Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective

Addiction Biology

Volumn 19, Issue 1, 2014, Pages 27-36

  Cippitelli, Andrea ^a   Damadzic, Ruslan ^a   Hamelink, Carol ^b   Brunnquell, Michael ^a   Thorsell, Annika ^a   Heilig, Markus ^a   Eskay, Robert L ^a,b  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

corticosterone; ethanol; FJ B; hippocampus; mifepristone; neurodegeneration

Indexed keywords

ALCOHOL; CHOLESTEROL; CORTICOSTERONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR 2; MIFEPRISTONE; UNCLASSIFIED DRUG;

ADRENALECTOMY; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINGE DRINKING; BRAIN CELL; CELL COUNT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DENTATE GYRUS; DRUG PELLET; DRUG RECEPTOR BINDING; ENTORHINAL CORTEX; HIPPOCAMPUS; MALE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SILVER STAINING;

CORTICOSTERONE; ETHANOL; FJ-B; HIPPOCAMPUS; MIFEPRISTONE; NEURODEGENERATION;

ADRENALECTOMY; ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ALCOHOLIC INTOXICATION; ANALYSIS OF VARIANCE; ANIMALS; BINGE DRINKING; CHOLESTEROL; CORTICOSTERONE; DENTATE GYRUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG IMPLANTS; ENTORHINAL CORTEX; ETHANOL; FLUORESCEINS; HORMONE ANTAGONISTS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIFEPRISTONE; NEUROPROTECTIVE AGENTS; PITUITARY-ADRENAL SYSTEM; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; SILVER STAINING; STRESS, PHYSIOLOGICAL;

EID: 84890799895     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2012.00451.x     Document Type: Article

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