Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG-2 human hepatocellular carcinoma cells

Food and Function

Volumn 6, Issue 8, 2015, Pages 2588-2597

  Zhang, Tian Tian ^a   Yang, Li ^a   Jiang, Jian Guo ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; CHEMICAL ACTIVATION; DISEASES; DRUG PRODUCTS; MITOCHONDRIA; PHOSPHORYLATION; PLANTS (BOTANY); POLYMERASE CHAIN REACTION;

ANTICANCER ACTIVITIES; CELL-CYCLE ARREST; DNA FRAGMENTATION; HEPATOCELLULAR CARCINOMA CELL; INDUCED APOPTOSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MRNA EXPRESSION LEVEL; QUANTITATIVE REAL TIME PCR;

CELL DEATH;

CASPASE 3; CASPASE 9; CYCLIN D1; TANNIN; THONNINGIANIN A;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEPG2 CELL LINE; HUMAN; LIVER NEOPLASMS; METABOLISM; PATHOPHYSIOLOGY;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CYCLIN D1; HEP G2 CELLS; HUMANS; HYDROLYZABLE TANNINS; LIVER NEOPLASMS;

EID: 84938799858     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c5fo00388a     Document Type: Article

References (22)

1. M. A. Gyamfi Y. Aniya Antioxidant properties of Thonningianin A, isolated from the African medicinal herb Thonningia sanguine Biochem. Pharmacol. 2002 63 1725 1737
2. M. A. Gyamfi I. I. Ohtani E. Shinno Y. Aniya Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro Food Chem. Toxicol. 2004 42 1401 1408
3. Q. Lu M. H. Jiang J. G. Jiang R. F. Zhang M. W. Zhang Isolation and Identification of Compounds from Penthorum chinense Pursh with Antioxidant and Antihepatocarcinoma Properties J. Agric. Food Chem. 2012 60 11097 11103
4. E. Maeno T. Tsubata Y. Okada Apoptotic volume decrease (AVD) is independent of mitochondrial dysfunction and initiator caspase activation Cells 2012 1 1156 1167
5. A. Takahashi N. Ohtani K. Yamakoshi S. Iida H. Tahara K. Nakayama K. I. T. Nakayama Ide H. Saya E. Hara Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence Nat. Cell Biol. 2006 8 1291 1297
6. J. F. Passos T. VonZglinicki Oxygen free radicals in cell senescence: are they signal transducers? Free Radical Res. 2006 40 1277 1283
7. M. B. Azad Y. Chen S. B. Gibson Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment Antioxid. Redox Signaling 2009 11 777 790
8. M. L. Circu T. Y. Aw Reactive oxygen species, cellular redox systems, and apoptosis Free Radicals Biol. Med. 2010 48 749 762
9. A. Mathur Y. Hong B. Kemp A. A. Barrientos J. D. Erusalimsky Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes Cardiovasc. Res. 2000 46 126 138
10. S. Shimizu T. Takehara H. Hikita T. Kodama T. Miyagi A. Hosui T. Tatsumi H. Ishida T. Noda H. Nagano The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma J. Hepatol. 2010 52 698 704
11. R. J. Youle A. Strasser The BCL-2 protein family: opposing activities that mediate cell death Nat. Rev. Mol. Cell Biol. 2008 9 47 59
12. B. Relja F. Meder K. Wilhelm D. Henrich I. Marzi M. Lehnert Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells Int. J. Mol. Med. Adv. Sci. 2010 26 733 739
13. I. M. Ghobrial T. E. Witzig A. A. Adjei Targeting apoptosis pathways in cancer therapy Ca-Cancer J. Clin. 2005 55 178 194
14. S. B. Oh C. J. Hwang S. Y. Song Y. Y. Jung H. M. Yun C. H. Sok H. C. Sung J. M. Yi D. H. Park Y. W. Ham S. B. Han B. Y. Hwang J. T. Hong Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3 Cancer Lett. 2014 353 95 103
15. M. S. Hayden S. Ghosh NF-kappaB the first quarter-century: remarkable progress and outstanding questions Genes Dev. 2012 26 203 234
16. G. Madonna C. D. Ullman G. Gentilcore G. Palmieri P. A. Ascierto NF-kappaB as potential target in the treatment of melanoma J. Transl. Med. 2012 10 53
17. J. Y. Park J. Y. Song H. M. Kim H. S. Han H. S. Seol S. J. Jang J. Choi p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors Int. J. Biochem. Cell Biol. 2012 44 896 904
18. S. Boldt U. H. Weidleand W. Kolch The role of MAPK pathways in the action of chemotherapeutic drugs Carcinogenesis 2002 23 1831 1838
19. S. M. J. Fliedner T. Engel N. K. Lendvai U. Shankavaram S. Nolting R. Wesley A. G. Elkahloun H. Ungefroren A. Oldoerp G. Lampert Anti-cancer potential of MAPK pathway inhibition in Paragangliomas-effect of different statins on mouse pheochromocytoma cells PLoS One 2014 9 e97712
20. T. F. Chen W. J. Zheng Y. S. