Dual function of the IRF8 transcription factor in autoimmune uveitis: Loss of IRF8 in T cells exacerbates uveitis, whereas Irf8 deletion in the retina confers protection

Journal of Immunology

Volumn 195, Issue 4, 2015, Pages 1480-1488

  Kim, Sung Hye ^a   Burton, Jenna ^a   Yu, Cheng Rong ^a   Sun, Lin ^a   He, Chang ^a   Wang, Hongsheng ^b   Morse, Herbert C ^b   Egwuagu, Charles E ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; AUTACOID; CYTOKINE; INTERFERON REGULATORY FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE UVEITIS; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REGULATORY T LYMPHOCYTE; RETINA CELL; TH17 CELL; TISSUE SPECIFICITY; UPREGULATION; ANIMAL; AUTOIMMUNE DISEASES; DEFICIENCY; DISEASE MODEL; ELECTRORETINOGRAPHY; GENE DELETION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RETINA; RETINA NERVE CELL; SEVERITY OF ILLNESS INDEX; T LYMPHOCYTE SUBPOPULATION; UVEITIS;

ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; GENE DELETION; INFLAMMATION MEDIATORS; INTERFERON REGULATORY FACTORS; MICE; MICE, KNOCKOUT; MICROGLIA; RETINA; RETINAL NEURONS; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTE SUBSETS; TH17 CELLS; UVEITIS;

EID: 84938940411     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500653     Document Type: Article

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