Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes

Free Radical Biology and Medicine

Volumn 30, Issue 8, 2001, Pages 836-845

  Palomero, Jesús ^a   Galán, Ana I ^a   Muoz, María E ^a   Tuón, María J ^b   González Gallego, Javier ^b   Jiménez, Rafael ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITY OF LEÓN   (Spain)

Author keywords

Aging; Antioxidant enzymes; Cyclosporin A; Free radicals; Glutathione; Hepatotoxicity; Lipoperoxidation; Liver; Oxidative stress

Indexed keywords

CATALASE; CYCLOSPORIN A; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; LIVER ENZYME; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTASIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG INDUCED DISEASE; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER FUNCTION; LIVER TOXICITY; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; ANTIOXIDANTS; BILE ACIDS AND SALTS; BILIRUBIN; CATALASE; CYCLOSPORINE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; LIVER; MALE; OXIDATION-REDUCTION; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRANSAMINASES;

ANIMALIA;

EID: 0035871677     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00471-3     Document Type: Article

References (67)

1. Oxidative stress and superoxide dismutase in development, aging and gene regulation
2. Drugs and the aging liver
3. Lipid peroxidation, antioxidant protection and aging
4. In vivo pharmacological effects of cyclosporin and some analogues
5. Reevaluation of cyclosporine induced hepatotoxicity in the isolated perfused rat liver
6. Effect of cyclosporine A on rat liver and kidney glutathione content
7. Cyclosporine A hepatotoxicity: Effect of prolonged treatment with cyclosporine on biliary lipid secretion in the rat
8. S-adenosylmethionine protects against cyclosporine A-induced alterations in rat liver plasma membrane fluidity and functions
9. Inhibition of biliary glutathione secretion by cyclosporine A in the rat: Possible mechanisms and role in the cholestasis induced by the drug
10. Cyclosporin A-induced lipid peroxidation in human liver microsomes and its influence on cytocrome P-450
11. Oxidative stress in cyclosporin and azathioprine treated renal transplant patients
12. The effects of liver transplantation and cyclosporine on bile formation and lipid composition: An experimental study in the rat
13. Pharmacocinétique et effets hépatiques de la ciclosporine A
14. Chronic administration of cyclosporin A induces a decrease in hepatic excretory function in man
15. Cholestasis in heart transplant recipients treated with cyclosporine
16. Hepatobiliary and pancreatic complications of cyclosporine therapy in 466 renal transplant recipients
17. The metabolic effects of cyclosporin and tacrolimus
18. Cyclosporine A-induced oxidative stress in rat hepatocytes
19. Reactive oxygen species mediate the effects of cyclosporine A on human cultured mesangial cells
20. Cyclosporine A induced lipid peroxidation and influence on glucose-6-phosphatase in rat hepatic and renal microsomes
21. Effect of cyclosporin A and its metabolites and analogs on lipid peroxidation in rabbit renal microsomes
22. Impaired antioxidant defense system in the kidney tissues from rabbits treated with cyclosporine. Protective effects of vitamins E and C
23. Aluminum exacerbates cyclosporin induced nephrotoxicity in rats
24. Glutathione metabolism in cyclosporine A treated rats: Dose- and time-related alterations in liver and kidney
25. Age-related susceptibility to hepatotoxicants
26. Free radical theory of aging: The "free radical" diseases
27. Critical evaluation of the free radical theory: A proposal for the oxidative stress hypothesis
28. An update on the role of free radicals and antioxidant defense in human disease
29. Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats
30. Developmental changes of antioxidant enzymes in kidney and liver from rats
31. Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver
32. Effects of age on rat glutathione metabolism
33. Antioxidant enzyme response to exercise and aging
34. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
35. Effects of acute glutathione depletion induced by L-buthionine-(S,R)-sulfoximine on rat liver glucose-6-phosphatase activity
36. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
37. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase
38. Catalase in vitro
39. Glutathione peroxidase
40. γ-gutamylcysteine synthetase. Further purification. "Half of the sites" reactivity, subunits, and specificity
41. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation
42. Reversal of cyclosporine A-induced alterations in biliary secretion by S-adenosyl-L-methionine in rats
43. Interrelationship between hepatic, renal and pancreatic cyclosporine A-induced toxicity and its evolution with time in the rats
44. Dietary polyunsaturated fatty acids and aging modulate glutathione-related antioxidants in rat liver
45. Age-dependent modifications in rat hepatocyte antioxidant defense systems
46. Glutathione and lipid peroxidation in the aging rat
47. Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver
48. Glutathione dependent detoxication in liver tissue of aging rats
49. Glutathione: Toxicological implications
50. Chronic administration of cyclosporine A induces a decrease in hepatic excretory function in man. A study in heart transplanted patients with normal liver biochemistry
51. Cyclosporine A in patients receiving renal allografts from cadaver donors
52. Cyclosporine associated hepatotoxicity after allogenic marrow transplantation in man: Differentiation from other causes of post-transplant liver disease
53. Bile acid metabolism and biliary secretion in patient receiving orthotopic liver transplantation: Differing effects of cyclosporine and FK506
54. Aging and acute exercise enhance free radical generation in rat skeletal muscle
55. Evidence for involved of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
56. Altered lipid peroxidation/glutathione ratio in experimental extrahepatic cholestasis
57. Changes of lipid peroxide levels in blood and liver tissue of patients with obstructive jaundice
58. Toxicidad de la ciclosporina A sobre la homeostasis del glutatión en la rata: Importancia de la edad
59. Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria
60. The participation of coenzyme Q in free radical production and antioxidation
61. Influence of cyclosporin A treatment on intracellular membranes of hepatocytes
62. Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome-P-450 in liver microsomes from male and female rats
63. Oxidative stress and changes in liver antioxidant enzymes induced by experimental dicroceliosis in hamsters
64. Glutathione peroxidase, superoxide dismutase and catalase inactivation by peroxides and oxygen derived radicals
65. Inactivation of glutathione peroxidase by superoxide radical
66. Effect of type of dietary fat and ethanol on antioxidant enzyme mRNA induction in rat liver
67. Increased lipid peroxidation and imparied antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil