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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3329-3332

Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.

(9) Khokhar, Shahan a Feng, Yunjiang a Campitelli, Marc R a Ekins, Merrick G b Hooper, John N A a,b Beattie, Karren D a Sadowski, Martin C c Nelson, Colleen C c Davis, Rohan A a

a GRIFFITH UNIVERSITY (Australia)

b QUEENSLAND MUSEUM (Australia)

c Translational Research Institute (Australia)

Author keywords

Cytotoxicity; DFT NMR; Hyrtios; Marine sponge; Tryptophan alkaloid

Indexed keywords

6 OXOFASCAPLYSIN; ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; FASCAPLYSIN; RETICULATATE; SECOFASCAPLYSIC ACID; TRYPTOPHAN ALKALOID; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; ALKALOID; TRYPTOPHAN; ANTINEOPLASTIC ALKALOID; DOXORUBICIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYRTIOS; IC 50; MARINE SPECIES; MASS SPECTROMETRY; PROSTATE CANCER CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; AUSTRALIA; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ISOLATION AND PURIFICATION; QUANTUM THEORY; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; ANTINEOPLASTIC ACTIVITY; CONTROLLED STUDY; DRUG SELECTIVITY; IC50; LNCAP CELL LINE; MALE; NEWBORN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

HYRTIOS;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; AUSTRALIA; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PORIFERA; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 84904042943 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.05.104 Document Type: Article

Times cited : (27)

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