메뉴 건너뛰기




Volumn 1, Issue 5, 2015, Pages 550-569

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice

Author keywords

Npr3; Pancreatic Ducts; Primary Cilia

Indexed keywords

CRE RECOMBINASE; G PROTEIN COUPLED RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 6; MESSENGER RNA; NATRIURETIC PEPTIDE RECEPTOR 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HHEX; UNCLASSIFIED DRUG;

EID: 84939225918     PISSN: None     EISSN: 2352345X     Source Type: Journal    
DOI: 10.1016/j.jcmgh.2015.06.007     Document Type: Article
Times cited : (10)

References (75)
  • 1
    • 0015896349 scopus 로고
    • Pancreatic acinar cells: acetylcholine-induced membrane depolarization, calcium efflux and amylase release
    • Matthews E.K., Petersen O.H., Williams J.A. Pancreatic acinar cells: acetylcholine-induced membrane depolarization, calcium efflux and amylase release. JPhysiol 1973, 234:689-701.
    • (1973) JPhysiol , vol.234 , pp. 689-701
    • Matthews, E.K.1    Petersen, O.H.2    Williams, J.A.3
  • 2
    • 0016837538 scopus 로고
    • Pancreatic acinar cells: effect of acetylcholine, pancreozymin, gastrin and secretin on membrane potential and resistance invivo and invitro
    • Petersen O.H., Ueda N. Pancreatic acinar cells: effect of acetylcholine, pancreozymin, gastrin and secretin on membrane potential and resistance invivo and invitro. JPhysiol 1975, 247:461-471.
    • (1975) JPhysiol , vol.247 , pp. 461-471
    • Petersen, O.H.1    Ueda, N.2
  • 3
    • 84055193971 scopus 로고    scopus 로고
    • Pancreatic ductal cells in development, regeneration, and neoplasia
    • Reichert M., Rustgi A.K. Pancreatic ductal cells in development, regeneration, and neoplasia. JClin Invest 2011, 121:4572-4578.
    • (2011) JClin Invest , vol.121 , pp. 4572-4578
    • Reichert, M.1    Rustgi, A.K.2
  • 4
    • 16644371666 scopus 로고    scopus 로고
    • Amathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice
    • Whitcomb D.C., Ermentrout G.B. Amathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice. Pancreas 2004, 29:e30-e40.
    • (2004) Pancreas , vol.29 , pp. e30-e40
    • Whitcomb, D.C.1    Ermentrout, G.B.2
  • 5
    • 0018902922 scopus 로고
    • Effects of gastrointestinal hormones and carbamylcholine on cAMP accumulation in isolated pancreatic duct fragments from the rat
    • Folsch U.R., Fischer H., Soling H.D., et al. Effects of gastrointestinal hormones and carbamylcholine on cAMP accumulation in isolated pancreatic duct fragments from the rat. Digestion 1980, 20:277-292.
    • (1980) Digestion , vol.20 , pp. 277-292
    • Folsch, U.R.1    Fischer, H.2    Soling, H.D.3
  • 6
    • 0027526366 scopus 로고
    • CAMP-regulated whole cell chloride currents in pancreatic duct cells
    • Gray M.A., Plant S., Argent B.E. cAMP-regulated whole cell chloride currents in pancreatic duct cells. Am J Physiol 1993, 264:C591-C602.
    • (1993) Am J Physiol , vol.264 , pp. C591-C602
    • Gray, M.A.1    Plant, S.2    Argent, B.E.3
  • 7
    • 0025181976 scopus 로고
    • Effect of vasoactive intestinal peptide, bombesin and substance P on fluid secretion by isolated rat pancreatic ducts
    • Ashton N., Argent B.E., Green R. Effect of vasoactive intestinal peptide, bombesin and substance P on fluid secretion by isolated rat pancreatic ducts. JPhysiol 1990, 427:471-482.
