Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration

Oncotarget

Volumn 6, Issue 22, 2015, Pages 18891-18904

  Zaytseva, Yekaterina Y ^a   Harris, Jennifer W ^a,b   Mitov, Mihail I ^a   Kim, Ji Tae ^a   Allan Butterfield, D ^a,c   Lee, Eun Y ^a,b   Weiss, Heidi L ^a   Gao, Tianyan ^a   Mark Evers, B ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Colorectal cancer; Energy homeostasis; FASN; Metabolic stress; Metastasis

Indexed keywords

FAT DROPLET; FATTY ACID; FATTY ACID SYNTHASE; LIPID; PROTEIN P62; FASN PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CARCINOGENESIS; CELL RESPIRATION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CLINICAL ARTICLE; COLON MUCOSA; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENERGY BALANCE; ENZYME ACTIVITY; ENZYME ANALYSIS; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPOGENESIS; LIVER METASTASIS; METABOLIC STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; COLORECTAL TUMOR; ENZYMOLOGY; GLYCOLYSIS; HCT 116 CELL LINE; HT-29 CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL RESPIRATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; FATTY ACID SYNTHASE, TYPE I; GLYCOLYSIS; HCT116 CELLS; HT29 CELLS; HUMANS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84938848149     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3783     Document Type: Article

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