Production of Donor T Cells Is Critical for Induction of Donor-Specific Tolerance and Maintenance of Chimerism

Journal of Immunology

Volumn 172, Issue 3, 2004, Pages 1463-1471

  Xu, Hong ^a   Chilton, Paula M ^a   Huang, Yiming ^a   Schanie, Carrie L ^a   Ildstad, Suzanne T ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; OKT 8;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CHIMERA; CONTROLLED STUDY; DONOR; DOSE RESPONSE; GRAFT REJECTION; HEMATOPOIETIC STEM CELL; IMMUNOLOGICAL TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; T LYMPHOCYTE;

EID: 1642566656     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.3.1463     Document Type: Article

References (42)

1. Colson, Y. L., S. M. Wren, M. J. Schuchert, K. D. Patrene, P. C. Johnson, S. S. Boggs, and S. T. Ildstad. 1995. A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hemopoietic histocompatibility barriers. J. Immunol. 155:4179.
2. Colson, Y. L., H. Li, S. S. Boggs, K. D. Patrene, P. C. Johnson, and S. T. Ildstad. 1996. Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach. J. Immunol. 157:2820.
3. + cells permits engraftment of bone marrow stem cells and tolerance induction with minimal conditioning. Surgery 122:221.
4. Tomita, Y., Y. Nishimura, N. Harada, M. Eto, K. Ayukawa, Y. Yoshikai, and K. Nomoto. 1990. Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion. J. Immunol. 145:4026.
5. Wekerle, T., J. Kurtz, H. Ito, J. V. Ronquillo, V. Dong, G. Zhao, J. Shaffer, M. H. Sayegh, and M. Sykes. 2000. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat. Med. 6:464.
6. Gilliet, M., and Y. J. Liu. 2002. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 195:695.
7. Rissoan, M. C., V. Soumelis, N. Kadowaki, G. Grouard, F. Briere, M. R. de Waal, and Y. J. Liu. 1999. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283:1183.
8. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685-711.
9. Hisanaga, M., J. Hundrieser, K. Boker, K. Uthoff, G. Raddatz, T. Wahlers, K. Wonigeit, R. Pichlmayr, and H. J. Schlitt. 1996. Development, stability, and clinical correlations of allogeneic microchimerism after solid organ transplantation. Transplantation 61:40.
10. Elwood, E. T., C. P. Larsen, D. H. Maurer, K. L. Routenberg, J. F. Neylan, J. D. Whelchel, D. P. O'Brien, and T. C. Pearson. 1997. Microchimerism and rejection in clinical transplantation. Lancet 349:1358.
11. Umemura, A., H. Morita, L. Chang, X., S. Tahan, A. P. Monaco, and T. Maki. 2001. Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J. Immunol. 167:3043.
12. Umemura, A., A. P. Monaco, and T. Maki. 2000. Donor MHC class II antigen is essential for induction of transplantation tolerance by bone marrow cells. J. Immunol. 164:4452.
13. Umemura, A., A. P. Monaco, and T. Maki. 2001. Expression of MHC class II antigen is essential in tolerance induction by donor bone marrow cell in antilymphocyte serum-treated and rapamycin-treated mice. Transplant. Proc. 33:148.
14. Ildstad, S. T., and D. H. Sachs. 1984. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 307:168.
15. Billingham, R. E. 1961. Free Skin Grafting in Mammals. Wistar Institute Press. Philadephia. pp. 1-26.
16. Hoffman, R. A., J. M. Langrehr, T. R. Billiar, R. D. Curran, and R. L. Simmons. 1990. Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. J. Immunol. 145:2220.
17. +, and γδ-TCR cells in the recipient hematopoietic environment mediate resistance to engraftment of allogeneic donor bone marrow. J. Immunol. 168:1636.
18. Abe, R., O. Kanagawa, M. A. Sheard, B. Malissen, and M. Foo-Phillips. 1991. Characterization of a new minor lymphocyte stimulatory system. I. Cluster of self antigens recognized by "I-E reactive" Vβs, Vβ5, Vβ11, and Vβ12 T cell receptors for antigen. J. Immunol. 147:739.
19. + T cells. Immunogenetics 33:157.