    • (1990) JPhysiol , vol.427 , pp. 471-482
    • Ashton, N.1    Argent, B.E.2    Green, R.3
  • 8
    • 0025805816 scopus 로고
    • Characteristics of fluid secretion from isolated rat pancreatic ducts stimulated with secretin and bombesin
    • Ashton N., Argent B.E., Green R. Characteristics of fluid secretion from isolated rat pancreatic ducts stimulated with secretin and bombesin. JPhysiol 1991, 435:533-546.
    • (1991) JPhysiol , vol.435 , pp. 533-546
    • Ashton, N.1    Argent, B.E.2    Green, R.3
  • 9
    • 0027420837 scopus 로고
    • Regulation of fluid secretion and intracellular messengers in isolated rat pancreatic ducts by acetylcholine
    • Ashton N., Evans R.L., Elliott A.C., et al. Regulation of fluid secretion and intracellular messengers in isolated rat pancreatic ducts by acetylcholine. JPhysiol 1993, 471:549-562.
    • (1993) JPhysiol , vol.471 , pp. 549-562
    • Ashton, N.1    Evans, R.L.2    Elliott, A.C.3
  • 11
    • 77954754938 scopus 로고    scopus 로고
    • ATP storage and uptake by isolated pancreatic zymogen granules
    • Haanes K.A., Novak I. ATP storage and uptake by isolated pancreatic zymogen granules. Biochem J 2010, 429:303-311.
    • (2010) Biochem J , vol.429 , pp. 303-311
    • Haanes, K.A.1    Novak, I.2
  • 12
    • 0027730475 scopus 로고
    • Regulated secretory proteins in the exocrine pancreas aggregate under conditions that mimic the trans-Golgi network
    • Freedman S.D., Scheele G.A. Regulated secretory proteins in the exocrine pancreas aggregate under conditions that mimic the trans-Golgi network. Biochem Biophys Res Commun 1993, 197:992-999.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 992-999
    • Freedman, S.D.1    Scheele, G.A.2
  • 13
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
    • Riordan J.R., Rommens J.M., Kerem B., et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 1989, 245:1066-1073.
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riordan, J.R.1    Rommens, J.M.2    Kerem, B.3
  • 14
    • 0023719216 scopus 로고
    • Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas
    • Kopelman H., Corey M., Gaskin K., et al. Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. Gastroenterology 1988, 95:349-355.
    • (1988) Gastroenterology , vol.95 , pp. 349-355
    • Kopelman, H.1    Corey, M.2    Gaskin, K.3
  • 15
  • 16
    • 0026462854 scopus 로고
    • Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells
    • Crompton M.R., Bartlett T.J., MacGregor A.D., et al. Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucleic Acids Res 1992, 20:5661-5667.
    • (1992) Nucleic Acids Res , vol.20 , pp. 5661-5667
    • Crompton, M.R.1    Bartlett, T.J.2    MacGregor, A.D.3
  • 17
    • 84898914052 scopus 로고    scopus 로고
    • The diabetes gene Hhex maintains delta-cell differentiation and islet function
    • Zhang J., McKenna L.B., Bogue C.W., et al. The diabetes gene Hhex maintains delta-cell differentiation and islet function. Genes Dev 2014, 28:829-834.
    • (2014) Genes Dev , vol.28 , pp. 829-834
    • Zhang, J.1    McKenna, L.B.2    Bogue, C.W.3
  • 18
    • 0141816708 scopus 로고    scopus 로고
    • The homeoprotein Hex is required for hemangioblast differentiation
    • Guo Y., Chan R., Ramsey H., et al. The homeoprotein Hex is required for hemangioblast differentiation. Blood 2003, 102:2428-2435.
    • (2003) Blood , vol.102 , pp. 2428-2435
    • Guo, Y.1    Chan, R.2    Ramsey, H.3
  • 19
    • 8444234265 scopus 로고    scopus 로고
    • Anull mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels
    • Hallaq H., Pinter E., Enciso J., et al. Anull mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Development 2004, 131:5197-5209.
    • (2004) Development , vol.131 , pp. 5197-5209
    • Hallaq, H.1    Pinter, E.2    Enciso, J.3
  • 20
    • 0034124779 scopus 로고    scopus 로고
    • The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
    • Martinez Barbera J.P., Clements M., Thomas P., et al. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development 2000, 127:2433-2445.
