Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

Nature Communications

Volumn 6, Issue , 2015, Pages

  Capuani, Fabrizio ^a,e   Conte, Alexia ^a   Argenzio, Elisabetta ^a,f   Marchetti, Luca ^b   Priami, Corrado ^b   Polo, Simona ^a,c   Di Fiore, Pier Paolo ^a,c,d   Sigismund, Sara ^a   Ciliberto, Andrea ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF TRENTO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; CBL PROTEIN; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR; GRB2 PROTEIN, HUMAN; PROTEIN BINDING;

AMINO ACID; CANCER; CELLS AND CELL COMPONENTS; CONCENTRATION (COMPOSITION); LIGAND; OPTIMIZATION; QUANTITATIVE ANALYSIS; THRESHOLD;

ANIMAL CELL; ARTICLE; BINDING SITE; CANCER CELL; CELL SURFACE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UBIQUITINATION; 3T3 CELL LINE; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DENSITOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; DENSITOMETRY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION; GRB2 ADAPTOR PROTEIN; HELA CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; UBIQUITINATION;

EID: 84939131033     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8999     Document Type: Article

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