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Volumn 195, Issue 4, 2015, Pages 1489-1497

Peripherally induced tolerance depends on peripheral regulatory T cells that require hopx to inhibit intrinsic IL-2 expression

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CELL PROTEIN; HOMEODOMAIN ONLY PROTEIN; INTERLEUKIN 2; UNCLASSIFIED DRUG; HOD PROTEIN, MOUSE; HOMEODOMAIN PROTEIN;

EID: 84938912403     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500174     Document Type: Article
Times cited : (38)

References (71)
  • 2
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
    • Curotto de Lafaille, M.A., and J. J. Lafaille. 2009. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30: 626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto De Lafaille, M.A.1    Lafaille, J.J.2
  • 3
    • 67649138829 scopus 로고    scopus 로고
    • Regulatory T cells in the control of hostmicroorganism interactions (∗)
    • Belkaid, Y., and K. Tarbell. 2009. Regulatory T cells in the control of hostmicroorganism interactions (∗). Annu. Rev. Immunol. 27: 551-589.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 551-589
    • Belkaid, Y.1    Tarbell, K.2
  • 4
    • 74049110516 scopus 로고    scopus 로고
    • Checkpoints in lymphocyte development and autoimmune disease
    • von Boehmer, H., and F. Melchers. 2010. Checkpoints in lymphocyte development and autoimmune disease. Nat. Immunol. 11: 14-20.
    • (2010) Nat. Immunol. , vol.11 , pp. 14-20
    • Von Boehmer, H.1    Melchers, F.2
  • 5
    • 84859390119 scopus 로고    scopus 로고
    • Induced CD4+Foxp3+ regulatory T cells in immune tolerance
    • Bilate, A. M., and J. J. Lafaille. 2012. Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu. Rev. Immunol. 30: 733-758.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 733-758
    • Bilate, A.M.1    Lafaille, J.J.2
  • 6
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz, S. Z., L. F. Lu, and A. Y. Rudensky. 2012. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30: 531-564.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 8
    • 84888872209 scopus 로고    scopus 로고
    • Controlling the frontier: Regulatory T-cells and intestinal homeostasis
    • Bollrath, J., and F. M. Powrie. 2013. Controlling the frontier: regulatory T-cells and intestinal homeostasis. Semin. Immunol. 25: 352-357.
    • (2013) Semin. Immunol. , vol.25 , pp. 352-357
    • Bollrath, J.1    Powrie, F.M.2
  • 9
    • 0018414685 scopus 로고
    • The induction of cellmediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells
    • Miller, S. D., R. P. Wetzig, and H. N. Claman. 1979. The induction of cellmediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells. J. Exp. Med. 149: 758-773.
    • (1979) J. Exp. Med. , vol.149 , pp. 758-773
    • Miller, S.D.1    Wetzig, R.P.2    Claman, H.N.3
  • 13
    • 33846919872 scopus 로고    scopus 로고
    • Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis
    • Turley, D. M., and S. D. Miller. 2007. Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis. J. Immunol. 178: 2212-2220.
    • (2007) J. Immunol. , vol.178 , pp. 2212-2220
    • Turley, D.M.1    Miller, S.D.2
  • 14
    • 47249146866 scopus 로고    scopus 로고
    • Induction of anergy by antibody blockade of TCR in myelin oligodendrocyte glycoprotein-specific cells
    • Wasserman, H. A., and B. D. Evavold. 2008. Induction of anergy by antibody blockade of TCR in myelin oligodendrocyte glycoprotein-specific cells. J. Immunol. 180: 7259-7264.
    • (2008) J. Immunol. , vol.180 , pp. 7259-7264
    • Wasserman, H.A.1    Evavold, B.D.2
  • 15
    • 80052670800 scopus 로고    scopus 로고
    • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells
    • Getts, D. R., D. M. Turley, C. E. Smith, C. T. Harp, D. McCarthy, E. M. Feeney, M. T. Getts, A. J. Martin, X. Luo, R. L. Terry, et al. 2011. Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. J. Immunol. 187: 2405-2417.
    • (2011) J. Immunol. , vol.187 , pp. 2405-2417
    • Getts, D.R.1    Turley, D.M.2    Smith, C.E.3    Harp, C.T.4    McCarthy, D.5    Feeney, E.M.6    Getts, M.T.7    Martin, A.J.8    Luo, X.9    Terry, R.L.10
  • 16
    • 77953633327 scopus 로고    scopus 로고
    • TGF-betainduced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis
    • Zhang, H., J. R. Podojil, J. Chang, X. Luo, and S. D. Miller. 2010. TGF-betainduced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis. J. Immunol. 184: 6629-6636.
    • (2010) J. Immunol. , vol.184 , pp. 6629-6636
    • Zhang, H.1    Podojil, J.R.2    Chang, J.3    Luo, X.4    Miller, S.D.5
  • 23
    • 84884216197 scopus 로고    scopus 로고
    • Targeting of autoantigens to DEC205+ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice
    • Ring, S., M. Maas, D. M. Nettelbeck, A. H. Enk, and K. Mahnke. 2013. Targeting of autoantigens to DEC205+ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice. J. Immunol. 191: 2938-2947.