    • (2000) Development , vol.127 , pp. 2433-2445
    • Martinez Barbera, J.P.1    Clements, M.2    Thomas, P.3
  • 21
    • 0032540439 scopus 로고    scopus 로고
    • Expression of Hex mRNA in early murine postimplantation embryo development
    • Keng V.W., Fujimori K.E., Myint Z., et al. Expression of Hex mRNA in early murine postimplantation embryo development. FEBS Lett 1998, 426:183-186.
    • (1998) FEBS Lett , vol.426 , pp. 183-186
    • Keng, V.W.1    Fujimori, K.E.2    Myint, Z.3
  • 22
    • 0031984524 scopus 로고    scopus 로고
    • Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
    • Thomas P.Q., Brown A., Beddington R.S. Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 1998, 125:85-94.
    • (1998) Development , vol.125 , pp. 85-94
    • Thomas, P.Q.1    Brown, A.2    Beddington, R.S.3
  • 23
    • 0033843244 scopus 로고    scopus 로고
    • Hex expression suggests a role in the development and function of organs derived from foregut endoderm
    • Bogue C.W., Ganea G.R., Sturm E., et al. Hex expression suggests a role in the development and function of organs derived from foregut endoderm. Dev Dyn 2000, 219:84-89.
    • (2000) Dev Dyn , vol.219 , pp. 84-89
    • Bogue, C.W.1    Ganea, G.R.2    Sturm, E.3
  • 24
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort R., Martinez-Barbera J.P., Beddington R.S., et al. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004, 131:797-806.
    • (2004) Development , vol.131 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3
  • 25
    • 30544442260 scopus 로고    scopus 로고
    • Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development
    • Bort R., Signore M., Tremblay K., et al. Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol 2006, 290:44-56.
    • (2006) Dev Biol , vol.290 , pp. 44-56
    • Bort, R.1    Signore, M.2    Tremblay, K.3
  • 27
    • 0142244134 scopus 로고    scopus 로고
    • Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors
    • Sabbatini M.E., Villagra A., Davio C.A., et al. Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors. Am J Physiol Gastrointest Liver Physiol 2003, 285:G929-G937.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , pp. G929-G937
    • Sabbatini, M.E.1    Villagra, A.2    Davio, C.A.3
  • 28
    • 34547667392 scopus 로고    scopus 로고
    • The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis
    • Hunter M.P., Wilson C.M., Jiang X., et al. The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol 2007, 308:355-367.
    • (2007) Dev Biol , vol.308 , pp. 355-367
    • Hunter, M.P.1    Wilson, C.M.2    Jiang, X.3
  • 29
    • 0036340074 scopus 로고    scopus 로고
    • + cells are islet progenitors and are distinct from duct progenitors
    • + cells are islet progenitors and are distinct from duct progenitors. Development 2002, 129:2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 30
    • 79951539242 scopus 로고    scopus 로고
    • + ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • + ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 2011, 138:653-665.
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1    Dubois, C.L.2    Schaffer, A.E.3
  • 31
    • 67649657842 scopus 로고    scopus 로고
    • CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis
    • Le Lay J., Tuteja G., White P., et al. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab 2009, 10:55-62.
    • (2009) Cell Metab , vol.10 , pp. 55-62
    • Le Lay, J.1    Tuteja, G.2    White, P.3
  • 32
    • 80052745094 scopus 로고    scopus 로고
    • Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM)
    • Grant G.R., Farkas M.H., Pizarro A.D., et al. Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM). Bioinformatics 2011, 27:2518-2528.
    • (2011) Bioinformatics , vol.27 , pp. 2518-2528
    • Grant, G.R.1    Farkas, M.H.2    Pizarro, A.D.3
  • 33
    • 75249087100 scopus 로고    scopus 로고
    • EdgeR: a Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson M.D., McCarthy D.J., Smyth G.K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010, 26:139-140.
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 34
    • 84904650619 scopus 로고    scopus 로고
    • Isolation, culture and genetic manipulation of mouse pancreatic ductal cells
    • Reichert M., Takano S., Heeg S., et al. Isolation, culture and genetic manipulation of mouse pancreatic ductal cells. Nat Protoc 2013, 8:1354-1365.
