Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic-pituitary-adrenal axis activation

Drug and Alcohol Dependence

Volumn 154, Issue , 2015, Pages 100-104

  Reynolds, Anna R ^a,b   Saunders, Meredith A ^a,b   Brewton, Honoree' W ^a,b   Winchester, Sydney R ^a,b   Elgumati, Ibrahim S ^a,b   Prendergast, Mark A ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Dependence; Ethanol; Glucocorticoid; Hypothalamic pituitary adrenal axis; Withdrawal

Indexed keywords

11BETA (1,3 BENZODIOXOL 5 YL) 17BETA HYDROXY 17ALPHA (1 PROPYNYL)ESTRA 4,9 DIEN 3 ONE; ALCOHOL; CORTICOSTERONE; PLACEBO; 1,3 BENZODIOXOLE DERIVATIVE; GLUCOCORTICOID RECEPTOR; STEROID;

ADULT; AGGRESSION; ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DISEASE SEVERITY; DRUG EFFECT; DRUG RESPONSE; HYPOACTIVITY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGIDITY; SEDATION; ALCOHOLISM; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DRINKING BEHAVIOR; DRUG EFFECTS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; ORAL DRUG ADMINISTRATION; PSYCHOLOGY; PSYCHOSES, SUBSTANCE-INDUCED; SUBSTANCE WITHDRAWAL SYNDROME;

RATTUS;

ADMINISTRATION, ORAL; ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; BENZODIOXOLES; CORTICOSTERONE; ETHANOL; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; PSYCHOSES, SUBSTANCE-INDUCED; RATS; RECEPTORS, GLUCOCORTICOID; STEROIDS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84938996040     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2015.06.018     Document Type: Article

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