A mutation in Caenorhabditis elegans NDUF-7 activates the mitochondrial stress response and prolongs lifespan via ROS and CED-4

G3: Genes, Genomes, Genetics

Volumn 5, Issue 8, 2015, Pages 1639-1648

  Rauthan, Manish ^a   Ranji, Parmida ^a   Abukar, Ragda ^a   Pilon, Marc ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Aging; Atfs 1; C. elegans; Ced 4; Mevalonate pathway; Mitochondria; Reactive oxygen species; Statin; UPRmt

Indexed keywords

ATFS 1 PROTEIN; CED 4 PROTEIN; CHAPERONIN 60; MEVALONIC ACID; NDUF 7 PROTEIN; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ATFS-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; CALCIUM BINDING PROTEIN; CED-4 PROTEIN, C ELEGANS; FLUINDOSTATIN; GLUTARALDEHYDE; INDOLE DERIVATIVE; MEVALDIC ACID; MONOUNSATURATED FATTY ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

ALLELE; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DELETION MUTANT; ENDOPLASMIC RETICULUM; GAIN OF FUNCTION MUTATION; LETHALITY; LIFE EXTENSION; LIFESPAN; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; RESPIRATORY CHAIN; SEQUENCE HOMOLOGY; STOP CODON; STRESS; UNFOLDED PROTEIN RESPONSE; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; LONGEVITY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGICAL STRESS; RNA INTERFERENCE;

ANIMALIA; CAENORHABDITIS ELEGANS;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM-BINDING PROTEINS; CHAPERONIN 60; ELECTRON TRANSPORT COMPLEX I; FATTY ACIDS, MONOUNSATURATED; GLUTARAL; INDOLES; LARVA; LONGEVITY; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84938833671     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.115.018598     Document Type: Article

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