Effects of the DGAT1 polymorphism on test-day milk production traits throughout lactation

Journal of Dairy Science

Volumn 98, Issue 9, 2015, Pages 6572-6582

  Bovenhuis, H ^a   Visker, M H P W ^a   van Valenberg, H J F ^a   Buitenhuis, A J ^b   van Arendonk, J A M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

DGAT1; Energy output; Lactation stage; Lactose

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE; FAT INTAKE; LACTOSE; PROTEIN INTAKE;

ANALYSIS; ANIMAL; BOVINE; FAT INTAKE; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; LACTATION; METABOLISM; MILK; PHENOTYPE; PROTEIN INTAKE; SECRETION (PROCESS);

ANIMALS; CATTLE; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY FATS; DIETARY PROTEINS; FEMALE; GENOTYPE; LACTATION; LACTOSE; MILK; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 84939251644     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2015-9564     Document Type: Article

References (37)

1. Banos G., Woolliams J.A., Woodward B.W., Forbes A.B., Coffey M.P. Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. J. Dairy Sci. 2008, 91:3190-3200.
2. Barbosa da Silva M.V.G., Sonstegard T.S., Thallman R.M., Connor E.E., Schnabel R.D., Van Tassell C.P. Characterization of DGAT1 allelic effects in a sample of North American Holstein cattle. Anim. Biotechnol. 2010, 21:88-99.
3. Berry D.P., Howard D., O'Boyle P., Waters S., Kearney J.F., McCabe M. Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle. Ir. J. Agric. Food Res. 2010, 49:1-9.
4. Bionaz M., Loor J.J. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 2008, 9:366. http://dx.doi.org/10.1186/1471-2164-9-366.
5. Bionaz M., Periasamy K., Rodriguez-Zas S.L., Hurley W.L., Loor J.J. A novel dynamic impact approach (DIA) for functional analysis of time-course omics studies: Validation using the bovine mammary transcriptome. PLoS ONE 2012, 7:e32455. http://dx.doi.org/10.1371/journal.pone.0032455.
6. Caccamo M., Veerkamp R.F., de Jong G., Pool M.H., Petriglieri R., Licitra G. Variance components for test-day milk, fat, and protein yield, and somatic cell score for analyzing management information. J. Dairy Sci. 2008, 91:3268-3276.
7. Cases S., Stone S.J., Zhou P., Yen E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J. Biol. Chem. 2001, 276:38870-38876.
8. Demeter R.M., Schopen G.C.B., Oude Lansink A.G.J.M., Meuwissen M.P.M., van Arendonk J.A.M. Effects of milk fat composition, DGAT1, and SCD1 on fertility traits in Dutch Holstein cattle. J. Dairy Sci. 2009, 92:5720-5729.
9. DeVita R.J., Pinto S. Current status of the research and development of diacylglycerol o-acyltransferase 1 (DGAT1) inhibitors. J. Med. Chem. 2013, 56:9820-9825.
10. Druet T., Jaffrézic F., Boichard D., Ducrocq V. Modeling lactation curves and estimation of genetic parameters for first lactation test-day records of French Holstein cows. J. Dairy Sci. 2003, 86:2480-2490.
11. Duchemin S., Bovenhuis H., Stoop W.M., Bouwman A.C., van Arendonk J.A.M., Visker M.H.P.W. Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions. J. Dairy Sci. 2013, 96:592-604.
12. Fox P. Lactose: Chemistry and properties. Advanced Dairy Chemistry, Volume 3: Lactose, Water, Salts and Minor Constituents 2009, 1-15. Springer Science+Business Media LLC, New York, NY, http://dx.doi.org/10.1007/978-0-387-84865-5_1. P.L.H. McSweeney, P.F. Fox (Eds.).
13. Gao Y., Lin X., Shi K., Yan Z., Wang Z. Bovine mammary gene expression profiling during the onset of lactation. PLoS ONE 2013, 8:e70393. http://dx.doi.org/10.1371/journal.pone.0070393.
14. Garnsworthy P.C., Masson L.L., Lock A.L., Mottram T.T. Variation of milk citrate with stage of lactation and de novo fatty acid synthesis in dairy cows. J. Dairy Sci. 2006, 89:1604-1612.
15. Gautier M., Capitan A., Fritz S., Eggen A., Boichard D., Druet T. Characterization of the DGAT1 K232A and variable number of tandem repeat polymorphisms in French dairy cattle. J. Dairy Sci. 2007, 90:2980-2988.
16. Gilmour, A. R., B. Gogel, B. Cullis, and R. Thompson. 2009. ASReml user guide release 3.0. VSN International Ltd., Hemel Hempstead, UK.
