Polyclonal recipient ntregs are superior to donor or third-party tregs in the induction of transplantation tolerance

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Pilat, Nina ^a   Klaus, Christoph ^a   Hock, Karin ^a   Baranyi, Ulrike ^a   Unger, Lukas ^a   Mahr, Benedikt ^a   Farkas, Andreas M ^a   Wrba, Fritz ^a   Wekerle, Thomas ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA; ALLOANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; FEMALE; GRAFT RECIPIENT; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; ANIMAL; DONOR; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNOLOGY; SKIN TRANSPLANTATION;

ANIMALS; BONE MARROW TRANSPLANTATION; FEMALE; GRAFT SURVIVAL; ISOANTIBODIES; MICE; SKIN TRANSPLANTATION; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS; TRANSPLANT RECIPIENTS; TRANSPLANTATION CHIMERA; TRANSPLANTATION TOLERANCE;

EID: 84939156754     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/562935     Document Type: Article

References (35)

1. K. E. Lamb, S. Lodhi, and H. -U. Meier-Kriesche, "Longterm renal allograft survival in the United States: a critical reappraisal, " The American Journal of Transplantation, vol. 11, no. 3, pp. 450-462, 2011.
2. Z. M. El-Zoghby, M. D. Stegall, D. J. Lager et al. , "Identifying specific causes of kidney allograft loss, " American Journal of Transplantation, vol. 9, no. 3, pp. 527-535, 2009.
3. J. M. M. Granados, G. Benichou, and T. Kawai, "Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance, " Current Opinion in Organ Transplantation, vol. 20, no. 1, pp. 49-56, 2015.
4. N. Pilat and T. Wekerle, "Transplantation tolerance through mixed chimerism, " Nature Reviews Nephrology, vol. 6, no. 10, pp. 594-605, 2010.
5. B. Gyurkocza and B. M. Sandmaier, "Conditioning regimens for hematopoietic cell transplantation: one size does not fit all, " Blood, vol. 124, no. 3, pp. 344-353, 2014.
6. T. Wekerle, J. Kurtz, H. Ito et al. , "Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment, " Nature Medicine, vol. 6, no. 4, pp. 464-469, 2000.
7. M. M. Durham, A. W. Bingaman, A. B. Adams et al. , "Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donorspecific tolerance without cytoreductive conditioning, " Journal of Immunology, vol. 165, no. 1, pp. 1-4, 2000.
8. M. Girgis, C. Hallemeier, W. Blum et al. , "Chimerism and clinical outcomes of 110 recipients of unrelated donor bone marrow transplantswho underwent conditioning with low-dose, singleexposure total body irradiation and cyclophosphamide, " Blood, vol. 105, no. 8, pp. 3035-3041, 2005.
9. Y. Reisner and M. F. Martelli, "Transplantation tolerance induced by 'mega dose' CD34+ cell transplants, " Experimental Hematology, vol. 28, no. 2, pp. 119-127, 2000.
10. N. Pilat, U. Baranyi, C. Klaus et al. , "Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning, "The American Journal of Transplantation, vol. 10, no. 4, pp. 751-762, 2010.
11. N. Pilat and T. Wekerle, "Combining Treg therapy with mixed chiemrism: getting the best of both worlds, " Chimerism, vol. 1, no. 1, pp. 1-4, 2010.
12. N. Pilat, A. M. Farkas, B. Mahr et al. , "T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerismmodel, "The Journal ofHeart and Lung Transplantation, vol. 33, no. 4, pp. 429-437, 2014.
13. E. Jaeckel, H. Von Boehmer, and M. P. Manns, "Antigenspecific FoxP3-transduced T-cells can control established type 1 diabetes, " Diabetes, vol. 54, no. 2, pp. 306-310, 2005.
14. S. E. Allan, L. Passerini, R. Bacchetta et al. , "Therole of 2 FOXP3 isoforms in the generation of human CD4+ Tregs, " The Journal of Clinical Investigation, vol. 115, no. 11, pp. 3276-3284, 2005.
15. S. Fu, N. Zhang, A. C. Yopp et al. , "TGF-β induces Foxp3 + T-regulatory cells from CD4 + CD25 -precursors, " American Journal of Transplantation, vol. 4, no. 10, pp. 1614-1627, 2004.
