 scopus 로고    scopus 로고
    • Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
    • COI: 1:CAS:528:DC%2BC38XlvVGru7s%3D, PID: 22229260
    • Leuner K, Schütt T, Kurz C et al (2012) Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 16(12):1421–1433
    • (2012) Antioxid Redox Signal , vol.16 , Issue.12 , pp. 1421-1433
    • Leuner, K.1    Schütt, T.2    Kurz, C.3
  • 5
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: insights into their biological function
    • COI: 1:CAS:528:DC%2BD2sXks1ansr4%3D, PID: 17447894
    • Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404(1):1–13
    • (2007) Biochem J , vol.404 , Issue.1 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 6
    • 84886241829 scopus 로고    scopus 로고
    • Sirtuin deacetylases as therapeutic targets in the nervous system
    • COI: 1:CAS:528:DC%2BC3sXhs1ylurnL, PID: 24037427
    • Langley B, Sauve A (2013) Sirtuin deacetylases as therapeutic targets in the nervous system. Neurotherapeutics 10(4):605–620
    • (2013) Neurotherapeutics , vol.10 , Issue.4 , pp. 605-620
    • Langley, B.1    Sauve, A.2
  • 7
    • 33746824192 scopus 로고    scopus 로고
    • Neuronal sirt1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    • COI: 1:CAS:528:DC%2BD28XnsVOntLc%3D, PID: 16751189
    • Qin W, Yang T, Ho L et al (2006) Neuronal sirt1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 281(31):21745–21754
    • (2006) J Biol Chem , vol.281 , Issue.31 , pp. 21745-21754
    • Qin, W.1    Yang, T.2    Ho, L.3
  • 8
    • 34447308268 scopus 로고    scopus 로고
    • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
    • COI: 1:CAS:528:DC%2BD2sXnsFejt7k%3D, PID: 17581637
    • Kim D, Nguyen MD, Dobbin MM et al (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J 26(13):3169–3179
    • (2007) EMBO J , vol.26 , Issue.13 , pp. 3169-3179
    • Kim, D.1    Nguyen, M.D.2    Dobbin, M.M.3
  • 9
    • 84860809347 scopus 로고    scopus 로고
    • SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
    • COI: 1:CAS:528:DC%2BC38Xmt1Klsbs%3D, PID: 22533670
    • Giralt A, Villarroya F (2012) SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. Biochem J 444(1):1–10
    • (2012) Biochem J , vol.444 , Issue.1 , pp. 1-10
    • Giralt, A.1    Villarroya, F.2
  • 10
    • 84887020906 scopus 로고    scopus 로고
    • Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3
    • COI: 1:CAS:528:DC%2BC3sXnsFWhs78%3D
    • Brenmoehl J, Hoeflich A (2013) Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrial 13(6):755–761
    • (2013) Mitochondrial , vol.13 , Issue.6 , pp. 755-761
    • Brenmoehl, J.1    Hoeflich, A.2
  • 11
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • COI: 1:CAS:528:DC%2BC3cXhsVygsLfI, PID: 21094524
    • Someya S, Yu W, Hallows WC et al (2010) Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143(5):802–812
    • (2010) Cell , vol.143 , Issue.5 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3
  • 12
    • 84880649206 scopus 로고    scopus 로고
    • Hypoxia-up-regulated mitochondrial movement regulator does not contribute to the APP/PS1 double transgenic mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhsFelsLrN, PID: 23900018
    • Zou Y, Li Y, Yu W et al (2013) Hypoxia-up-regulated mitochondrial movement regulator does not contribute to the APP/PS1 double transgenic mouse model of Alzheimer’s disease. Dement Geriatr Cogn Disord 36(3–4):137–145
    • (2013) Dement Geriatr Cogn Disord , vol.36 , Issue.3-4 , pp. 137-145
    • Zou, Y.1    Li, Y.2    Yu, W.3
  • 13
    • 84904987120 scopus 로고    scopus 로고
    • Evidences for B6C3-Tg (APPswe/PSEN1dE9) double-transgenic mice between 3 and 10 months as an age-related Alzheimer’s disease model
    • COI: 1:CAS:528:DC%2BC3sXhvFOmtr%2FI, PID: 24362678
    • Zhong Z, Yang L, Wu X et al (2014) Evidences for B6C3-Tg (APPswe/PSEN1dE9) double-transgenic mice between 3 and 10 months as an age-related Alzheimer’s disease model. J Mol Neurosci 53(3):370–376
