Transplantation tolerance induced by 'mega dose' CD34+ cell transplants

Experimental Hematology

Volumn 28, Issue 2, 2000, Pages 119-127

  Reisner, Yair ^a   Martelli, Massimo F ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

'Mega dose'; GVHD; Haploidentical; Veto activity

Indexed keywords

CD34 ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CHILD; CLINICAL ARTICLE; HLA SYSTEM; HUMAN; IMMUNOLOGICAL TOLERANCE; NATURAL KILLER CELL; PRIORITY JOURNAL; RELAPSE; STEM CELL; T LYMPHOCYTE;

EID: 0033975675     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00132-0     Document Type: Review

References (49)

1. Thomas E.D. Marrow transplantation for malignant diseases. J Clin Oncol. 1:1983;517.
2. Kernan N.A., Bartsch G., Ash R.C., Beatty P.G., Champlin R., Filipovich A., Gajewsky J., Hansen J.A., Henslee-Downey J., McCullough J., McGlave P., Perkins H.A., Phillips G.L., Sanders J., Stroncek D., Thomas E.D., Blume K.G. Analysis of 462 transplantations from unrelated donors facilitated by the national marrow donor program. N Engl J Med. 328:1993;593.
3. Champlin R. Bone marrow transplantation for leukemia utilizing HLA-matched unrelated donors. Bone Marrow Transplant. 1(Suppl.):1995;74.
4. Anasetti E., Etzioni R., Petersdorf E.W., Martin P.J., Hansen J.A. Marrow transplantation from unrelated volunteer donors. Ann Rev Med. 46:1995;169.
5. Beatty P.G., Mori M., Milford E. Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor. Transplantation. 60:1995;778.
6. Reisner Y., Ben-Bassat I., Douer D., Kaploon A., Schwartz E., Ramot B. Demonstration of clonable alloreactive host T cells in a primate model for bone marrow transplantation. Proc Natl Acad Sci U S A. 83:1986;4012.
7. Lee L.A., Sergio J.J., Sykes M. Natural killer cells weakly resist engraftment of allogeneic long-term multilineage-repopulating hematopoietic stem cells. Transplantation. 61:1996;125.
8. Ruggeri L., Capanni M., Casucci M., Volpi I., Tosti A., Perruccio K., Urbani E., Negrin R.S., Martelli M.F., Velardi A. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood. 94:1999;333.
9. Anasetti C., Amos D., Beatty P.G., Appelbaum F.R., Besinger W., Buckner C.D., Clift R., Doney K., Martin P.J., Mickelson E., Nisperos B.B., O'Quigley J., Romberg R., Sanders J.E., Stewart P., Storb R., Sullivan K.M., Witherspoon R.P., Thomas E.D., Hansen J.A. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med. 320:1989;197.
10. Beatty P.G., Clift R.A., Mickelson E.M., Nisperos B.B., Flournoy N., Martin P.J., Sanders J.E., Stewart P., Buckner C.D., Strob R., Thomas E.D., Hanse J.A. Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med. 313:1985;765.
11. Kernan N.A., Flomenberg N., Dupont B., O'Reilly R.J. Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia. Identification of host-derived antidonor allocytotoxic T lymphocytes. Transplantation. 43:1987;842.
12. Soiffer R.J., Mauch P., Tarbell N.J., Anderson K.C., Freedman A.S., Rabinowe S.N., Takvorian T., Murrey C.I., Coral F., Bosserman L., Dear K., Nadler L.M., Ritz J. Total lymphoid irradiation to prevent graft rejection in recipients of HLA non-identical T cell-depleted allogeneic marrow. Bone Marrow Transplant. 7:1991;23.
13. Gale R.P., Reisner Y. Graft rejection and graft-versus-host disease. mirror images Lancet. 1:1986;1468.
14. Martin P.J. The role of donor lymphoid cells in allogeneic marrow engraftment. Bone Marrow Transplant. 6:1990;283.
15. Butturini A., Seeger R.C., Gale R.P. Recipient immune competent T lymphocytes can survive intensive conditioning for bone marrow transplantation. Blood. 68:1986;954.
16. Schwartz E., Lapidot T., Gozes D., Singer T.S., Reisner Y. Abrogation of bone marrow allograft resistance in mice by increased total body irradiation correlates with eradication of host clonable T-cells and alloreactive cytotoxic precursors. J Immunol. 138:1987;460.
17. Salomon O., Lapidot T., Terenzi A., Lubin I., Rabi I., Reisner Y. Induction of donor-type chimerism in murine recipients of bone marrow allografts by different radiation regimens currently used in treatment of leukemia patients. Blood. 76:1990;1872.
18. Ferrara J.L., Michaelson J., Burakoff S.J., Mauch P. Engraftment following T cell-depleted bone marrow transplantation. III. Differential effects of increased total-body irradiation on semiallogeneic recipients. Transplantation. 45:1988;948.
19. Lapidot T., Singer T.S., Salomon O., Terenzi A., Schwartz E., Reisner Y. Booster irradiation to the spleen following total body irradiation. a new immunosuppressive approach for allogeneic bone marrow transplantation J Immunol. 141:1988;2619.
20. Soderling C.C., Song C.W., Blazer B.R., Vallera D.A. A correlation between conditioning and engraftment in recipients of MHC mismatched T cell-depleted murine bone marrow transplants. Immunology. 135:1985;941.
21. Cobbold S.P., Martin G., Qin S., Waldmann H. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature. 323:1986;164.
