D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

Neuropsychopharmacology

Volumn 40, Issue 10, 2015, Pages 2357-2367

  Seif, Taban ^a   Simms, Jeffrey A ^a   Lei, Kelly ^a   Wegner, Scott ^a   Bonci, Antonello ^b,c   Messing, Robert O ^a,d   Hopf, F Woodward ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSERINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUININE; SACCHARIN; SERINE; 2-AMINO-5-PHOSPHOPENTANOIC ACID; ALCOHOL; AMINO ACID RECEPTOR BLOCKING AGENT; VALINE;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVERSION; DIFFUSION; DORSOLATERAL STRIATUM; FLUID INTAKE; HISTOLOGY; IN VITRO STUDY; MEMBRANE STEADY POTENTIAL; NONHUMAN; NUCLEUS ACCUMBENS CORE; PRIORITY JOURNAL; RAT; ANALOGS AND DERIVATIVES; ANIMAL; COMPULSIVE BEHAVIOR; CYTOLOGY; DRINKING BEHAVIOR; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MALE; METABOLISM; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; WISTAR RAT;

ALCOHOL DRINKING; ANIMALS; COMPULSIVE BEHAVIOR; CYCLOSERINE; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; IN VITRO TECHNIQUES; MALE; PREFRONTAL CORTEX; RATS; RATS, WISTAR; SACCHARIN; SERINE; VALINE;

EID: 84939259010     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.84     Document Type: Article

References (60)

