메뉴 건너뛰기




Volumn 88, Issue 3, 2015, Pages 213-219

Pancreatic cancer genomics: Where can the science take us?

Author keywords

Genomics; Next generation sequencing; Pancreatic cancer; Stratified medicine; Translational medicine

Indexed keywords

BIOLOGICAL MARKER; CAPECITABINE; ERLOTINIB; FLUOROURACIL; GEMCITABINE; IRINOTECAN; OXALIPLATIN; PACLITAXEL; ANTINEOPLASTIC AGENT;

EID: 84938991200     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/cge.12536     Document Type: Review
Times cited : (13)

References (41)
  • 1
    • 84902147062 scopus 로고    scopus 로고
    • Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States
    • Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 2014: 74 (11): 2913-2921.
    • (2014) Cancer Res , vol.74 , Issue.11 , pp. 2913-2921
    • Rahib, L.1    Smith, B.D.2    Aizenberg, R.3    Rosenzweig, A.B.4    Fleshman, J.M.5    Matrisian, L.M.6
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997: 15 (6): 2403-2413.
    • (1997) J Clin Oncol , vol.15 , Issue.6 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 3
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007: 25 (15): 1960-1966.
    • (2007) J Clin Oncol , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 4
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken DD et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 2009: 27 (33): 5513-5518.
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3
  • 5
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011: 364 (19): 1817-1825.
    • (2011) N Engl J Med , vol.364 , Issue.19 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 6
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • Von Hoff DD, Ervin T, Arena FP et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013: 369 (18): 1691-1703.
    • (2013) N Engl J Med , vol.369 , Issue.18 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3
  • 7
    • 34247252488 scopus 로고    scopus 로고
    • Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy
    • Sultana A, Tudur Smith C, Cunningham D et al. Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. Br J Cancer 2007: 96 (8): 1183-1190.
    • (2007) Br J Cancer , vol.96 , Issue.8 , pp. 1183-1190
    • Sultana, A.1    Tudur Smith, C.2    Cunningham, D.3
  • 8
    • 84902932005 scopus 로고    scopus 로고
    • Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis
    • Gresham GK, Wells GA, Gill S, Cameron C, Jonker DJ. Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis. BMC Cancer 2014: 14 (1): 471.
    • (2014) BMC Cancer , vol.14 , Issue.1 , pp. 471
    • Gresham, G.K.1    Wells, G.A.2    Gill, S.3    Cameron, C.4    Jonker, D.J.5
  • 9
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • Hudson TJ, Anderson W, Artez A et al. International network of cancer genome projects. Nature 2010: 464 (7291): 993-998.
    • (2010) Nature , vol.464 , Issue.7291 , pp. 993-998
    • Hudson, T.J.1    Anderson, W.2    Artez, A.3
  • 10
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008: 321 (5897): 1801-1806.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 11
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell PJ, Yachida S, Mudie LJ et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 2010: 467 (7319): 1109-1113.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1109-1113
    • Campbell, P.J.1    Yachida, S.2    Mudie, L.J.3
  • 12
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010: 467 (7319): 1114-1117.
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 13
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin AV, Waddell N, Kassahn KS et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012: 491 (7424): 399-405.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 399-405
    • Biankin, A.V.1    Waddell, N.2    Kassahn, K.S.3
  • 14
    • 84866700697 scopus 로고    scopus 로고
    • qpure: a tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles
    • Song S, Nones K, Miller D et al. qpure: a tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles. PLoS One 2012: 7 (9): e45835.
    • (2012) PLoS One , vol.7 , Issue.9 , pp. e45835
    • Song, S.1    Nones, K.2    Miller, D.3
  • 15
    • 84859947197 scopus 로고    scopus 로고
    • Sleeping beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • Mann KM, Ward JM, Yew CC et al. Sleeping beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A 2012: 109 (16): 5934-5941.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.16 , pp. 5934-5941
    • Mann, K.M.1    Ward, J.M.2    Yew, C.C.3
  • 16
    • 84861990162 scopus 로고    scopus 로고
    • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
    • Perez-Mancera PA, Rust AG, van der Weyden L et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 2012: 486 (7402): 266-270.
    • (2012) Nature , vol.486 , Issue.7402 , pp. 266-270
