Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 12, 2008, Pages 2107-2116

  Jacquot, Catherine ^a   Croft, Adam P ^b   Prendergast, Mark A ^c   Mulholland, Patrick ^d   Shaw, Sidney G ^e   Little, Hilary J ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF KENTUCKY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Alcohol; Glucocorticoid; Memory; Withdrawal

Indexed keywords

GLUCOCORTICOID ANTAGONIST; MIFEPRISTONE;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR CHANGE; COGNITIVE DEFECT; CONTROLLED STUDY; EXCITABILITY; HABITUATION; HIPPOCAMPUS; MAZE TEST; MOUSE; NEUROTOXICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ALCOHOL DRINKING; ANIMALS; GLUCOCORTICOIDS; HORMONE ANTAGONISTS; MALE; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MIFEPRISTONE; SUBSTANCE WITHDRAWAL SYNDROME;

MUS;

EID: 57249083987     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00799.x     Document Type: Article

References (80)

1. Adinoff B, Martin PR, Bone GH, Eckhardt MJ, Roerich L (1990) Hypothalamic-pituitary adrenal axis functioning and cerebrospinal fluid corticotrophin releasing hormone and corticotropin levels in alcoholics after recent and long term abstinence. Arch Gen Psychiat 47 : 325 330.
2. Agarwal MK (1996) The antiglucocorticoid action of mifepristone. Pharmacol Ther 70 : 183 213.
3. 3H]-dexamethasone for receptors in the rat central nervous system. J Steroid Biochem 30 : 411 415.
4. Artola A, von Frijtag JC, Fermont PCJ, Gispen WH, Schrama LH, Kamal A, Spruijt BM (2006) Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment. Eur J Neurosci 23 : 261 272.
5. Bates ME, Bowdon SC, Barry D (2002) Neurocognitive impairment associated with alcohol use disorders: implications for treatment. Exp Clin Psychopharm 10 : 193 212.
6. Bernabeu R, Thiriet N, Zwiller J, Di Scala G. (2006) Lesion of the lateral entorhinal cortex amplifies odor-induced expression of c-fos, junB, and zif 268 mRNA in rat brain. Synapse 59 : 135 143.
7. Bowdon SC, Crews FT, Bates ME, Fals-Stewart W, Ambrose ML (2001) Neurotoxicity and neurocognitive impairments with alcohol and drug-use disorders: potential roles in addiction and recovery. Alc Clin Exp Res 25 : 317 321.
8. Chaouloff F, Hemar A, Manzoni O (2007) Acute stress facilitates hippocampal CA1 metabotropic glutamate receptor-dependent long-term depression. J Neurosci 27 : 7130 7135.
9. Ciesielski KT, Waldorf AV, Jung RE (1995) Anterior brain deficits in chronic alcoholism - cause or effect? J Nerv Ment Dis 83 : 756 761.
10. Cole J, Littleton JM, Little HJ (1999) Effects of repeated ethanol administration in the elevated plus maze; a simple model for conditioned abstinence behavior. Psychopharmacology 142 : 270 279.
11. Cole J, Littleton JM, Little HJ (2000) Acamprosate, but not naltrexone, inhibits conditioned abstinence behavior associated with repeated ethanol administration and exposure to a plus maze. Psychopharmacology 147 : 403 411.
12. Cook MN, Crounse M, Flaherty L (2002) Anxiety in the elevated zero maze is augmented in mice after repeated daily exposures. Behav Gen 32 : 113 118.
13. Coussens CM, Kerr DS, Abraham WC (1997) Glucocorticoid receptor activation lowers the threshold for NMDA-receptor-dependent homosynaptic long-term depression in the hippocampus through activation of voltage-dependent calcium channels. J Neurophysiol 78 : 1 9.
14. Croft AP, Little HJ (2002) Effect of chronic ethanol on repeat plus maze testing. J Psychopharmacol 16 : A55.
15. Datson NA, van der Perk J, de Kloet ER, Vreugdenhil E (2001) Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression. Eur J Neurosci 14 : 675 689.