    • (2013) J. Immunol. , vol.191 , pp. 2938-2947
    • Ring, S.1    Maas, M.2    Nettelbeck, D.M.3    Enk, A.H.4    Mahnke, K.5
  • 24
    • 84886728752 scopus 로고    scopus 로고
    • IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    • Mascanfroni, I. D., A. Yeste, S. M. Vieira, E. J. Burns, B. Patel, I. Sloma, Y. Wu, L. Mayo, R. Ben-Hamo, S. Efroni, et al. 2013. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat. Immunol. 14: 1054-1063.
    • (2013) Nat. Immunol. , vol.14 , pp. 1054-1063
    • Mascanfroni, I.D.1    Yeste, A.2    Vieira, S.M.3    Burns, E.J.4    Patel, B.5    Sloma, I.6    Wu, Y.7    Mayo, L.8    Ben-Hamo, R.9    Efroni, S.10
  • 25
    • 79954506102 scopus 로고    scopus 로고
    • Dendritic cell control of tolerogenic responses
    • Manicassamy, S., and B. Pulendran. 2011. Dendritic cell control of tolerogenic responses. Immunol. Rev. 241: 206-227.
    • (2011) Immunol. Rev. , vol.241 , pp. 206-227
    • Manicassamy, S.1    Pulendran, B.2
  • 27
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad, M., P. Sathe, J. Helft, J. Miller, and A. Mortha. 2013. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31: 563-604.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 28
    • 2942523789 scopus 로고    scopus 로고
    • Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo
    • Hawiger, D., R. F. Masilamani, E. Bettelli, V. K. Kuchroo, and M. C. Nussenzweig. 2004. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity 20: 695-705.
    • (2004) Immunity , vol.20 , pp. 695-705
    • Hawiger, D.1    Masilamani, R.F.2    Bettelli, E.3    Kuchroo, V.K.4    Nussenzweig, M.C.5
  • 29
    • 77956960212 scopus 로고    scopus 로고
    • The transcription cofactor Hopx is required for regulatory T cell function in dendritic cellmediated peripheral T cell unresponsiveness
    • Hawiger, D., Y. Y. Wan, E. E. Eynon, and R. A. Flavell. 2010. The transcription cofactor Hopx is required for regulatory T cell function in dendritic cellmediated peripheral T cell unresponsiveness. Nat. Immunol. 11: 962-968.
    • (2010) Nat. Immunol. , vol.11 , pp. 962-968
    • Hawiger, D.1    Wan, Y.Y.2    Eynon, E.E.3    Flavell, R.A.4
  • 31
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan, Y. Y., and R. A. Flavell. 2005. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 102: 5126-5131.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 32
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • Bettelli, E., M. Pagany, H. L. Weiner, C. Linington, R. A. Sobel, and V. K. Kuchroo. 2003. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 197: 1073-1081.
    • (2003) J. Exp. Med. , vol.197 , pp. 1073-1081
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 33
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle, H., T. Holtschke, T. Hünig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hünig, T.3    Schimpl, A.4    Horak, I.5
  • 34
    • 84875475734 scopus 로고    scopus 로고
    • Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells
    • Takeda, N., R. Jain, M. R. Leboeuf, A. Padmanabhan, Q. Wang, L. Li, M. M. Lu, S. E. Millar, and J. A. Epstein. 2013. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development 140: 1655-1664.
    • (2013) Development , vol.140 , pp. 1655-1664
    • Takeda, N.1    Jain, R.2    LeBoeuf, M.R.3    Padmanabhan, A.4    Wang, Q.5    Li, L.6    Lu, M.M.7    Millar, S.E.8    Epstein, J.A.9
  • 37
    • 0037122011 scopus 로고    scopus 로고
    • Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class i products and peripheral CD8+ T cell tolerance
    • Bonifaz, L., D. Bonnyay, K. Mahnke, M. Rivera, M. C. Nussenzweig, and R. M. Steinman. 2002. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. 196: 1627-1638.
    • (2002) J. Exp. Med. , vol.196 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 39
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta, V., C. Baecher-Allan, H. L. Weiner, and D. A. Hafler. 2004. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199: 971-979.
    • (2004) J. Exp. Med. , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 41
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • Malek, T. R., and I. Castro. 2010. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 33: 153-165.
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 43
    • 33947644716 scopus 로고    scopus 로고
    • Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson, T. S., R. J. DiPaolo, J. Andersson, and E. M. Shevach. 2007. Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J. Immunol. 178: 4022-4026.
    • (2007) J. Immunol. , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    DiPaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 44
    • 46749126890 scopus 로고    scopus 로고
    • Adaptive Foxp3+ regulatory T cell-dependent and-independent control of allergic inflammation
