Pleiotropic effects of polymorphism of the gene diacylglycerol-O-transferase 1 (DGAT1) in the mammary gland tissue of dairy cows

Journal of Dairy Science

Volumn 95, Issue 9, 2012, Pages 4989-5000

  Mach, N ^a,c   Blum, Y ^b   Bannink, A ^a   Causeur, D ^b   Houee Bigot, M ^b   Lagarrigue, S ^b   Smits, M A ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b AGROCAMPUS OUEST   (France)

^c UMR1313 GÉNÉTIQUE ANIMALE ET BIOLOGIE INTÉGRATIVE   (France)

Author keywords

Diacylglycerol O transferase 1 (DGAT1) gene; Lactating cow; Mammary gland; Microarray

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE;

AMINO ACID SUBSTITUTION; ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; DNA MICROARRAY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPING TECHNIQUE; HETEROZYGOTE; HOMOZYGOTE; LACTATION; METABOLISM; PHYSIOLOGY; PLEIOTROPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UDDER;

AMINO ACID SUBSTITUTION; ANIMALS; CATTLE; DIACYLGLYCEROL O-ACYLTRANSFERASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC PLEIOTROPY; GENOTYPING TECHNIQUES; HETEROZYGOTE; HOMOZYGOTE; LACTATION; MAMMARY GLANDS, ANIMAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84865309881     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2012-5348     Document Type: Article

References (29)

