Circulating lipids are associated with alcoholic liver cirrhosis and represent potential biomarkers for risk assessment

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Meikle, Peter J ^a   Mundra, Piyushkumar A ^a   Wong, Gerard ^a   Rahman, Khairunnessa ^b   Huynh, Kevin ^a   Barlow, Christopher K ^a   Duly, Alastair M P ^c   Haber, Paul S ^b,d   Whitfield, John B ^e   Seth, Devanshi ^b,d  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b University of Sydney   (Australia)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKYLPHOSPHATIDYLCHOLINE; ASPARTATE AMINOTRANSFERASE; CERAMIDE TRIHEXOSIDE; CHOLESTEROL; DIHEXOSYLCERAMIDE; GLYCEROLIPID; GLYCOSPHINGOLIPID; HEMOGLOBIN; LYSOALKYLPHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; SERUM ALBUMIN; SPHINGOLIPID; STEROL; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; LIPID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LEUKOCYTE COUNT; LIPID ANALYSIS; MALE; MEASUREMENT ACCURACY; MIDDLE AGED; MOLECULAR DYNAMICS; RECEIVER OPERATING CHARACTERISTIC; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THROMBOCYTE COUNT; BLOOD;

ADULT; BIOMARKERS; FEMALE; HUMANS; LIPIDS; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MIDDLE AGED;

EID: 84939172446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130346     Document Type: Article

References (30)

1. NIH National Institute in Alcohol Abuse and Alcoholism.
2. Seitz HK, Stickel F (2006) Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 387: 349-360. PMID: 16606331
3. Lakshman MR (2004) Some novel insights into the pathogenesis of alcoholic steatosis. Alcohol 34: 45-48. PMID: 15670665
4. Sozio MS, Liangpunsakul S, Crabb D (2010) The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. Semin Liver Dis 30: 378-390. doi:10.1055/s-0030-1267538 PMID: 20960377
5. Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN (2009) Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas 38: e47-52. PMID: 19248221
6. Siler SQ, Neese RA, Hellerstein MK (1999) De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am J Clin Nutr 70: 928-936. PMID: 10539756
7. Clugston RD, Jiang H, Lee MX, Piantedosi R, Yuen JJ, Ramakrishnan R, et al. (2011) Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. J Lipid Res 52: 2021-2031. doi:10.1194/jlr.M017368 PMID: 21856784
8. Zhao Z, Yu M, Crabb D, Xu Y, Liangpunsakul S (2011) Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice. Alcohol Clin Exp Res 35: 229-234. doi:10.1111/j.1530-0277.2010. 01338.x PMID: 21058963
9. Banerji MA, Buckley MC, Chaiken RL, Gordon D, Lebovitz HE, Kral JG (1995) Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM. Int J Obes Relat Metab Disord 19: 846-850. PMID: 8963350
10. Ryysy L, Hakkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, et al. (2000) Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49: 749-758. PMID: 10905483
11. Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, et al. (2002) The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51: 797-802. PMID: 11872682
12. Bajaj M, Suraamornkul S, Pratipanawatr T, Hardies LJ, Pratipanawatr W, Glass L, et al. (2003) Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes. Diabetes 52: 1364-1370. PMID: 12765945
13. Hart CL, Batty GD, Morrison DS, Mitchell RJ, Smith GD (2010) Obesity, overweight and liver disease in the Midspan prospective cohort studies. Int J Obes (Lond) 34: 1051-1059. doi:10.1038/ijo.2010.20 PMID: 20142829
14. Liu B, Balkwill A, Reeves G, Beral V (2010) Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study. BMJ 340: c912. doi:10.1136/bmj.c912 PMID: 20223875
15. Meikle PJ, Wong G, Barlow CK, Weir JM, Greeve MA, Macintosh GL, et al. (2013) Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes. PLoS One 8: e74341. doi:10. 1371/journal.pone.0074341 PMID: 24086336
16. Weir JM, Wong G, Barlow CK, Greeve MA, Kowalczyk A, Almasy L, et al. (2013) Plasma lipid profiling in a large population-based cohort. J Lipid Res 54: 2898-2908. doi:10.1194/jlr.P035808 PMID: 23868910
17. Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M (1993) Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II. Addiction 88: 791-804. PMID: 8329970
18. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B (Methodological). pp. 289-300.
19. Kononenko I, Simec E, Robnik-Sikonja M (1997) Overcoming the Myopia of Inductive Learning Algorithms with RELIEFF. Applied Intelligence 7: 39-55.
20. Chang C-C, Lin C-J (2011) LIBSVM: A library for support vector machines. ACM Trans Intell Syst Technol 2: 1-27.
21. Lieber CS (1992) Medical and nutritional complications of alcoholism: mechanisms and management: Plenum Medical Book Co.
22. Rasineni K, Casey CA (2012) Molecular mechanism of alcoholic fatty liver. Indian J Pharmacol 44: 299-303. doi:10.4103/0253-7613.96297 PMID: 22701235
23. Uthus EO, Skurdal DN, Cornatzer WE (1976) Effect of ethanol ingestion on choline phosphotransferase and phosphatidyl ethanolamine methyltransferase activities in liver microsomes. Lipids 11: 641-644. PMID: 186686
24. Savolainen MJ, Baraona E, Pikkarainen P, Lieber CS (1984) Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon. J Lipid Res 25: 813-820. PMID: 6491527
25. Nikkila K, Nissinen MJ, Gylling H, Isoniemi H, Miettinen TA (2008) Serum sterols in patients with primary biliary cirrhosis and acute liver failure before and after liver transplantation. J Hepatol 49: 936-945. doi:10.1016/j.jhep.2008.07.026 PMID: 18926587
26. Chatterjee S, Bedja D, Mishra S, Amuzie C, Avolio A, Kass D, et al. (2014) Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apo E-/-Mice and Rabbits Fed a High Fat and Cholesterol Diet. Circulation.
27. Glaros EN, Kim WS, Quinn CM, Wong J, Gelissen I, Jessup W, et al. (2005) Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. J Biol Chem 280: 24515-24523. PMID: 15890646
28. Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, et al. (2014) Acyl-CoA: cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells. J Hepatol.
29. Ydreborg M, Lisovskaja V, Lagging M, Brehm Christensen P, Langeland N, Buhl MR, et al. (2014) A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis. PLoS One 9: e93601. doi:10.1371/journal.pone.0093601 PMID: 24699777
30. Lijmer JG, Mol BW, Heisterkamp S, Bonsel GJ, Prins MH, van der Meulen JH, et al. (1999) Empirical evidence of design-related bias in studies of diagnostic tests. JAMA 282: 1061-1066. PMID: 10493205