    • (2013) Nat Protoc , vol.8 , pp. 1354-1365
    • Reichert, M.1    Takano, S.2    Heeg, S.3
  • 35
    • 32044438892 scopus 로고    scopus 로고
    • The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    • Pierreux C.E., Poll A.V., Kemp C.R., et al. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology 2006, 130:532-541.
    • (2006) Gastroenterology , vol.130 , pp. 532-541
    • Pierreux, C.E.1    Poll, A.V.2    Kemp, C.R.3
  • 36
    • 70350608140 scopus 로고    scopus 로고
    • Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation
    • Zhang H., Ables E.T., Pope C.F., et al. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev 2009, 126:958-973.
    • (2009) Mech Dev , vol.126 , pp. 958-973
    • Zhang, H.1    Ables, E.T.2    Pope, C.F.3
  • 37
    • 2342508500 scopus 로고    scopus 로고
    • Atranscriptional network in polycystic kidney disease
    • Gresh L., Fischer E., Reimann A., et al. Atranscriptional network in polycystic kidney disease. EMBO J 2004, 23:1657-1668.
    • (2004) EMBO J , vol.23 , pp. 1657-1668
    • Gresh, L.1    Fischer, E.2    Reimann, A.3
  • 38
    • 4243144134 scopus 로고    scopus 로고
    • Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    • Cano D.A., Murcia N.S., Pazour G.J., et al. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 2004, 131:3457-3467.
    • (2004) Development , vol.131 , pp. 3457-3467
    • Cano, D.A.1    Murcia, N.S.2    Pazour, G.J.3
  • 39
    • 33845661591 scopus 로고    scopus 로고
    • Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis
    • Cano D.A., Sekine S., Hebrok M. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 2006, 131:1856-1869.
    • (2006) Gastroenterology , vol.131 , pp. 1856-1869
    • Cano, D.A.1    Sekine, S.2    Hebrok, M.3
  • 40
    • 84868698484 scopus 로고    scopus 로고
    • Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    • Prevot P.P., Simion A., Grimont A., et al. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut 2012, 61:1723-1732.
    • (2012) Gut , vol.61 , pp. 1723-1732
    • Prevot, P.P.1    Simion, A.2    Grimont, A.3
  • 41
    • 0032585936 scopus 로고    scopus 로고
    • Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis
    • Coffinier C., Barra J., Babinet C., et al. Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis. Mech Dev 1999, 89:211-213.
    • (1999) Mech Dev , vol.89 , pp. 211-213
    • Coffinier, C.1    Barra, J.2    Babinet, C.3
  • 42
    • 84870803922 scopus 로고    scopus 로고
    • Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    • Kopp J.L., von Figura G., Mayes E., et al. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 2012, 22:737-750.
    • (2012) Cancer Cell , vol.22 , pp. 737-750
    • Kopp, J.L.1    von Figura, G.2    Mayes, E.3
  • 43
    • 36148955406 scopus 로고    scopus 로고
    • Externally applied pressure activates pancreatic stellate cells through the generation of intracellular reactive oxygen species
    • Asaumi H., Watanabe S., Taguchi M., et al. Externally applied pressure activates pancreatic stellate cells through the generation of intracellular reactive oxygen species. Am J Physiol Gastrointest Liver Physiol 2007, 293:G972-G978.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293 , pp. G972-G978
    • Asaumi, H.1    Watanabe, S.2    Taguchi, M.3
  • 44
    • 0034234599 scopus 로고    scopus 로고
    • Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts
    • Andoh A., Takaya H., Saotome T., et al. Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 2000, 119:211-219.
    • (2000) Gastroenterology , vol.119 , pp. 211-219
    • Andoh, A.1    Takaya, H.2    Saotome, T.3
  • 45
    • 0036098613 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis
    • Shek F.W., Benyon R.C., Walker F.M., et al. Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol 2002, 160:1787-1798.