    • Curotto de Lafaille, M. A., N. Kutchukhidze, S. Shen, Y. Ding, H. Yee, and J. J. Lafaille. 2008. Adaptive Foxp3+ regulatory T cell-dependent and-independent control of allergic inflammation. Immunity 29: 114-126.
    • (2008) Immunity , vol.29 , pp. 114-126
    • Curotto De Lafaille, M.A.1    Kutchukhidze, N.2    Shen, S.3    Ding, Y.4    Yee, H.5    Lafaille, J.J.6
  • 46
    • 84863619688 scopus 로고    scopus 로고
    • Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict
    • Samstein, R. M., S. Z. Josefowicz, A. Arvey, P. M. Treuting, and A. Y. Rudensky. 2012. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell 150: 29-38.
    • (2012) Cell , vol.150 , pp. 29-38
    • Samstein, R.M.1    Josefowicz, S.Z.2    Arvey, A.3    Treuting, P.M.4    Rudensky, A.Y.5
  • 51
  • 52
    • 0142186685 scopus 로고    scopus 로고
    • HATs off to Hop: Recruitment of a class i histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy
    • Hamamori, Y., and M. D. Schneider. 2003. HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy. J. Clin. Invest. 112: 824-826.
    • (2003) J. Clin. Invest. , vol.112 , pp. 824-826
    • Hamamori, Y.1    Schneider, M.D.2
  • 56
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • Takeda, N., R. Jain, M. R. LeBoeuf, Q. Wang, M. M. Lu, and J. A. Epstein. 2011. Interconversion between intestinal stem cell populations in distinct niches. Science 334: 1420-1424.
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1    Jain, R.2    LeBoeuf, M.R.3    Wang, Q.4    Lu, M.M.5    Epstein, J.A.6
  • 58
    • 84878990582 scopus 로고    scopus 로고
    • Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis
    • Cheung, W. K., M. Zhao, Z. Liu, L. E. Stevens, P. D. Cao, J. E. Fang, T. F. Westbrook, and D. X. Nguyen. 2013. Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell 23: 725-738.
    • (2013) Cancer Cell , vol.23 , pp. 725-738
    • Cheung, W.K.1    Zhao, M.2    Liu, Z.3    Stevens, L.E.4    Cao, P.D.5    Fang, J.E.6    Westbrook, T.F.7    Nguyen, D.X.8
  • 59
    • 84878982799 scopus 로고    scopus 로고
    • Hopping between differentiation states in lung adenocarcinoma
    • Watanabe, H., and M. Meyerson. 2013. Hopping between differentiation states in lung adenocarcinoma. Cancer Cell 23: 707-709.
    • (2013) Cancer Cell , vol.23 , pp. 707-709
    • Watanabe, H.1    Meyerson, M.2
  • 62
    • 84872740201 scopus 로고    scopus 로고
    • Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells
    • Baine, I., S. Basu, R. Ames, R. S. Sellers, and F. Macian. 2013. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J. Immunol. 190: 1008-1016.
    • (2013) J. Immunol. , vol.190 , pp. 1008-1016
    • Baine, I.1    Basu, S.2    Ames, R.3    Sellers, R.S.4    Macian, F.5
  • 63
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton, A. M., and E. M. Shevach. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 64
    • 84872790689 scopus 로고    scopus 로고
    • Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
    • Liao, W., J. X. Lin, and W. J. Leonard. 2013. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 38: 13-25.
    • (2013) Immunity , vol.38 , pp. 13-25
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 65
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • Boyman, O., M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent. 2006. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311: 1924-1927.
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 67
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Webster, K. E., S. Walters, R. E. Kohler, T. Mrkvan, O. Boyman, C. D. Surh, S. T. Grey, and J. Sprent. 2009. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206: 751-760.
    • (2009) J. Exp. Med. , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3    Mrkvan, T.4    Boyman, O.5    Surh, C.D.6    Grey, S.T.7    Sprent, J.8
  • 68
    • 84860235383 scopus 로고    scopus 로고
    • Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation
    • Grigorian, A., H. Mkhikian, and M. Demetriou. 2012. Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation. Ann. N. Y. Acad. Sci. 1253: 49-57.
    • (2012) Ann. N. Y. Acad. Sci. , vol.1253 , pp. 49-57
    • Grigorian, A.1    Mkhikian, H.2    Demetriou, M.3
  • 69
    • 84885048272 scopus 로고    scopus 로고
    • IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells
    • Kim, M. G., T. Y. Koo, J. J. Yan, E. Lee, K. H. Han, J. C. Jeong, H. Ro, B. S. Kim, S. K. Jo, K. H. Oh, et al. 2013. IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells. J. Am. Soc. Nephrol. 24: 1529-1536.
    • (2013) J. Am. Soc. Nephrol. , vol.24 , pp. 1529-1536
    • Kim, M.G.1    Koo, T.Y.2    Yan, J.J.3    Lee, E.4    Han, K.H.5    Jeong, J.C.6    Ro, H.7    Kim, B.S.8    Jo, S.K.9    Oh, K.H.10


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