16. Di Sclafani V, Ezekiel F, Meyerhof DJ, Mackay S, Dillon WP, Weiner MW, Fein G (1995) Brain atrophy and cognitive function in older abstinent alcoholic men. Alc Clin Exp Res 19 : 1121 1126.
17. Duka T, Townsend JM, Collier K, Stephens DN (2003) Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients. Alc Clin Exp Res 27 : 1563 1572.
18. Durand D, Carlen PL (1984) Decreased neuronal inhibition in vitro after long-term administration of ethanol. Science 224 : 1359 1361.
19. Eichenbaum H, Kuperstein M, Fagan A, Nagode J (1987) Cue-sampling and goal-approach correlates of hippocampal unit-activity in rats performing an odor-discrimination task. J Neurosci 7 : 716 732.
20. El-Bakri NK, Islam A, Zhu SW, Elhassan A, Mohammed A, Winblad B, Adem A (2004) Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: relationship to Morris water maze performance. J Cell Mol Med 8 : 537 544.
21. Elliott ME, Sapolsky RM (1993) Corticosterone impairs hippocampal neuronal calcium regulation - possible mediating mechanisms. Brain Res 602 : 84 90.
22. Errico AL, King AC, Lovallo WR, Parsons OA (2002) Cortisol dysregulation and cognitive impairment in abstinent male alcoholics. Alc Clin Exp Res 26 : 1198 1204.
23. Espejo EF (1997) Effects of weekly or daily exposure to the elevated plus maze in male mice. Behav Brain Res 87 : 233 238.
24. Farr SA, Scherrer JF, Banks WA, Flood JF, Morley JE (2005) Chronic ethanol consumption impairs learning and memory after cessation of ethanol. Alc Clin Exp Res 29 : 971 982.
25. Freeman EW, Weinstock L, Rickels K, Sondheimer SJ, Coutifaris C (1992) A placebo-controlled study of effects of oral progesterone on performance and mood. Br J Clin Pharmacol 33 : 293 298.
26. Global Status Report on Alcohol (2004) World Health Organization. Department of Mental Health and Substance Abuse, Geneva.
27. Goldstein DB, Pal N (1971) Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction. Science 172 : 288 290.
28. Green A, Davies EM, Whittington M, Little HJ, Cross AJ (1990) Action of chlormethiazole in a model of ethanol withdrawal. Psychopharmacology 102 : 239 242.
29. Halari R, Hines M, Kumari V, Mehrotra R, Wheeler M, Ng V, Sharma T (2005) Sex differences and individual differences in cognitive performance and their relationship to endogenous gonadal hormones and gonadotropins. Behav Neurosci 119 : 104 117.
30. Havel PJ, Busch BL, Curry DL, Johnson PR, Dallman MF, Stern JS (1996) Predominantly glucocorticoid actions of RU486 in young specific-pathogen free Zucker rats. American J Physiol 271 : R710 R717.
31. Hendricson AW, Miao CLA, Lippmann MJ, Morrisett RA (2002) Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression. J Pharmacol Exp Ther 301 : 938 944.
32. Hill M, Popov P, Havlikova H, Kancheva L, Vrbikova J, Kancheva R, Pouzar V, Cerny I, Starka L (2005) Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction. Steroids 70 : 515 524.
33. Ihara H, Berrios GE, London M (2000) Group and case study of the dysexecutive syndrome in alcoholism without amnesia. J Neurol Neurosurg Psychiat 68 : 731 737.
34. Itoh J, Nabeshima T, Kameyama T (1990) Utility of an elevated plus maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock. Psychopharmacology 101 : 27 33.
35. Janis GC, Devaud LL, Mitsuyama H, Morrow AL (1998) Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in male and female rats. Alc Clin Exp Res 22 : 2055 2061.
36. Joels M, Kloet R (1994) Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems. Prog Neurobiol 43 : 1 36.
37. Krugers HJ, Goltstein PM, van der Linden S, Joels M (2006) Blockade of glucocorticoid receptors rapidly restores hippocampal CA1 plasticity after exposure to chronic stress. Euro J Neurosci 23 : 3051 3055.