    • Perez-Mancera, P.A.1    Rust, A.G.2    van der Weyden, L.3
  • 17
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
    • Cheung HW, Cowley GS, Weir BA et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A 2011: 108 (30): 12372-12377.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.30 , pp. 12372-12377
    • Cheung, H.W.1    Cowley, G.S.2    Weir, B.A.3
  • 18
    • 84856955522 scopus 로고    scopus 로고
    • The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
    • Samuel N, Hudson TJ. The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma. Nat Rev Gastroenterol Hepatol 2012: 9 (2): 77-87.
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , Issue.2 , pp. 77-87
    • Samuel, N.1    Hudson, T.J.2
  • 19
    • 84887425166 scopus 로고    scopus 로고
    • Evolution and dynamics of pancreatic cancer progression
    • Yachida S, Iacobuzio-Donahue CA. Evolution and dynamics of pancreatic cancer progression. Oncogene 2013: 32 (45): 5253-5260.
    • (2013) Oncogene , vol.32 , Issue.45 , pp. 5253-5260
    • Yachida, S.1    Iacobuzio-Donahue, C.A.2
  • 20
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC et al. Signatures of mutational processes in human cancer. Nature 2013: 500 (7463): 415-421.
    • (2013) Nature , vol.500 , Issue.7463 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 21
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
    • Von Hoff DD, Stephenson JJ Jr, Rosen P et al. Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol 2010: 28 (33): 4877-4883.
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4877-4883
    • Von Hoff, D.D.1    Stephenson Jr, J.J.2    Rosen, P.3
  • 22
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • Farrell JJ, Elsaleh H, Garcia M et al. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2009: 136 (1): 187-195.
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 187-195
    • Farrell, J.J.1    Elsaleh, H.2    Garcia, M.3
  • 23
    • 84880064241 scopus 로고    scopus 로고
    • HENT1 tumor levels to predict survival of pancreatic ductal adenocarcinoma patients who received adjuvant gemcitabine and adjuvant 5FU on the ESPAC trials
    • Neoptolemos J, Greenhalf W, Ghaneh P, Palmer D, Cox T, Garner E. HENT1 tumor levels to predict survival of pancreatic ductal adenocarcinoma patients who received adjuvant gemcitabine and adjuvant 5FU on the ESPAC trials. J Clin Oncol 2013: 31.
    • (2013) J Clin Oncol , vol.31
    • Neoptolemos, J.1    Greenhalf, W.2    Ghaneh, P.3    Palmer, D.4    Cox, T.5    Garner, E.6
  • 24
    • 84905183085 scopus 로고    scopus 로고
    • Hent1 expression in patients with pancreatic cancer treated with gemcitabine after curative intended resection: Results from the CONKO-001 trial
    • Sinn M, Sinn B, Stieler J et al. Hent1 expression in patients with pancreatic cancer treated with gemcitabine after curative intended resection: Results from the CONKO-001 trial. J Clin Oncol 2014: 32: 5s.
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Sinn, M.1    Sinn, B.2    Stieler, J.3
  • 25
    • 84892633020 scopus 로고    scopus 로고
    • Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial
    • Greenhalf W, Ghaneh P, Neoptolemos JP, et al. Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. J Natl Cancer Inst 2014: 106 (1): djt347.
    • (2014) J Natl Cancer Inst , vol.106 , Issue.1
    • Greenhalf, W.1    Ghaneh, P.2    Neoptolemos, J.P.3
  • 26
    • 84902258164 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 is not predictive for gemcitabine efficacy in advanced pancreatic cancer: translational results from the AIO-PK0104 phase III study with the clone SP120 rabbit antibody
    • Ormanns S, Heinemann V, Raponi M et al. Human equilibrative nucleoside transporter 1 is not predictive for gemcitabine efficacy in advanced pancreatic cancer: translational results from the AIO-PK0104 phase III study with the clone SP120 rabbit antibody. Eur J Cancer 2014: 50 (11): 1891-1899.
    • (2014) Eur J Cancer , vol.50 , Issue.11 , pp. 1891-1899
    • Ormanns, S.1    Heinemann, V.2    Raponi, M.3
  • 27
    • 73949155519 scopus 로고    scopus 로고
    • Changing the paradigm in conducting randomized clinical studies in advanced pancreatic cancer: an opportunity for better clinical development
    • Tabernero J, Macarulla T. Changing the paradigm in conducting randomized clinical studies in advanced pancreatic cancer: an opportunity for better clinical development. J Clin Oncol 2009: 27 (33): 5487-5491.
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5487-5491
    • Tabernero, J.1    Macarulla, T.2
  • 28
    • 84872677684 scopus 로고    scopus 로고
    • Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials
    • Ciliberto D, Botta C, Correale P et al. Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials. Eur J Cancer 2013: 49 (3): 593-603.
