New imidazolidine derivatives as anti-Trypanosoma cruzi agents: Structure-activity relationships

Parasitology Research

Volumn 111, Issue 6, 2012, Pages 2361-2366

  Dos Santos Gomes, Fabiana Oliveira ^a   De Melo, Cristiane Moutinho Lagos ^b   Peixoto, Christina Alves ^b   De Lima, Maria Do Carmo Alves ^a   Galdino, Suely Lins ^a   Pereira, Valéria Rêgo Alves ^b   Da Rocha Pitta, Ivan ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 BROMOBENZYL) 5 (INDOL 3 YLMETHYLENE) 2 THIOXOIMIDAZOLIDIN 4 ONE; 5 (INDOL 3 YLMETHYLENE) 3(4 NITROBENZYL) 2 THIOXOIMIDAZOLIDIN 4 ONE; BENZNIDAZOLE; IMIDAZOLIDINE DERIVATIVE; NIFURTIMOX; NN 100; NN 52; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; EPIMASTIGOTE; IC 50; IN VITRO STUDY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

IMIDAZOLIDINES; MICROSCOPY, ELECTRON; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 84872355452     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-012-3091-7     Document Type: Article

References (14)

1. Braga MV, Urbina JA, De Souza W (2004) Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi. Int J Antimicrob Agents 24:72-78
2. Caterina MC, Perillo IA, Boiani L, Pezaroglo H, Cerecetto H, González M, Salerno A (2008) Imidazolidines as new anti-Trypanosoma cruzi agents: biological evaluation and structure-activity. Bioorg Med Chem 16:2226-2234
3. Coura JR, De Castro SL (2002) A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 97:3-24
4. De Souza W (2008) Electron microscopy of trypanosomes-a historical view. Mem Inst Oswaldo Cruz 103:313-325
5. De Souza W (2009) Structural organization of Trypanosoma cruzi. Mem Inst Oswaldo Cruz 104:89-100
6. Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L, Kroemer G (2007) Cell death modalities: classification and pathophysiological implications. Cell Death Differ 14:1237-1266
7. Garzoni LR, Caldera A, Meirelles MNL, De Castro SL, Do Campo R, Meints GA, Oldfield E, Urbina JA (2004) Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi. Int J Antimicrob Agents 23:273-285
8. Isasi SC, Rodríguez M, Pereira BMI, Díaz-luján C, Fretes RE, Haüen DI (2009) Trypanosoma cruzi: altered parasites after in vitro treatment with gangliosides, a therapeutic agent in experimental Chagas' disease. Exp Parasitol 122:218-225
9. Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P, Zhivotovsky B, Blagosklonny MV, Malorni W, Knight RA, Piacentini M, Nagata S, Melino G (2009) Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ 16:3-11
10. Maya JD, Cassels BK, Iturriaga-Vásquez P, Ferreira J, Faúndez M, Galanti N, Ferreira A, Morello A (2007) Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host. Comp Biochem Physiol, Part A: Mol Integr Physiol 146:601-620
11. Neves JKLA, Botelho SPS, Melo CML, Pereira VRA, Lima MCA, Pitta IR, Albuquerque MCPA, Galdino SL (2010) Biological and immunological activity of new imidazolidines against adult worms of Schistosoma mansoni. Parasitol Res 107:531-538
12. Santoro GF, Cardoso MG, Guimarães LGL, Salgado APSP, Menna- Barreto RFS, Soares MJ (2007) Effect of oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils on Trypanosoma cruzi (Protozoa: Kinetoplastida) growth and ultrastructure. Parasitol Res 100:783-790
13. Van Hellemond JJ, Opperdoes FR, Tielens AG (2005) The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei. Biochem Soc Trans 33:967-971
14. World Health Organization (2002) Control of Chagas disease, WHO Technical report series, no. 905. WHO, Geneva