    • (2002) Am J Pathol , vol.160 , pp. 1787-1798
    • Shek, F.W.1    Benyon, R.C.2    Walker, F.M.3
  • 46
    • 0025952414 scopus 로고
    • Pancreatic tissue and ductal pressures in chronic pancreatitis
    • Jalleh R.P., Aslam M., Williamson R.C. Pancreatic tissue and ductal pressures in chronic pancreatitis. Br J Surg 1991, 78:1235-1237.
    • (1991) Br J Surg , vol.78 , pp. 1235-1237
    • Jalleh, R.P.1    Aslam, M.2    Williamson, R.C.3
  • 47
    • 0029917121 scopus 로고    scopus 로고
    • Mechanical and neuroendocrine regulation of the endocrine heart
    • de Bold A.J., Bruneau B.G., Kuroski de Bold M.L. Mechanical and neuroendocrine regulation of the endocrine heart. Cardiovasc Res 1996, 31:7-18.
    • (1996) Cardiovasc Res , vol.31 , pp. 7-18
    • de Bold, A.J.1    Bruneau, B.G.2    Kuroski de Bold, M.L.3
  • 48
    • 0025361954 scopus 로고
    • Diverse biological actions of atrial natriuretic peptide
    • Brenner B.M., Ballermann B.J., Gunning M.E., et al. Diverse biological actions of atrial natriuretic peptide. Physiol Rev 1990, 70:665-699.
    • (1990) Physiol Rev , vol.70 , pp. 665-699
    • Brenner, B.M.1    Ballermann, B.J.2    Gunning, M.E.3
  • 49
    • 0028064629 scopus 로고
    • Atrial natriuretic peptide gene expression in the rat gastrointestinal tract
    • Gower W.R., Dietz J.R., Vesely D.L., et al. Atrial natriuretic peptide gene expression in the rat gastrointestinal tract. Biochem Biophys Res Commun 1994, 202:562-570.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 562-570
    • Gower, W.R.1    Dietz, J.R.2    Vesely, D.L.3
  • 50
    • 0031048622 scopus 로고    scopus 로고
    • Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver
    • Vollmar A.M., Paumgartner G., Gerbes A.L. Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver. Gut 1997, 40:145-150.
    • (1997) Gut , vol.40 , pp. 145-150
    • Vollmar, A.M.1    Paumgartner, G.2    Gerbes, A.L.3
  • 51
    • 0342470556 scopus 로고    scopus 로고
    • Regulation of atrial natriuretic peptide gene expression in gastric antrum by fasting
    • Gower W.R., Salhab K.F., Foulis W.L., et al. Regulation of atrial natriuretic peptide gene expression in gastric antrum by fasting. Am J Physiol Regul Integr Comp Physiol 2000, 278:R770-R780.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.278 , pp. R770-R780
    • Gower, W.R.1    Salhab, K.F.2    Foulis, W.L.3
  • 52
    • 0023485918 scopus 로고
    • Atrial natriuretic factor and exocrine pancreas: autoradiographic localization of binding sites and ultrastructural evidence for internalization of endogenous ANF
    • Chabot J.G., Morel G., Kopelman H., et al. Atrial natriuretic factor and exocrine pancreas: autoradiographic localization of binding sites and ultrastructural evidence for internalization of endogenous ANF. Pancreas 1987, 2:404-413.
    • (1987) Pancreas , vol.2 , pp. 404-413
    • Chabot, J.G.1    Morel, G.2    Kopelman, H.3
  • 53
    • 0023879728 scopus 로고
    • ANF and exocrine pancreas: ultrastructural autoradiographic localization in acinar cells
    • Chabot J.G., Morel G., Belles-Isles M., et al. ANF and exocrine pancreas: ultrastructural autoradiographic localization in acinar cells. Am J Physiol 1988, 254:E301-E309.
    • (1988) Am J Physiol , vol.254 , pp. E301-E309
    • Chabot, J.G.1    Morel, G.2    Belles-Isles, M.3
  • 54
    • 34548164149 scopus 로고    scopus 로고
    • Proteomic analysis of pancreatic zymogen granules: identification of new granule proteins
    • Rindler M.J., Xu C.F., Gumper I., et al. Proteomic analysis of pancreatic zymogen granules: identification of new granule proteins. JProteome Res 2007, 6:2978-2992.