16. R. J. DiPaolo, C. Brinster, T. S. Davidson, J. Andersson, D. Glass, and E. M. Shevach, "Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells, " Journal of Immunology, vol. 179, no. 7, pp. 4685-4693, 2007.
17. D. Q. Tran, H. Ramsey, and E. M. Shevach, "Induction of FOXP3 expression in naive human CD4+FOXP3-T cells by T-cell receptor stimulation is transforming growth factor-β-dependent but does not confer a regulatory phenotype, " Blood, vol. 110, no. 8, pp. 2983-2990, 2007.
18. E. M. Shevach, R. A. DiPaolo, J. Andersson, D. -M. Zhao, G. L. Stephens, and A. M. Thornton, "The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells, " Immunological Reviews, vol. 212, pp. 60-73, 2006.
19. A. M. Thornton and E. M. Shevach, "Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific, " Journal of Immunology, vol. 164, no. 1, pp. 183-190, 2000.
20. A. G. Levine, A. Arvey, W. Jin, and A. Y. Rudensky, "Continuous requirement for the TCR in regulatory T cell function, " Nature Immunology, vol. 15, no. 11, pp. 1070-1078, 2014.
21. J. Zhu and E. M. Shevach, "TCR signaling fuels T(reg) cell suppressor function, " Nature Immunology, vol. 15, no. 11, pp. 1002-1003, 2014.
22. L. C. Cendales, J. Kanitakis, S. Schneeberger et al. , "The Banff 2007 working classification of skin-containing composite tissue allograft pathology, " American Journal of Transplantation, vol. 8, no. 7, pp. 1396-1400, 2008.
23. T. Wekerle, M. H. Sayegh, J. Hill et al. , "Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance, " Journal of ExperimentalMedicine, vol. 187, no. 12, pp. 2037-2044, 1998.
24. P. Blaha, S. Bigenzahn, Z. Koporc et al. , "The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade, " Blood, vol. 101, no. 7, pp. 2886-2893, 2003.
25. M. A. Curotto de Lafaille and J. J. Lafaille, "Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?" Immunity, vol. 30, no. 5, pp. 626-635, 2009.
26. A. Toker, D. Engelbert, G. Garg et al. , "Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus, " The Journal of Immunology, vol. 190, no. 7, pp. 3180-3188, 2013.
27. H. Xu, P. M. Chilton, Y. Huang, C. L. Schanie, and S. T. Ildstad, "Production of donor T cells is critical for induction of donorspecific tolerance and maintenance of chimerism, " Journal of Immunology, vol. 172, no. 3, pp. 1463-1471, 2004.
28. N. Pilat, C. Klaus, M. Gattringer et al. , "Therapeutic efficacy of polyclonal tregs does not require rapamycin in a low-dose irradiation bone marrow transplantation model, " Transplantation, vol. 92, no. 3, pp. 280-288, 2011.
29. W. F. N. Chan, H. Razavy, and C. C. Anderson, "Differential susceptibility of allogeneic targets to indirect CD4 immunity generates split tolerance, " Journal of Immunology, vol. 181, no. 7, pp. 4603-4612, 2008.
30. D. A. Horwitz, S. G. Zheng, J. Wang, and J. D. Gray, "Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg, " European Journal of Immunology, vol. 38, no. 4, pp. 912-915, 2008.
31. J. L. Riley, C. H. June, and B. R. Blazar, "Human T regulatory cell therapy: take a billion or so and call me in the morning, " Immunity, vol. 30, no. 5, pp. 656-665, 2009.
32. O. Joffre, T. Santolaria, D. Calise et al. , "Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes, " Nature Medicine, vol. 14, no. 1, pp. 88-92, 2008.
33. A. M. Hanash and R. B. Levy, "Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation, " Blood, vol. 105, no. 4, pp. 1828-1836, 2005.
34. P. A. Taylor, A. Panoskaltsis-Mortari, J. M. Swedin et al. , "L-selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection, " Blood, vol. 104, no. 12, pp. 3804-3812, 2004.
35. W. R. Godfrey, D. J. Spoden, Y. G. Ge et al. , "Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function, " Blood, vol. 105, no. 2, pp. 750-758, 2005.