Inhibition of group i metabotropic glutamate receptors reverses autistic-like phenotypes caused by deficiency of the translation repressor eiF4E binding protein 2

Journal of Neuroscience

Volumn 35, Issue 31, 2015, Pages 11125-11132

  Aguilar Valles, Argel ^a,b   Matta Camacho, Edna ^b   Khoutorsky, Arkady ^b   Gkogkas, Christos ^b,d   Nader, Karim ^c   Lacaille, Jean Claude ^a   Sonenberg, Nahum ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Autism spectrum disorders; Group I mGluRs; Long term depression; Repetitive behavior; Social interaction; Translation initiation

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; ANISOMYCIN; CYCLOHEXIMIDE; FENOBAM; INITIATION FACTOR 4E; JNJ16259685; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; (3,4-DIHYDRO-2H-PYRANO(2,3)B-QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL) METHANONE; AMINO ACID RECEPTOR BLOCKING AGENT; EIF4EBP2 PROTEIN, MOUSE; IMIDAZOLE DERIVATIVE; INITIATION FACTOR; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BRAIN ELECTROPHYSIOLOGY; COMPULSION; CONTROLLED STUDY; DOWN REGULATION; EUKARYOTIC INITIATION FACTOR 4E BINDING PROTEIN 2 GENE; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; LONG TERM DEPRESSION; MALE; MOUSE; NERVE STIMULATION; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SOCIAL INTERACTION; TASK PERFORMANCE; TRANSLATION INITIATION; TRANSLATION REGULATION; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PSYCHOLOGY; SOCIAL BEHAVIOR; STEREOTYPY;

ANIMALS; AUTISTIC DISORDER; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTORS; EXCITATORY AMINO ACID ANTAGONISTS; IMIDAZOLES; LONG-TERM SYNAPTIC DEPRESSION; MALE; MICE; MICE, KNOCKOUT; QUINOLINES; RECEPTORS, METABOTROPIC GLUTAMATE; SOCIAL BEHAVIOR; STEREOTYPED BEHAVIOR;

EID: 84938816866     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4615-14.2015     Document Type: Article

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