    • (2007) JProteome Res , vol.6 , pp. 2978-2992
    • Rindler, M.J.1    Xu, C.F.2    Gumper, I.3
  • 56
    • 0036839540 scopus 로고    scopus 로고
    • Extracellular calcium sensing receptor in human pancreatic cells
    • Racz G.Z., Kittel A., Riccardi D., et al. Extracellular calcium sensing receptor in human pancreatic cells. Gut 2002, 51:705-711.
    • (2002) Gut , vol.51 , pp. 705-711
    • Racz, G.Z.1    Kittel, A.2    Riccardi, D.3
  • 57
    • 78049452453 scopus 로고    scopus 로고
    • Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice
    • e1-5
    • Behrendorff N., Floetenmeyer M., Schwiening C., et al. Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice. Gastroenterology 2010, 139:1711-1720. e1-5.
    • (2010) Gastroenterology , vol.139 , pp. 1711-1720
    • Behrendorff, N.1    Floetenmeyer, M.2    Schwiening, C.3
  • 58
    • 0031883674 scopus 로고    scopus 로고
    • Cleavage of GPI-anchored proteins from the plasma membrane activates apical endocytosis in pancreatic acinar cells
    • Freedman S.D., Kern H.F., Scheele G.A. Cleavage of GPI-anchored proteins from the plasma membrane activates apical endocytosis in pancreatic acinar cells. Eur J Cell Biol 1998, 75:163-173.
    • (1998) Eur J Cell Biol , vol.75 , pp. 163-173
    • Freedman, S.D.1    Kern, H.F.2    Scheele, G.A.3
  • 59
    • 33846910410 scopus 로고    scopus 로고
    • SOX9 is required for maintenance of the pancreatic progenitor cell pool
    • Seymour P.A., Freude K.K., Tran M.N., et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci USA 2007, 104:1865-1870.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1865-1870
    • Seymour, P.A.1    Freude, K.K.2    Tran, M.N.3
  • 60
    • 39749194712 scopus 로고    scopus 로고
    • Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    • Hezel A.F., Gurumurthy S., Granot Z., et al. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 2008, 28:2414-2425.
    • (2008) Mol Cell Biol , vol.28 , pp. 2414-2425
    • Hezel, A.F.1    Gurumurthy, S.2    Granot, Z.3
  • 61
    • 84876137598 scopus 로고    scopus 로고
    • Hereditary pancreatitis: endoscopic and surgical management
    • Ceppa E.P., Pitt H.A., Hunter J.L., et al. Hereditary pancreatitis: endoscopic and surgical management. JGastrointest Surg 2013, 17:847-857.
    • (2013) JGastrointest Surg , vol.17 , pp. 847-857
    • Ceppa, E.P.1    Pitt, H.A.2    Hunter, J.L.3
  • 62
    • 58249089866 scopus 로고    scopus 로고
    • The natural history of hereditary pancreatitis: a national series
    • Rebours V., Boutron-Ruault M.C., Schnee M., et al. The natural history of hereditary pancreatitis: a national series. Gut 2009, 58:97-103.
    • (2009) Gut , vol.58 , pp. 97-103
    • Rebours, V.1    Boutron-Ruault, M.C.2    Schnee, M.3
  • 63
    • 0035553707 scopus 로고    scopus 로고
    • Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study
    • Applebaum-Shapiro S.E., Finch R., Pfutzer R.H., et al. Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study. Pancreatology 2001, 1:439-443.
    • (2001) Pancreatology , vol.1 , pp. 439-443
    • Applebaum-Shapiro, S.E.1    Finch, R.2    Pfutzer, R.H.3
  • 64
    • 10144246566 scopus 로고    scopus 로고
    • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
    • Whitcomb D.C., Gorry M.C., Preston R.A., et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996, 14:141-145.
    • (1996) Nat Genet , vol.14 , pp. 141-145
    • Whitcomb, D.C.1    Gorry, M.C.2    Preston, R.A.3
  • 65
    • 78650425789 scopus 로고    scopus 로고
    • Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis
    • Schneider A., Larusch J., Sun X., et al. Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology 2011, 140:162-171.