20. Bill, J., O. Kanagawa, D. L. Woodland, and E. Palmer. 1989. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11-bearing T cells. J. Exp. Med. 169:1405.
21. Wekerle, T., J. Kurtz, M. Sayegh, H. Ito, A. Wells, S. Bensinger, J. Shaffer, L. Turka, and M. Sykes. 2001. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J. Immunol. 166:2311.
22. Wekerle, T., M. H. Sayegh, J. Hill, Y. Zhao, A. Chandraker, K. G. Swenson, G. Zhao, and M. Sykes. 1998. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J. Exp. Med. 187:2037.
23. Colson, Y. L., J. Lange, K. J. Fowler, and S. T. Ildstad. 1996. Mechanism for cotolerance in nonlethally conditioned mixed chimeras: negative selection of the VB T-cell receptor repertoire by both host and donor bone marrow-derived cells. Blood 88:4601.
24. Ceredig, R., and T. Rolink. 2002. A positive look at double-negative thymocytes. Nat. Rev. Immunol. 2:888.
25. - medullary thymocytes. Shi Yan. Sheng Wu Xue. Bao. 32:141.
26. Cobbold, S. P., G. Martin, S. Qin, and H. Waldmann. 1986. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323:164.
27. Sharabi, Y. and D. H. Sachs. 1989. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J. Exp. Med. 169:493.
28. + T cells play a norredundant role in the rejection of heart allografts in mice. Surgery 126:121.
29. Down, J. D., N. J. Tarbell, H. D. Thames, and P. M. Mauch. 1991. Syngeneic and allogeneic bone marrow engraftment after total body irradiation: dependence on dose, dose rate, and fractionation. Blood 77:661.
30. Ichikawa, T., E. Nakayama, A. Uenaka, M. Monden, J. Okamura, and T. Mori. 1987. Effect of Lyt-2 mAb on murine skin graft survivals. Transplant. Proc. 19:579.
31. + T cells in vivo. J. Exp. Med. 173:1463.
32. Min, W. P., D. Zhou, T. E. Ichim, G. H. Strejan, X. Xia, J. Yang, X. Huang, B. Garcia, D. White, P. Dutartre, et al. 2003. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J. Immunol. 170:1304.
33. Lubaroff, D. M., and W. K. Silvers. 1973. The importance of chimerism in maintaining tolerance of skin allografts in mice. J. Exp. Med. 111:65.
34. Morrissey, P. J., S. O. Sharrow, Y. Kohno, J. A. Berzofsky, and A. Singer. 1985. Correlation of intrathymic tolerance with intrathymic chimerism in neonatally tolerized mice. Transplantation 40:68.
35. Starzl, T. E., A. J. Demetris, N. Murase, S. T. Ildstad, C. Ricordi, and M. Trucco, 1992. Cell migration, chimerism and graft acceptance. Lancet 339:1579.
36. Starzl, T. E., M. Trucco, A. Zeevi, M. Kocova, S. T. Ildstad, A. J. Demetris, H. Ramos, W. A. Rudert, C. Ricordi, and N. Murase. 1992. Systemic chimerism in human female recipients of male livers. Lancet 340:876.
37. Fuchimoto, Y., K. Yamada, A. Shimizu, A. Yasumoto, T. Sawada, C. H. Huang, and D. H. Sachs. 1999. Relationship between chimerism and tolerance in a kidney transplantation model. J. Immunol. 162:5704.
38. Monaco, A. P., T. Maki, D. A. Hale, A. Umemura, and H. Morita. 2001. The enigma of tolerance and chimerism: variable role of T cells and chimerism in induction of tolerance with bone marrow. Transplant. Proc. 33:3837.
39. Tomita, Y., A. Khan, and M. Sykes. 1994. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen. J. Immunol. 153:1087.
40. Kraus, A. B., J. Shaffer, H. C. Toh, F. Preffer, D. Dombkowski, S. Saidman, C. Colby, R. George, S. McAfee, R. Sackstein, et al. 2003. Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. Exp. Hematol. 31:609.
41. Hale, D. A., R. Gottschalk, A. Umemura, T. Maki, and A. P. Monaco. 2000. Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation. Transplantation 69:1242.
42. Umemura, A., A. P. Monaco, and T. Maki. 2000. Donor T cells are not required for induction of allograft tolerance in mice treated with antilymphocyte serum, rapamycin, and donor bone marrow cells. Transplantation 70:1005.