22. Lapidot T., Terenzi A., Singer T.S., Salomon O., Reisner Y. Enhancement by dimethyl myleran of donor type chimerism in murine recipients of bone marrow allografts. Blood. 73:1989;2025.
23. Terenzi A., Lubin I., Lapidot T., Salomon O., Faktorowich Y., Raby I., Martelli M.F., Reisner Y. Enhancement of T-cell depleted bone marrow allografts in mice by thiotepa. Transplantation. 50:1990;7170.
24. Lapidot T., Terenzi A., Singer T.S., Reisner Y. Size of bone marrow inoculum versus number of donor-type cells used for presensitization. a murine model for bone marrow allograft rejection in leukemia patients Blood. 70:1987;309a.
25. Uharek L., Gassmann W., Glass B., Steinmann J., Loeffler H., Mueller-Ruchholtz W. Influence of cell dose and graft-versus-host reactivity on rejection rats after allogeneic bone marrow transplantation. Blood. 79:1992;1612.
26. Bachar-Lustig E., Rachamim N., Li H.W., Lan F., Reisner Y. Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Nature Med. 1:1995;1268.
27. Aversa F., Tabilio A., Terenzi A., Velardi A., Falzetti F., Giannoni C., Iacucci R., Zei T., Martelli M.P., Gambelunghe C., Rossetti M., Caputo P., Latini P., Aristei C., Raymondi C., Reisner Y., Martelli M.F. Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood. 84:1994;3948.
28. Aversa F., Tabilio A., Velardi A., Cunningham I., Terenzi A., Falzetti F., Ruggeri L., Barbabietola G., Aristei C., Latini P., Reisner Y., Martelli M.F. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med. 339:1998;1186.
29. + peripheral stem cell transplantation in children. Blood. 92:1998;686a.
30. Thomas J.M., Carver F.M., Kasten-Jolly J., Haisch C.E., Rebellato L.M., Gross U., Vore S.J., Thomas F.T. Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation. 57:1994;101.
31. Miller R.G., Derry H. A cell population in nu/nu spleen can prevent generation of cytotoxic lymphocytes by normal spleen cells against self antigens of the nu/nu spleen. J Immunol. 122:1979;1502.
32. Rammensee H.G., Nagy Z.A., Klein J. Suppression of cell-mediated lymphocytotoxicity against minor histocompatibility antigens mediated by Lyt-1+Lyt-2+ T cells of stimulator-strain origin. Eur J Immunol. 12:1982;930.
33. Muraoka S., Miller R.G. Cells in murine fetal liver and in lymphoid colonies grown from fetal liver can suppress generation of cytotoxic T lymphocytes directed against their self antigens. J Immunol. 131:1983;45.
34. Qin S., Cobbold S.P., Pope H., Elliott J., Kioussis D., Davies J., Waldmann H. "Infectious" transplantation tolerance. Science. 259:1993;974.
35. Strober S. Natural suppressor (NS) cells, neonatal tolerance, and total lymphoid irradiation. exploring obscure relationships Annu Rev Immunol. 2:1984;219.
36. Martin P.J. Donor CD8 cells prevent allogeneic marrow graft rejection in mice. potential implications for marrow transplantation in humans J Exp Med. 178:1993;703.
37. + thymocytes. Blood. 80:1992;2406.
38. Kaufman C.L., Colson Y.L., Wren S.M., Watkins S., Simmons R.L., Ildstad S.T. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood. 84:1994;2436.
39. Pierce G.E., Watts L.M. Thy 1+ donor cells function as veto cells in the maintenance of tolerance across a major histocompatibility complex disparity in mixed-lymphoid radiation chimeras. Transplant Proc. 25:1993;331.
40. Strober S., Palathumpat V., Schwadron R., Hertel-Wulff B. Cloned natural suppressor cells prevent lethal graft-vs-host disease. J Immunol. 138:1987;699.
41. Rachamim N., Gan J., Segall H., Krauthgamer R., Marcus H., Berrrebi A., Martelli M., Reisner Y. Tolerance induction by "megadose" hematopoietic transplants. donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture Transplantation. 65:1998;1386.
42. Bennett M. Biology and genetics of hybrid resistance. Adv Immunol. 41:1987;333.
43. - bone marrow progenitor cells. synergism with non-alloreactive (host × donor)F1 T cells Blood. 94:1999;3212.
44. Uchida N., Tsukamoto A., He D., Friera A.M., Scollay R., Weissman I.L. High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. J Clin Invest. 101:1998;961.
45. - cells and nonalloreactive T cells Transplant Proc. 30:1998;4007.
46. Cavazzana Calvo M., Stephan J.L., Sarnacki S., Chevret S., Fromont C., De Coene C., Le Deist F., Guy Grand D., Fischer A. Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination. Blood. 83:1994;288.
47. Boussiotis V.A., Gribben J.G., Freeman G.J., Nadler L.M. Blockade of the CD28 co-stimulatory pathway. a means to induce tolerance Curr Opin Immunol. 6:1994;797.
48. Gribben J.G., Guinan E.C., Boussiotis V.A., Ke X.Y., Linsley L., Sieff C., Gray G.S., Freeman G.J., Nadler L.M. Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy. a method to ameliorate graft-versus-host disease and extend the donor pool Blood. 87:1996;4887.
49. Sambhara S.R., Miller R.G. Programmed cell death of T cells signaled by the T cell receptor and the a3 domain of class I MHC. Science. 252:1991;1424.