38. Lieber CS, DeCarli LM (1989) Liquid diet technique of ethanol administration: 1989 update. Alc Alcohol 24 : 197 211.
39. Littleton JM, Little HJ, Whittington MA (1990) Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644. Psychopharmacology 100 : 387 392.
40. Lukoyanov NV, Madeira MD, PaulaBarbosa MM (1999) Behavioral and neuroanatomical consequences of chronic ethanol intake and withdrawal. Physiol Behav 66 : 337 346.
41. Lukoyanov NV, Paula-Barbosa MM (2001) Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol. Neurosci Lett 309 : 45 48.
42. Magarinos AM, McEwen BS (1995) Stress induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience 69 : 89 98.
43. McEwen BS (2000) Effects of adverse experience for brain structure and function. Biol Psych 48 : 721 731.
44. Meddis R (1984) Statistics Using Ranks: A Unified Approach. Basil Blackwell, Oxford, New York.
45. Meyer JL, Klumpers L, Maslam S, de Kloet ER, Joels M, Lucassen PJ (2006) Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. J Neuroendocrinol 18 : 629 631.
46. Moldow RL, Beck KD, Weaver S, Servatius RJ (2005) Blockade of glucocorticoid, but not mineralocorticoid receptors prevents the persistent increase in circulating basal corticosterone concentrations following stress in the rat. Neurosci Lett 374 : 25 28.
47. Molleman A, Little HJ (1995) Increases in non-NMDA glutaminergic transmission, but no change in GABAB transmission, during withdrawal from chronic ethanol treatment. J Pharmacol Exp Ther 274 : 1035 1041.
48. Morton B, Ripley T, Whittington A, Butterworth AR, Little HJ (1992) Evidence that changes in hippocampal excitability in vitro are caused by withdrawal from chronic in vivo ethanol administration. Alc Alcohol 27 : 71 79.
49. Mulholland PJ, Self RL, Harris BR, Little HJ, Littleton JM, Prendergast MA (2005) Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures. Alc Clin Exp Res 29 : 871 881.
50. Newcomer JW, Selke G, Melson AK, Hershey T, Craft S, Richards K, Alderson AL (1999) Decreased memory performance in healthy humans induced by stress level cortisol treatment. Arch Gen Psychiat 56 : 527 533.
51. Noel X, Van der Linden M, Schmidt N, Sferrazza R, Hanak C, Le Bon O, De Mol J, Kornreich C, Pelc I, Verbanck P (2001) Supervisory attentional system in nonamnesic alcoholic men. Arch Gen Psychiat 58 : 1152 1158.
52. Roberto M, Nelson TE, Ur CL, Gruol DL (2002) Long-term potentiation in the rat hippocampus is reversibly depressed by chronic ethanol exposure. J Neurophys 87 : 2385 2396.
53. Roberts AJ, Crabbe JC, Keith LD (1992) Genetic differences in hypothalamic pituitary-adrenal axis responsiveness to acute ethanol and acute ethanol withdrawal. Brain Res 579 : 296 302.
54. Rodgers RJ, Lee C, Shepherd JK (1992) Effects of diazepam on behavioural and antinociceptive responses to the elevated plus maze in male mice depend upon treatment regimen and prior maze experience. Psychopharmacology 106 : 102 110.
55. Rodgers RJ, Shepherd JK (1993) Influence of prior maze experience on behaviour and response to diazepam in the elevated plus maze and light/dark tests of anxiety in mice. Psychopharmacology 113 : 237 242.
56. Sapolsky RM (1986) The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocrinol Rev 7 : 284 301.
57. Sapolsky RM (1996a) Why stress is bad for your brain. Science 273 : 749 750.
58. Sapolsky RM (1996b) Stress, glucocorticoids and damage to the nervous system: the current state of confusion. Stress 1 : 1 19.
59. Sapolsky RM (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiat 57 : 925 935.