    • (2013) Eur J Cancer , vol.49 , Issue.3 , pp. 593-603
    • Ciliberto, D.1    Botta, C.2    Correale, P.3
  • 29
    • 67349284098 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
    • Byrski T, Huzarski T, Dent R et al. Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2009: 115 (2): 359-363.
    • (2009) Breast Cancer Res Treat , vol.115 , Issue.2 , pp. 359-363
    • Byrski, T.1    Huzarski, T.2    Dent, R.3
  • 30
    • 77952494240 scopus 로고    scopus 로고
    • BRCA1 as a therapeutic target in sporadic epithelial ovarian cancer
    • Clark-Knowles KV, O'Brien AM, Weberpals JI. BRCA1 as a therapeutic target in sporadic epithelial ovarian cancer. J Oncol 2010: 2010: 891059.
    • (2010) J Oncol , vol.2010 , pp. 891059
    • Clark-Knowles, K.V.1    O'Brien, A.M.2    Weberpals, J.I.3
  • 32
    • 33846916208 scopus 로고    scopus 로고
    • Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    • Infante JR, Matsubayashi H, Sato N et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol 2007: 25 (3): 319-325.
    • (2007) J Clin Oncol , vol.25 , Issue.3 , pp. 319-325
    • Infante, J.R.1    Matsubayashi, H.2    Sato, N.3
  • 33
    • 77958171910 scopus 로고    scopus 로고
    • Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma
    • Mantoni TS, Schendel RR, Rodel F et al. Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol Ther 2008: 7 (11): 1806-1815.
    • (2008) Cancer Biol Ther , vol.7 , Issue.11 , pp. 1806-1815
    • Mantoni, T.S.1    Schendel, R.R.2    Rodel, F.3
  • 34
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial
    • Von Hoff DD, Ramanathan RK, Borad MJ et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol 2011: 29 (34): 4548-4554.
    • (2011) J Clin Oncol , vol.29 , Issue.34 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3
  • 35
    • 84928389785 scopus 로고    scopus 로고
    • O-0004SPARC analysis in the phase III MPACT trial of nab-paclitaxel (NAB-P) plus gemcitabine (GEM) vs gem alone for patients with metastatic pancreatic cancer (PC)
    • Hidalgo M, Plaza C, Illei P et al. O-0004SPARC analysis in the phase III MPACT trial of nab-paclitaxel (NAB-P) plus gemcitabine (GEM) vs gem alone for patients with metastatic pancreatic cancer (PC). Ann Oncol 2014: 25 (Suppl 2): ii106.
    • (2014) Ann Oncol , vol.25 , pp. ii106
    • Hidalgo, M.1    Plaza, C.2    Illei, P.3
  • 36
    • 84909636274 scopus 로고    scopus 로고
    • SPARC expression in resected pancreatic cancer patients treated with gemcitabine: results from the CONKO-001 study
    • Sinn M, Sinn BV, Striefler JK et al. SPARC expression in resected pancreatic cancer patients treated with gemcitabine: results from the CONKO-001 study. Ann Oncol 2014: 25 (5): 1025-1032.
    • (2014) Ann Oncol , vol.25 , Issue.5 , pp. 1025-1032
    • Sinn, M.1    Sinn, B.V.2    Striefler, J.K.3
  • 37
    • 78650095716 scopus 로고    scopus 로고
    • Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3
    • da Cunha SG, Dhani N, Tu D et al. Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3. Cancer 2010: 116 (24): 5599-5607.
    • (2010) Cancer , vol.116 , Issue.24 , pp. 5599-5607
    • da Cunha, S.G.1    Dhani, N.2    Tu, D.3
  • 38
    • 84903729284 scopus 로고    scopus 로고
    • Phase II, randomized, biomarker identification trial (MARK) for erlotinib in patients with advanced pancreatic carcinoma
    • Propper D, Davidenko I, Bridgewater J et al. Phase II, randomized, biomarker identification trial (MARK) for erlotinib in patients with advanced pancreatic carcinoma. Ann Oncol 2014: 25 (7): 1384-1390.
    • (2014) Ann Oncol , vol.25 , Issue.7 , pp. 1384-1390
    • Propper, D.1    Davidenko, I.2    Bridgewater, J.3
  • 39
    • 84894477310 scopus 로고    scopus 로고
    • Evaluating many treatments and biomarkers in oncology: a new design
    • Kaplan R, Maughan T, Crook A et al. Evaluating many treatments and biomarkers in oncology: a new design. J Clin Oncol 2013: 31 (36): 4562-4568.
    • (2013) J Clin Oncol , vol.31 , Issue.36 , pp. 4562-4568
    • Kaplan, R.1    Maughan, T.2    Crook, A.3
  • 40
    • 84862800800 scopus 로고    scopus 로고
    • Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial
    • James ND, Sydes MR, Mason MD et al. Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial. Lancet Oncol 2012: 13 (5): 549-558.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 549-558
    • James, N.D.1    Sydes, M.R.2    Mason, M.D.3
  • 41
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early- and late-stage human malignancies
    • 224ra24
    • Bettegowda C, Sausen M, Leary RJ et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014: 6 (224): 224ra24.
    • (2014) Sci Transl Med. , vol.6 , Issue.224
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.