    • (2011) Gastroenterology , vol.140 , pp. 162-171
    • Schneider, A.1    Larusch, J.2    Sun, X.3
  • 66
    • 37549072225 scopus 로고    scopus 로고
    • Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
    • Rosendahl J., Witt H., Szmola R., et al. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet 2008, 40:78-82.
    • (2008) Nat Genet , vol.40 , pp. 78-82
    • Rosendahl, J.1    Witt, H.2    Szmola, R.3
  • 67
    • 0032480253 scopus 로고    scopus 로고
    • Mutations of the cystic fibrosis gene in patients with chronic pancreatitis
    • Sharer N., Schwarz M., Malone G., et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. NEngl J Med 1998, 339:645-652.
    • (1998) NEngl J Med , vol.339 , pp. 645-652
    • Sharer, N.1    Schwarz, M.2    Malone, G.3
  • 68
    • 0032480346 scopus 로고    scopus 로고
    • Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis
    • Cohn J.A., Friedman K.J., Noone P.G., et al. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. NEngl J Med 1998, 339:653-658.
    • (1998) NEngl J Med , vol.339 , pp. 653-658
    • Cohn, J.A.1    Friedman, K.J.2    Noone, P.G.3
  • 69
    • 0033857452 scopus 로고    scopus 로고
    • SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    • Pfutzer R.H., Barmada M.M., Brunskill A.P., et al. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 2000, 119:615-623.
    • (2000) Gastroenterology , vol.119 , pp. 615-623
    • Pfutzer, R.H.1    Barmada, M.M.2    Brunskill, A.P.3
  • 70
    • 0034039578 scopus 로고    scopus 로고
    • Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    • Witt H., Luck W., Hennies H.C., et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 2000, 25:213-216.
    • (2000) Nat Genet , vol.25 , pp. 213-216
    • Witt, H.1    Luck, W.2    Hennies, H.C.3
  • 71
    • 84859984486 scopus 로고    scopus 로고
    • Genetic prevalence and characteristics in children with recurrent pancreatitis
    • Sultan M., Werlin S., Venkatasubramani N. Genetic prevalence and characteristics in children with recurrent pancreatitis. JPediatr Gastroenterol Nutr 2012, 54:645-650.
    • (2012) JPediatr Gastroenterol Nutr , vol.54 , pp. 645-650
    • Sultan, M.1    Werlin, S.2    Venkatasubramani, N.3
  • 72
    • 79952440277 scopus 로고    scopus 로고
    • The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis
    • Gasiorowska A., Talar-Wojnarowska R., Czupryniak L., et al. The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis. Dig Dis Sci 2011, 56:894-901.
    • (2011) Dig Dis Sci , vol.56 , pp. 894-901
    • Gasiorowska, A.1    Talar-Wojnarowska, R.2    Czupryniak, L.3
  • 73
    • 77955422140 scopus 로고    scopus 로고
    • Genetic, epidemiological, and clinical aspects of hereditary pancreatitis: a population-based cohort study in Denmark
    • Joergensen M.T., Brusgaard K., Cruger D.G., et al. Genetic, epidemiological, and clinical aspects of hereditary pancreatitis: a population-based cohort study in Denmark. Am J Gastroenterol 2010, 105:1876-1883.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1876-1883
    • Joergensen, M.T.1    Brusgaard, K.2    Cruger, D.G.3
  • 74
    • 33749143421 scopus 로고    scopus 로고
    • Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis
    • Keiles S., Kammesheidt A. Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. Pancreas 2006, 33:221-227.
    • (2006) Pancreas , vol.33 , pp. 221-227
    • Keiles, S.1    Kammesheidt, A.2
  • 75
    • 0033762091 scopus 로고    scopus 로고
    • Immunocytochemical characterization of murine Hex, a homeobox-containing protein
    • Ghosh B., Ganea G.R., Denson L.A., et al. Immunocytochemical characterization of murine Hex, a homeobox-containing protein. Pediatr Res 2000, 48:634-638.
    • (2000) Pediatr Res , vol.48 , pp. 634-638
    • Ghosh, B.1    Ganea, G.R.2    Denson, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.