Epithelial mesenchymal transition in smokers: Large versus small airways and relation to airflow obstruction

International Journal of COPD

Volumn 10, Issue 1, 2015, Pages 1515-1524

  Mahmood, Malik Quasir ^a   Sohal, Sukhwinder Singh ^a   Shukla, Shakti Dhar ^a   Ward, Chris ^b   Hardikar, Ashutosh ^c   Noor, Wan Danial ^a   Muller, Hans Konrad ^a   Knight, Darryl A ^d   Walters, Eugene Haydn ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c ROYAL HOBART HOSPITAL   (Australia)

^d UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

EGFR; EMT; Fragmentation; S100A4; Small airways; Vimentin

Indexed keywords

CALVASCULIN; COLLAGEN TYPE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; VIMENTIN; EGFR PROTEIN, HUMAN; PROTEIN S 100; S100A4 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; AIRWAY SIZE; ARTICLE; BASEMENT MEMBRANE; CANCER PATIENT; CELL ACTIVATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; MALE; PROTEIN EXPRESSION; RESPIRATORY TRACT PARAMETERS; RETICULAR BASEMENT MEMBRANE FRAGMENTATION; SMOKING; VASCULARIZATION; ADVERSE EFFECTS; BIOPSY; CASE CONTROL STUDY; CHEMISTRY; COMPARATIVE STUDY; EPITHELIUM CELL; LUNG; LUNG NEOPLASMS; METABOLISM; MIDDLE AGED; PATHOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; STATISTICAL MODEL;

AGED; BASEMENT MEMBRANE; BIOMARKERS, TUMOR; BIOPSY; CASE-CONTROL STUDIES; COLLAGEN TYPE IV; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LINEAR MODELS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTOR, EPIDERMAL GROWTH FACTOR; S100 CALCIUM-BINDING PROTEIN A4; S100 PROTEINS; SMOKING; VIMENTIN;

EID: 84939216049     PISSN: 11769106     EISSN: 11782005     Source Type: Journal    
DOI: 10.2147/COPD.S81032     Document Type: Article

References (34)

1. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442.
2. Fullerton DG, Bruce N, Gordon SB. Indoor air pollution from biomass fuel smoke is a major health concern in the developing world. Trans R Soc Trop Med Hyg. 2008;102(9):843–851.
3. Hogg JC, McDonough JE, Suzuki M. Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging. Chest. 2013;143(5):1436–1443.
4. Dunnill MS, Ryder R. A quantitative study of the relationship between chronic bronchitis, emphysema and smoking. Chest. 1971;59(suppl):35S+.
5. Sohal SS, Reid D, Soltani A, et al. Reticular basement membrane frag­mentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology. 2010;15(6):930–938.
6. Sohal SS, Reid D, Soltani A, et al. Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary. Respir Res. 2011;12:130.
7. Soltani A, Muller HK, Sohal SS, et al. Distinctive characteristics of bronchial reticular basement membrane and vessel remodelling in chronic obstructive pulmonary disease (COPD) and in asthma: they are not the same disease. Histopathology. 2012;60(6):964–970.
8. Sohal SS, Walters EH. Epithelial mesenchymal transition (EMT) in small airways of COPD patients. Thorax. 2013;68(8):783–784.
9. Milara J, Peiro T, Serrano A, Cortijo J. Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Thorax. 2013;68(5):410–420.
10. Walters EH, Reid D, Soltani A, Ward C. Angiogenesis: a potentially critical part of remodelling in chronic airway diseases? Pharmacol Ther. 2008;118(1):128–137.
11. Hiroshima K, Iyoda A, Shibuya K, et al. Evidence of neoangiogenesis and an increase in the number of proliferating cells within the bronchial epithelium of smokers. Cancer. 2002;95(7):1539–1545.
12. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol. 2008;19(12):2282–2287.
13. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420–1428.
14. Parimon T, Chien JW, Bryson CL, McDonell MB, Udris EM, Au DH. Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;175(7):712–719.
15. Yang IA, Relan V, Wright CM, et al. Common pathogenic mechanisms and pathways in the development of COPD and lung cancer. Expert Opin Ther Targets. 2011;15(4):439–456.
16. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
17. GOLD. Global Initiative for Chronic Obstructive Pulmonary Lung Disease. 2013. Available from: http://www.goldcopd.org
18. Hogg JC, Chu F, Utokaparch S, et al. The nature of small airway obstruc­tion in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(26):2645–2653.
19. Sohal SS, Soltani A, Reid D, et al. A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial-mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study. Int J Chron Obstruct Pulmon Dis. 2014;9:533–542.
20. Shukla SD, Sohal SS, Mahmood MQ, Reid D, Muller HK, Walters EH. Airway epithelial platelet-activating factor receptor expression is mark­edly upregulated in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014;9:853–861.
21. Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol (1985). 1992;72(3):1016–1023.
22. Prudkin L, Liu DD, Ozburn NC, et al. Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung. Mod Pathol. 2009;22(5):668–678.
23. Burgel PR, Bourdin A, Chanez P, et al. Update on the roles of distal airways in COPD. Eur Respir Rev. 2011;20(119):7–22.
24. Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis*: the myofibroblast in focus. Chest. 2007;132(4):1311–1321.
25. Milara J, Serrano A, Peiró T, et al. Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition. Eur Respir J. 2013;41(6):1264–1274.
26. Coward W, Deacon K, Pang L. Activation of epidermal growth factor receptor (EGFR) is required for Tgfβ1-induced epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF). Am J Respir Crit Care Med. 2013;187:A4818.
27. Milara J, Peiró T, Serrano A, et al. Roflumilast N-oxide inhibits bron­chial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD. Pulm Pharmacol Ther. 2014;28(2):138–148.
28. Wang Q, Wang Y, Zhang Y, Zhang Y, Xiao W. The role of uPAR in epithelial-mesenchymal transition in small airway epithelium of patients with chronic obstructive pulmonary disease. Respir Res. 2013;14:67.
29. Yang K, Song Y, Tang YB, et al. mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells. BMC Pulm Med. 2014;14:53.
30. Keith RL, Miller YE, Gemmill RM, et al. Angiogenic squamous dys­plasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res. 2000;6(5):1616–1625.
31. Fontanini G, Vignati S, Bigini D, et al. Neoangiogenesis: a putative marker of malignancy in non-small-cell lung cancer (NSCLC) develop­ment. Int J Cancer. 1996;67(5):615–619.
32. Sarrazin S, Maurage C, Delmas D, Lassalle P, Delehedde M. Endocan as a biomarker of endothelial dysfunction in cancer. J Cancer Sci Ther. 2010;2(6):47–52.
33. Iwatsuki M, Mimori K, Yokobori T, et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 2010;101(2):293–299.
34. Pain M, Bermudez O, Lacoste P, et al. Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype. Eur Respir Rev. 2014;23(131):118–130.