60. Sarkar NN (2002) Mifepristone: bioavailability, pharmacokinetics and use-effectiveness. Eur J Obst Gyn 101 : 113 120.
61. Schandler SL, Clegg AD, Thomas CS, Cohen MJ (1996) Visuospatial information processing in intoxicated, recently detoxified, and long-term abstinent alcoholics. J Subst Abuse 8 : 321 333.
62. Shear DA, Galani R, Hoffman SW, Stein DG. (2002) Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury. Exp Neurol 178 : 59 67.
63. Sitruk-Ware R, Spiz IM (2003) Pharmacological properties of mifepristone: toxicology and safety in animal and human studies. Contraception 68 : 409 420.
64. Sullivan EV, Fama R, Rosenbloom MJ, Pfefferbaum A (2002) A profile of neuropsychological deficits in alcoholic women. Neuropsychology 16 : 74 83.
65. Sullivan EV, Rosenbloom MJ, Pfefferbaum A (2000) Pattern of motor and cognitive deficits in detoxified alcoholic men. Alc Clin Exp Res 24 : 611 621.
66. Tabakoff B, Jaffe RC, Ritzmann RF (1978) Corticosterone concentrations in mice during ethanol drinking and withdrawal. J Pharm Pharmacol 30 : 371 374.
67. Thinschmidt JS, Walker DW, King MA (2003) Chronic ethanol treatment reduces the magnitude of hippocampal LTD in the adult rat. Synapse 48 : 189 197.
68. Tremwel MF, Hunter BE (1994) Effects of chronic ethanol ingestion on long-term potentiation remain even after a prolonged recovery from ethanol exposure. Synapse 17 : 141 148.
69. Uekermann J, Daum I, Schlebusch P, Wiebel B, Trenckmann U (2003) Depression and cognitive functioning in alcoholism. Addiction 98 : 1521 1529.
70. Voltaire-Carlsson A, Hiltonen AJ, Koechling UM, Borg S (1996) Effects of long term abstinence on psychological functioning: a prospective longitudinal analysis comparing alcohol-dependent patients and healthy volunteers. Alcohol 13 : 415 421.
71. Vreugdenhil E, de Kloet ER, Schaaf M, Datson NA (2001) Genetic dissection of corticosterone receptor function in the rat hippocampus. Eur Neuropsychopharmacol 11 : 423 430.
72. Watanabe K-I, Ogihara-Hashizume A, Kobayashi Y, Mitsushio H, Komiyama T (2001) Impaired sleep during the post-alcohol withdrawal period in alcoholic patients. Addict Biol 6 : 163 169.
73. Watson WP, Little HJ (2002) Selectivity of the effects of dihydropyridine calcium channel antagonists against the alcohol withdrawal syndrome. Brain Res 930 : 111 122.
74. Whittington MA, Dolin SJ, Patch TL, Siarey RJ, Butterworth AR, Little HJ (1991) Chronic dihydropyridine treatment can reverse the behavioral consequences of and prevent the adaptations to, chronic ethanol treatment. Br J Pharmacol 103 : 1669 1676.
75. Whittington MA, Lambert JDC, Little HJ (1995) Increased NMDA-receptor and calcium channel activity during ethanol withdrawal hyperexcitability. Alc Alcohol 30 : 105 114.
76. Winters BD, Bussey TJ (2005) Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat. Eur J Neurosci 21 : 2263 2270.
77. Xia JX, Li J, Zhou R, Zhang XH, Ge YB, Yuan XR (2006) Alterations of rat corticostriatal synaptic plasticity after chronic ethanol exposure and withdrawal. Alc Clin Exp Res 30 : 819 824.
78. Yang CH, Huang CC, Hsu KS (2004) Behavioral stress modifies hippocampal synaptic plasticity through corticosterone-induced sustained extracellular signal-regulated kinase/mitogen-activated protein kinase activation. J Neurosci 24 : 11029 11034.
79. Young AH, Gallagher P, Watson S, Del-Estal D, Owen BM, Ferrier IN (2004) Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacol 29 : 1538 1545.
80. Zhang XL, Begleiter H, Porjesz B (1997) Electrophysiological evidence of memory impairment in alcoholic patients. Biol Psychiat 42 : 1157 1171.