1. Anton RF (2000). Obsessive-compulsive aspects of craving: development of the Obsessive Compulsive Drinking Scale. Addiction 95(Suppl 2): S211-S217.
2. Bisaga A, Evans SM (2004). Acute effects of memantine in combination with alcohol in moderate drinkers. Psychopharmacology 172: 16-24.
3. Carnicella S, Amamoto R, Ron D (2009). Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol 43: 35-43.
4. Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y et al (2002). Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 415: 793-798.
5. Ciriacks CM, Bowser MT (2006). Measuring the effect of glutamate receptor agonists on extracellular D-serine concentrations in the rat striatum using online microdialysis-capillary electrophoresis. Neurosci Lett 393: 200-205.
6. Cull-Candy SG, Leszkiewicz DN (2004). Role of distinct NMDA receptor subtypes at central synapses. Sci STKE 2004: re16.
7. Curcio L, Podda MV, Leone L, Piacentini R, Mastrodonato A, Cappelletti P et al (2013). Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity. Brain 136: 1216-1230.
8. Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE et al (1998). Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393: 377-381.
9. Debrouse L, Hurd B, Kiselycznyk C, Plitt A, Todaro A, Mishina M et al (2013). Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine coagonist site. Alcohol Clin Exp Res 37: 223-233.
10. Deroche-Gamonet V, Piazza PV (2014). Psychobiology of cocaine addiction: contribution of a multi-symptomatic animal model of loss of control. Neuropharmacology 76: 437-449.
11. D'Ascenzo M, Podda MV, Grassi C (2014). The role of D-serine as co-agonist of NMDA receptors in the nucleus accumbens: relevance to cocaine addiction. Front Synaptic Neurosci 6: 16-21.
12. D'Souza DC, Radhakrishnan R, Perry E, Bhakta S, Singh NM, Yadav R et al (2013). Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study. Neuropsychopharmacology 38: 492-503.
13. Evans SM, Levin FR, Brooks DJ, Garawi F (2007). A pilot doubleblind treatment trial of memantine for alcohol dependence. Alcohol Clin Exp Res 31: 775-782.
14. Everitt BJ, Robbins TW (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: 1481-1489.
15. Fiorenza NG, Rosa J, Izquierdo I, Myskiw JC (2012). Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas. Behav Brain Res 232: 210-216.
16. Gass JT, Olive MF (2008). Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75: 218-265.
17. Gerfen CR (2004). Basal ganglia. In: Paxinos G (ed) The Rat Brain, Elsevier: New York, pp 455-508.
18. Goodwin FL, Bergeron N, Amit Z (2000). Differences in the consumption of alcohol and flavored solutions in three strains of rats. Pharmacol Biochem Behav 65: 357-362.
19. Hashimoto A, Chiba S (2004). Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat. Eur J Pharmacol 495: 153-158.
20. Henderson G, Johnson JW, Ascher P (1990). Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor. J Physiol 430: 189-212.
21. Heresco-Levy U, Shoham S, Javitt DC (2013). Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis. Mov Disord 28: 419-424.
22. Hopf FW, Chang SJ, Sparta DR, Bowers MS, Bonci A (2010). Motivation for alcohol becomes resistant to quinine adulteration after 3-4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res 34: 1565-1573.
23. Hopf FW, Lesscher HM (2014). Rodent models for compulsive alcohol intake. Alcohol 48: 253-264.
24. Junjaud G, Rouaud E, Turpin F, Mothet JP, Billard JM (2006). Agerelated effects of the neuromodulator D-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat. J Neurochem 98: 1159-1166.
25. Kantrowitz JT, Malhotra AK, Cornblatt B, Silipo G, Balla A, Suckow RF et al (2010). High dose D-serine in the treatment of schizophrenia. Schizophr Res 121: 125-130.
26. Koob GF, Volkow ND (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.
27. Kretschmer BD, Schmidt WJ (1996). Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens. J Neurosci 16: 1561-1569.
28. Krug AW, Völker K, Dantzler WH, Silbernagl S (2007). Why is D-serine nephrotoxic and alpha-aminoisobutyric acid protective? Am J Physiol Renal Physiol 293: F382-F390.
29. Krupitsky EM, Neznanova O, Masalov D, Burakov AM, Didenko T, Romanova T et al (2007). Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients. Am J Psychiatry 164: 519-523.
30. Krystal JH, Petrakis IL, Limoncelli D, Nappi SK, Trevisan L, Pittman B et al (2011). Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence. Neuropsychopharmacology 36: 701-710.
31. Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC (2003). N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther 99: 79-94.
32. Lesscher HM, van Kerkhof LW, Vanderschuren LJ (2010). Inflexible and indifferent alcohol drinking in male mice. Alcohol Clin Exp Res 34: 1219-1225.
33. Lockridge A, Romero G, Harrington J, Newland B, Gong Z, Cameron A et al (2012). Timing-dependent reduction in ethanol sedation and drinking preference by NMDA receptor co-agonist D-serine. Alcohol 6: 389-400.
34. Martineau M, Parpura V, Mothet JP (2014). Cell-type specific mechanisms of D-serine uptake and release in the brain. Front Synaptic Neurosci 6: 12.
35. Matsui T, Sekiguchi M, Hashimoto A, Tomita U, Nishikawa T, Wada K (1995). Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem 65: 454-458.
36. Millan MJ (2005). N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives. Psychopharmacology 179: 30-53.
37. Modell JG, Glaser FB, Mountz JM, Schmaltz S, Cyr L (1992). Obsessive and compulsive characteristics of alcohol abuse and dependence: quantification by a newly developed questionnaire. Alcohol Clin Exp Res 16: 266-271.
38. Moraes Ferreira VM, Morato GS (1997). D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plusmaze. Alcohol Clin Exp Res 21: 1638-1642.
39. Muhonen LH, Lonnqvist J, Juva K, Alho H (2008). Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence. J Clin Psychiatry 69: 392-399.
40. Naqvi NH, Gaznick N, Tranel D, Bechara A (2014). The insula: a critical neural substrate for craving and drug seeking under conflict and risk. Ann NY Acad Sci 1316: 53-70.
41. Nishikawa T (2011). Analysis of free D-serine in mammals and its biological relevance. J Chromatogr B Analyt Technol Biomed Life Sci 879: 3169-3183.
42. Roitman MF, Wheeler RA, Carelli RM (2005). Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output. Neuron 45: 587-597.
43. Rouaud E, Billard JM (2003). D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol 140: 1051-1056.
44. Sani G, Serra G, Kotzalidis GD, Romano S, Tamorri SM, Manfredi G et al (2012). The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence. CNS Drugs 26: 663-690.
45. Schwienbacher I, Fendt M, Richardson R, Schnitzler HU (2004). Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats. Brain Res 1027: 87-93.
46. Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT et al (2013). Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci 16: 1094-1100.
47. Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R, Bartlett SE (2008). Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 32: 1816-1823.
48. Smothers CT, Woodward JJ (2007). Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. J Pharmacol Exp Ther 322: 739-748.
49. Spanagel R (2009). Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89: 649-705.
50. Spanagel R, Vengeliene V, Jandeleit B, Fischer WN, Grindstaff K, Zhang X, Gallop MA, Krstew EV, Lawrence AJ, Kiefer F (2014). Acamprosate produces its anti-relapse effects via calcium. Neuropsychopharmacology 39: 783-791.
51. Takarada T, Takahata Y, Iemata M, Hinoi E, Uno K, Hirai T et al (2009). Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes. J Cell Physiol 220: 756-764.
52. Takarada T, Takarada-Iemata M, Takahata Y, Yamada D, Yamamoto T, Nakamura Y et al (2012). Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts. J Cell Physiol 227: 3477-3487.
53. Tiffany ST, Conklin CA (2000). A cognitive processing model of alcohol craving and compulsive alcohol use. Addiction 95(Suppl 2): S145-S153.
54. Torregrossa MM, Sanchez H, Taylor JR (2010). D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens. J Neurosci 30: 10526-10533.
55. Tsai GE, Lin PY (2010). Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis. Curr Pharm Des 16: 522-537.
56. Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R (2009). Compulsive alcohol drinking in rodents. Addict Biol 14: 384-396.
57. Wolffgramm J, Galli G, Thimm F, Heyne A (2000). Animal models of addiction: models for therapeutic strategies? J Neural Transm 107: 649-668.
58. Wu HQ, Schwarcz R, Shepard PD (1994). Excitatory amino acidinduced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid. Synapse 16: 219-230.
59. Yaka R, Biegon A, Grigoriadis N, Simeonidou C, Grigoriadis S, Alexandrovich AG et al (2007). D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J 21: 2033-2041.
60. Zhang Z, Gong N, Wang W, Xu L, Xu TL (2008). Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval. Cereb Cortex 18: 2391-2401.