1. Banos G., Woolliams J.A., Woodward B.W., Forbes A.B., Coffey M.P. Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. J. Dairy Sci. 2008, 91:3190-3200.
2. Berry D.P., Howard D., O'Boyle S., Waters S., Kearney J.F., McCabe M. Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle. Ir. J. Agric. Food Res. 2010, 49:1-9.
3. Bionaz M., Thering B.J., Loor J.J. Fine metabolic regulation in ruminants via nutrient-gene interactions: Saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation. Br. J. Nutr. 2012, 107:179-191.
4. Blum Y., Le Mignon G., Lagarrigue S., Causeur D. A factor model to analyze heterogeneity in gene expression. BMC Bioinformatics 2010, 11:368.
5. Boichard D., Grohs C., Bourgeois F., Cerqueira F., Faugeras R., Neau A., Rupp R., Amigues Y., Boscher M., Levéziel H. Detection of genes influencing economic traits in three French dairy cattle breeds. Genet. Sel. Evol. 2003, 35:77-101.
6. Bouwman A.C., Bovenhuis H., Visker M.H., van Arendonk J.A. Genome-wide association of milk fatty acids in Dutch dairy cattle. BMC Genet. 2011, 12:43-55.
7. Bünger M., van den Bosch H.M., van der Meijde J., Kersten S., Hooiveld G.J.E.J., Müller M. Genome-wide analysis of PPARα activation in murine small intestine. Physiol. Genomics 2007, 30:192-204.
8. Caesar R., Manieri M., Kelder T., Boekschoten M., Evelo C., Müller M., Kooistra T., Cinti S., Kleemann R., Drevon C.A. A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences. PLoS ONE 2010, 5:e11525. http://dx.doi.org/10.1371/journal.pone.0011525.
9. Causeur D., Friguet C., Houee-Bigot M., Kloareg M. Factor analysis for multiple testing (FAMT): An R package for large-scale significance testing under dependence. J. Stat. Softw. 2011, 40:1-19.
10. Connor E.E., Siferd S., Elsasser T.H., Evock-Clover C.M., Van Tassell C.P., Sonstegard T.S., Fernandes V.M., Capuco A.V. Effects of increased milking frequency on gene expression in the bovine mammary gland. BMC Genomics 2008, 9:362.
11. Contreras G.A., Sordillo L.M. Lipid mobilization and inflammatory responses during the transition period of dairy cows. Comp. Immunol. Microbiol. Infect. Dis. 2011, 34:281-289.
12. Danchin-Burge C., Hiemstra S.J., Blackburn H. Ex situ conservation of Holstein-Friesian cattle: Comparing the Dutch, French, and US germplasm collections. J. Dairy Sci. 2011, 94:4100-4108.
13. Donaldson L., Vuocolo T., Gray C., Strandberg Y., Reverter A., McWilliam S., Wang Y., Byrne K., Tellam R. Construction and validation of a bovine innate immune microarray. BMC Genomics 2005, 6:135.
14. Farr V.C., Stelwagen K., Cate L.R., Molenaar A.J., McFadden T.B., Davis S.R. An improved method for the routine biopsy of bovine mammary tissue. J. Dairy Sci. 1996, 79:543-549.
15. Friguet C., Kloareg M., Causeur D. A factor model approach to multiple testing under dependence. J. Am. Stat. Assoc. 2009, 104:1406-1415.
16. Gautier M., Capitan A., Fritz S., Eggen A., Boichard D., Druet T. Characterization of the DGAT1 K232A and variable number of tandem repeat polymorphisms in French dairy cattle. J. Dairy Sci. 2007, 90:2980-2988.
17. Grisart B., Farnir F., Karim L., Cambisano N., Kim J.J., Kvasz A., Mni M., Simon P., Frere J.M., Coppieters W., Georges M. Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc. Natl. Acad. Sci. USA 2004, 101:2398-2403.
18. Koliwad S.K., Streeper R.S., Monetti M., Cornelissen I., Chan L., Terayama K., Naylor S., Rao M., Hubbard B., Farese R.V. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J. Clin. Invest. 2010, 120:756-767.
19. Lê S., Josse J., Husson F. FactoMineR: An R package for multivariate analysis. J. Stat. Softw. 2008, 25:1-18.
20. Loor J.J., Husson H.M., Dann R.E., Everts R., Oliveira C.A., Green N.A., Guretzky S.L., Rodriguez-Zas H.A., Lewin J.K. Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function. Physiol. Genomics 2005, 23:217-226.
21. Loor J.J., Drackley H.M., Dann N.A., Guretzky R.E., Everts R., Oliveira C.A., Green N.B., Litherland S.L., Rodriguez-Zas H.A., Lewin J.K. Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol. Genomics 2006, 27:29-41.
22. Mach N., Drackley A.A.A., Jacobs L., Kruijt J., Smits M.A. Alteration of gene expression in mammary gland tissue of dairy cows in response to dietary unsaturated fatty acids. Animal 2011, 5:1217-1230.
23. van Baal C.R., McCudden M.D., Hains R.J., Kimple D.P., Siderovski F.S. G-protein signaling: Back to the future. Cell. Mol. Life Sci. 2005, 62:551-577.
24. Willard T.L., Odong J., van Heerwaarden J.H., Jansen T.J.L., van Hintum F.A. Determination of genetic structure of germplasm collections: Are traditional hierarchical clustering methods appropriate for molecular marker data?. Theor. Appl. Genet. 2011, 123:195-205.
25. van Eeuwijk J., Ogorevc T., Kunej A., Razpet P. Database of cattle candidate genes and genetic markers for milk production and mastitis. Anim. Genet. 2009, 40:832-851.
26. Dovc A., Schennink J.M.L., Bovenhuis H., Heck M.H.P.W., Visker H.J.F., van Valenberg J.A.M. Milk fatty acid unsaturation: Genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1). J. Dairy Sci. 2008, 91:2135-2143.
27. van Arendonk A., Schennink W.M., Stoop M.H.P.W., Visker J.M.L., Bovenhuis H., Heck J.J., van der Poel H.J.F., van Valenberg J.A.M. DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Anim. Genet. 2007, 38:467-473.
28. van Arendonk A., Subramanian P., Tamayo V.K., Mootha S., Mukherjee B.L., Ebert M.A., Gillette A., Paulovich S.L., Pomeroy T.R., Golub E.S., Lander J.P. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 2005, 102:15545-15550.
29. Thaller G., Kramer W., Winter A., Kaupe B., Erhardt G., Fries R. Effects of DGAT1 variants on milk production traits in German cattle breeds. J. Anim. Sci. 2003, 81:1911-1918.