17. Grisart B., Coppieters W., Farnir F., Karim L., Ford C., Berzi P., Cambisano N., Mni M., Reid S., Simon P., Spelman R., Georges M., Snell R. Positional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res. 2002, 12:222-231.
18. Grisart B., Farnir F., Karim L., Cambisano N., Kim J.J., Kvasz A., Mni M., Simon P., Frere J.M., Coppieters W., Georges M. Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc. Natl. Acad. Sci. USA 2004, 101:2398-2403.
19. Kaupe B., Brandt H., Prinzenberg E.M., Erhardt G. Joint analysis of the influence of CYP11B1 and DGAT1 genetic variation on milk production, somatic cell score, conformation, reproduction and productive lifespan in German Holstein cattle. J. Anim. Sci. 2007, 85:11-21.
20. Kuehn C., Edel C., Weikard R., Thaller G. Dominance and parent-of-origin effects of coding and non-coding alleles at the acylCoA-diacylglycerol-acyltransferase (DGAT1) gene on milk production traits in German Holstein cows. BMC Genet. 2007, 8:62. http://dx.doi.org/10.1186/1471-2156-8-62.
21. Lund M.S., Sorensen P., Madsen P., Jaffrezic F. Detection and modelling of time-dependent QTL in animal populations. Genet. Sel. Evol. 2008, 40:177-194.
22. Mach N., Blum Y., Bannink A., Causeur D., Houee-Bigot M., Lagarrigue S., Smits M.A. Pleiotropic effects of polymorphism of the gene diacylglycerol-Otransferase 1 (DGAT1) in the mammary gland tissue of dairy cows. J. Dairy Sci. 2012, 95:4989-5000.
23. Muise E.S., Zhu Y., Verras A., Karanam B.V., Gorski J., Weingarth D., Lin H.V., Hwa J., Thompson J.R., Hu G., Liu J., He S., DeVita R.J., Shen D.M., Pinto S. Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors. PLoS ONE 2014, 9:e88908.
24. Oikonomou G., Angelopoulou K., Arsenos G., Zygoyiannis D., Banos G. The effects of polymorphisms in the DGAT1, leptin and growth hormone receptor gene loci on body energy, blood metabolic and reproductive traits of Holstein cows. Anim. Genet. 2009, 40:10-17.
25. Schennink A., Heck J.M.L., Bovenhuis H., Visker M.H.P.W., van Valenberg H.J.F., van Arendonk J.A.M. Milk fatty acid unsaturation: Genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and Acyl CoA: Diacylglycerol acyltransferase (DGAT1). J. Dairy Sci. 2008, 91:2135-2143.
26. Schennink A., Stoop W.M., Visker M.H.P.W., Heck J.M.L., Bovenhuis H., van der Poel J.J., van Valenberg H.J.F., van Arendonk J.A.M. DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Anim. Genet. 2007, 38:467-473.
27. Spelman R.J., Ford C.A., McElhinney P., Gregory G.C., Snell R.G. Characterization of the DGAT1 gene in the New Zealand dairy population. J. Dairy Sci. 2002, 85:3514-3517.
28. Stoop W.M., Bovenhuis H., van Arendonk J.A.M. Genetic parameters for milk urea nitrogen in relation to milk production traits. J. Dairy Sci. 2007, 90:1981-1986.
29. Stoop W.M., van Arendonk J.A.M., Heck J.M.L., van Valenberg H.J.F., Bovenhuis H. Genetic parameters for milk fatty acids and milk production traits of Dutch Holstein Friesians. J. Dairy Sci. 2008, 91:385-394.
30. Strucken E.M., de Koning D.J., Rahmatalla S.A., Brockmann G.A. Lactation curve models for estimating gene effects over a timeline. J. Dairy Sci. 2011, 94:442-449.
31. Szyda J., Komisarek J., Antkowiak I. Modelling effects of candidate genes on complex traits as variables over time. Anim. Genet. 2014, 45:322-328.
32. Thaller G., Krämer W., Winter A., Kaupe B., Erhardt G., Fries R. Effects of DGAT1 variants on milk production traits in German cattle breeds. J. Anim. Sci. 2003, 81:1911-1918.
33. Tyrrell H.F., Reid J.T. Prediction of the energy value of cow's milk. J. Dairy Sci. 1965, 48:1215-1223.
34. Weller J.I., Golik M., Seroussi E., Ezra E., Ron M. Population-wide analysis of a QTL affecting milk-fat production in the Israeli Holstein population. J. Dairy Sci. 2003, 86:2219-2227.
35. Wickramasinghe S., Rincon G., Islas-Trejo A., Medrano J.F. Transcriptional profiling of bovine milk using RNA sequencing. BMC Genomics 2012, 13:45.
36. Winter A., Kramer W., Werner F.A., Kollers S., Kata S., Durstewitz G., Buitkamp J., Womack J.E., Thaller G., Fries R. Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proc. Natl. Acad. Sci. USA 2002, 99:9300-9305.
37. Wright S. Physiological and evolutionary theories of dominance. Am. Nat. 1934, 68:24-53.