Mitochondrial dysfunction induced by NButyl- 1-(4-Dimethylamino)Phenyl-1,2,3,4- tetrahydro-β-carboline-3-carboxamide is required for cell death of trypanosoma cruzi

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Volpato, Hélito ^a   Desoti, Vânia Cristina ^a   Valdez, Rodrigo Hinojosa ^b   Ueda Nakamura, Tânia ^a   De Oliveira Silva, Sueli ^a   Sarragiotto, Maria Helena ^a   Nakamura, Celso Vataru ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b INSTITUTO FEDERAL DO PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; DNA; N BUTYL 1 (4 DIMETHYLAMINO)PHENYL 1,2,3,4 TETRAHYDRO BETA CARBOLINE 3 CARBOXAMIDE; OXYGEN; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; ANTITRYPANOSOMAL AGENT; CARBOLINE DERIVATIVE; N-BUTYL-1-(4-DIMETHYLAMINO)PHENYL-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE-3-CARBOXAMIDE; SINGLET OXYGEN;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOACCUMULATION; CELL DEATH; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CELL VOLUME; CHAGAS DISEASE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG STRUCTURE; EPIMASTIGOTE; FLUOROMETRY; LIPID COMPOSITION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; CELL SIZE; CHEMISTRY; DRUG EFFECTS; METABOLISM; MITOCHONDRION; SYNTHESIS;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ANILINE COMPOUNDS; CARBOLINES; CELL SIZE; DNA FRAGMENTATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84939217560     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130652     Document Type: Article

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