    • (2014) J Mol Neurosci , vol.53 , Issue.3 , pp. 370-376
    • Zhong, Z.1    Yang, L.2    Wu, X.3
  • 14
    • 84923576594 scopus 로고    scopus 로고
    • Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence
    • COI: 1:CAS:528:DC%2BC2MXkvFShtbc%3D, PID: 25595289
    • Glover AR, Zhao JT, Ip JC et al (2015) Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence. Endocr Relat Cancer 22(1):99–109
    • (2015) Endocr Relat Cancer , vol.22 , Issue.1 , pp. 99-109
    • Glover, A.R.1    Zhao, J.T.2    Ip, J.C.3
  • 15
    • 84960388257 scopus 로고    scopus 로고
    • Effects of beta-amyloid on resting state functional connectivity within and between networks reflect known patterns of regional vulnerability
    • Elman JA, Madison CM, Baker SL, et al (2014) Effects of beta-amyloid on resting state functional connectivity within and between networks reflect known patterns of regional vulnerability. Cereb Cortex. doi:10.1093/cercor/bhu259
    • (2014) Cereb Cortex
    • Elman, J.A.1    Madison, C.M.2    Baker, S.L.3
  • 16
    • 84919333467 scopus 로고    scopus 로고
    • Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2MXht1Oqtrw%3D, PID: 25500142
    • Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson DA (2015) Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer’s disease. Exp Neurol 264:82–91
    • (2015) Exp Neurol , vol.264 , pp. 82-91
    • Xu, W.1    Fitzgerald, S.2    Nixon, R.A.3    Levy, E.4    Wilson, D.A.5
  • 17
    • 34247271282 scopus 로고    scopus 로고
    • +-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
    • COI: 1:CAS:528:DC%2BD2sXkslKjtLk%3D, PID: 17437997
    • +-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev 21(8):920–928
    • (2007) Genes Dev , vol.21 , Issue.8 , pp. 920-928
    • Scher, M.B.1    Vaquero, A.2    Reinberg, D.3
  • 18
    • 84871852995 scopus 로고    scopus 로고
    • SIRT3 functions in the nucleus in the control of stress-related gene expression
    • COI: 1:CAS:528:DC%2BC38XhvVWgu7zE, PID: 23045395
    • Iwahara T, Bonasio R, Narendra V, Reinberg D (2012) SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol 32(24):5022–5034
    • (2012) Mol Cell Biol , vol.32 , Issue.24 , pp. 5022-5034
    • Iwahara, T.1    Bonasio, R.2    Narendra, V.3    Reinberg, D.4
  • 19
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • COI: 1:CAS:528:DC%2BD3cXotFGltb0%3D, PID: 11089981
    • Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408(6809):239–247
    • (2000) Nature , vol.408 , Issue.6809 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 20
    • 84903954827 scopus 로고    scopus 로고
    • Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons
    • Summers DW, DiAntonio A, Milbrandt J (2014) Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons. J Neurosci 9;34(28):9338–9350
    • (2014) J Neurosci 9;34(28) , pp. 9338-9350
    • Summers, D.W.1    DiAntonio, A.2    Milbrandt, J.3
  • 21
    • 84901352729 scopus 로고    scopus 로고
    • Distinct patterns of sirtuin expression during progression of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXhtlSgtb4%3D, PID: 24464653
    • Lutz MI, Milenkovic I, Regelsberger G, Kovacs GG (2014) Distinct patterns of sirtuin expression during progression of Alzheimer’s disease. Neuromolecular Med 16(2):405–414
    • (2014) Neuromolecular Med , vol.16 , Issue.2 , pp. 405-414
    • Lutz, M.I.1    Milenkovic, I.2    Regelsberger, G.3    Kovacs, G.G.4
  • 22
    • 84919916896 scopus 로고    scopus 로고
    • Mitochondrial sirtuins: emerging roles in metabolic regulations, energy homeostasis and diseases
    • Parihar P, Solanki I, Mansuri ML, Parihar MS (2015) Mitochondrial sirtuins: emerging roles in metabolic regulations, energy homeostasis and diseases. Exp Gerontol 61C:130–141
    • (2015) Exp Gerontol , vol.61C , pp. 130-141
    • Parihar, P.1    Solanki, I.2    Mansuri, M.L.3    Parihar, M.S.4
  • 23
    • 69249211284 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice
    • COI: 1:CAS:528:DC%2BD1MXhtVKgsL%2FO, PID: 18295378
    • Hauptmann S, Scherping I, Dröse S et al (2009) Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30(10):1574–1586
    • (2009) Neurobiol Aging , vol.30 , Issue.10 , pp. 1574-1586
    • Hauptmann, S.1    Scherping, I.2    Dröse, S.3
  • 24
    • 84863245760 scopus 로고    scopus 로고
    • Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38Xjs12mu70%3D, PID: 22393443
    • Trushina E, Nemutlu E, Zhang S et al (2012) Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer’s disease. PLoS One 7(2):e32737
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e32737
    • Trushina, E.1    Nemutlu, E.2    Zhang, S.3
  • 25
    • 84895089601 scopus 로고    scopus 로고
    • Age-related decrease in the mitochondrial sirtuin deacetylase sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model
    • PID: 24505357
    • Zeng L, Yang Y, Hu Y et al (2014) Age-related decrease in the mitochondrial sirtuin deacetylase sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. PLoS One 9(2):e88019
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e88019
    • Zeng, L.1    Yang, Y.2    Hu, Y.3
  • 26
    • 19944433088 scopus 로고    scopus 로고
    • A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    • COI: 1:CAS:528:DC%2BD2MXotVKitw%3D%3D, PID: 15676284
    • Bellizzi D, Rose G, Cavalcante P et al (2005) A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85(2):258–263
    • (2005) Genomics , vol.85 , Issue.2 , pp. 258-263
    • Bellizzi, D.1    Rose, G.2    Cavalcante, P.3
  • 27
    • 55749084738 scopus 로고    scopus 로고
    • A role for the mitochondrial deacetylase sirt3 in regulating energy homeostasis
    • COI: 1:CAS:528:DC%2BD1cXht1SgtrbL, PID: 18794531
    • Ahn BH, Kim HS, Song S et al (2008) A role for the mitochondrial deacetylase sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 105(38):14447–14452
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.38 , pp. 14447-14452
    • Ahn, B.H.1    Kim, H.S.2    Song, S.3
  • 28
    • 84867534243 scopus 로고    scopus 로고
    • Susceptibility of mitochondrial electron-transport complexes to oxidative damage. Focus on cytochrome c oxidase
    • COI: 1:CAS:528:DC%2BC38XhsV2ktbbN, PID: 22856385
    • Musatov A, Robinson NC (2012) Susceptibility of mitochondrial electron-transport complexes to oxidative damage. Focus on cytochrome c oxidase. Free Radic Res 46(11):1313–1326
    • (2012) Free Radic Res , vol.46 , Issue.11 , pp. 1313-1326
    • Musatov, A.1    Robinson, N.C.2
  • 29
    • 84893981123 scopus 로고    scopus 로고
    • Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXhtFKls7g%3D, PID: 24217272
    • Francis BM, Yang J, Song BJ et al (2014) Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer’s disease. J Alzheimers Dis 39(2):347–355
    • (2014) J Alzheimers Dis , vol.39 , Issue.2 , pp. 347-355
    • Francis, B.M.1    Yang, J.2    Song, B.J.3
  • 30
    • 84916632737 scopus 로고    scopus 로고
    • 2+ and mitochondrial biogenesis
    • COI: 1:CAS:528:DC%2BC2cXhslyqur%2FI, PID: 25196599
    • 2+ and mitochondrial biogenesis. Int J Mol Sci 15(8):14591–14609
    • (2014) Int J Mol Sci , vol.15 , Issue.8 , pp. 14591-14609
    • Dai, S.H.1    Chen, T.2    Wang, Y.H.3
  • 31
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXitVGlt7k%3D, PID: 18218341
    • Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer’s disease. Trends Mol Med 14(2):45–53
    • (2008) Trends Mol Med , vol.14 , Issue.2 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 32
    • 84876445381 scopus 로고    scopus 로고
    • CNS sirt3 expression is altered by reactive oxygen species and in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38Xhslamu7fJ, PID: 23139766
    • Weir HJ, Murray TK, Kehoe PG et al (2012) CNS sirt3 expression is altered by reactive oxygen species and in Alzheimer’s disease. PLoS One 7(11):e48225
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e48225
    • Weir, H.J.1    Murray, T.K.2    Kehoe, P.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.