Serum sterols in patients with primary biliary cirrhosis and acute liver failure before and after liver transplantation

Journal of Hepatology

Volumn 49, Issue 6, 2008, Pages 936-945

  Nikkilä, Katriina ^a   Nissinen, Markku J ^b   Gylling, Helena ^c   Isoniemi, Helena ^a   Miettinen, Tatu A ^b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Acute liver failure; Cholestasis; Liver transplantation; Non cholesterol sterols; Phytosterols; Primary biliary cirrhosis

Indexed keywords

AZATHIOPRINE; BILIRUBIN; BIOCHEMICAL MARKER; CALCINEURIN INHIBITOR; CAMPESTEROL; CHOLESTANOL; CYCLOSPORIN; LATHOSTEROL; METHYLPREDNISOLONE; PHYTOSTEROL; PREALBUMIN; STEROL; TACROLIMUS;

ALBUMIN DIALYSIS; ARTICLE; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; FEMALE; HOMEOSTASIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIPID BLOOD LEVEL; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL;

ADULT; BILIRUBIN; BIOLOGICAL MARKERS; CHOLESTEROL; FEMALE; HUMANS; LIVER CIRRHOSIS, BILIARY; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PHYTOSTEROLS; PREALBUMIN; STEROLS;

EID: 55749090956     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.07.026     Document Type: Article

References (29)

1. Goldstein J.L., and Brown M.S. Regulation of the mevalonate pathway. Nature 343 (1990) 425-430
2. Tilvis R.S., and Miettinen T.A. Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutr 43 (1986) 92-97
3. Miettinen T.A., Tilvis R.S., and Kesäniemi Y.A. Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism 38 (1989) 136-140
4. Miettinen T.A., Tilvis R.S., and Kesäniemi Y.A. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131 (1990) 20-31
5. Nissinen M.J., Gylling H., and Miettinen T.A. Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men. Br J Nutr 99 (2008) 370-378
6. Yu L., Hammer R.E., Li-Hawkins K., Von Bergmann K., Lutjohann D., Cohen J.C., et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA 33 (2002) 16237-16242
7. Davis HR Jr. H.R., Zhu L.-J., Hoos L.M., Tetzloff G., Maguire M., Liu J., et al. Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J Biol Chem 32 (2004) 33586-33592
8. Repa J.J., Berge K.E., Pomajzl C., Richardson J.A., Hobbs H., and Mangelsdorf D.J. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β. J Biol Chem 277 (2002) 18793-18800
9. Kaplan M.M., and Gershwin M.E. Primary biliary cirrhosis. N Engl J Med 353 (2005) 1261-1273
10. Nikkilä K., Höckerstedt K., and Miettinen T.A. High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantatation. Hepatology 13 (1991) 663-669
11. Gylling H., Vuoristo M., Färkkilä M., and Miettinen T.A. The metabolism of cholestanol in primary biliary cirrhosis. J Hepatol 24 (1996) 444-451
12. Yee H.F., and Lidofsky S.D. Acute liver failure. In: Feldman M., Friedman L.S., and Sleisenger M.H. (Eds). Sleisenger and Fordtrans's gastrointestinal and liver disease. 7th ed. (2002), Saunders 1567-1576
13. Ostapowicz G., Fontana R.J., Schiødt F.V., Larson A., Davern T.J., Han S.H., et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 137 (2002) 947-954
14. Brandsaeter B., Höckerstedt K., Friman S., Ericzon B.G., Kirkegaard P., Isoniemi H., et al. Fulminant hepatic failure: outcome after listing for highly urgent liver transplantation - 12 years experience in the nordic countries. Liver Transpl 8 (2002) 1055-1062
15. Nikkilä K., Höckerstedt K., and Miettinen T.A. Serum and hepatic cholestanol, squalene and noncholesterol sterols in man: a study on liver transplantation. Hepatology 15 (1992) 863-870
16. Nikkilä K., Miettinen T.A., Höckerstedt K.V.A., and Isoniemi H. Sterol parameters as markers of liver function in primary biliary cirrhosis before and after liver transplantation. Transpl Int 18 (2005) 221-225
17. Miettinen T.A., Klett E.L., Gylling H., Isoniemi H., and Patel S.B. Liver transplantation in a patient with sitosterolemia and cirrhosis. Gastroenterology 130 (2006) 542-547
18. Miettinen T.A. Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res 29 (1988) 43-51
19. Miettinen T.A., and Koivisto P. Non-cholesterol sterols and bile acid production in hypercholesterolaemic patients with ileal by-pass. In: Paumgartner G., Stiehl A., and Gerok W. (Eds). Bile acids and cholesterol in health and disease (1983), MTP Press, Lancaster, PA 183-187
20. Miettinen T.A., Gylling H., Strandberg T., and Sarna S. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. BMJ 316 (1998) 1127-1130
21. Gylling H., Hallikainen M., Pihlajamäki J., Agren J., Laakso M., Rajaratnam R.A., et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res 45 (2004) 1660-1665
22. Bhattacharyya A.K., Lin D.S., and Connor W.E. Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover, and tissue deposition. J Lipid Res 48 (2007) 185-192
23. Gautam M., Cheruvattath R., and Balan V. Recurrence of autoimmune liver disease after liver transplantation: a systematic review. Liver Transpl 12 (2006) 1813-1824
24. Nikkilä K., Höckerstedt K., and Miettinen T.A. Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. Clin Chim Acta 208 (1992) 205-218
25. Siirtola A., Ketomäki A., Miettinen T.A., Gylling H., Lehtimäki T., Holmberg C., et al. Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. Transplantation 81 (2006) 327-334
26. Rautiainen H., Salomaa V., Niemelä S., Karvonen A.L., Nurmi H., Isoniemi H., et al. Prevalence and incidence of primary biliary cirrhosis are increasing in Finland. Scand J Gastroenterol 42 (2007) 1-7
27. Brown M.S., and Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 232 (1986) 34-47
28. Miettinen T.A., Gylling H., Viikari J., Lehtimäki T., and Raitakari O.T. Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols. The cardiovascular risk in young Finns study. Atherosclerosis 200 (2008) 177-183
29. Bhattacharyya A.K., and Connor W.E. β-Sitosterolemia and xanthomatosis A newly described lipid storage disease in two sisters. J Clin Invest 53 (1974) 1033-1043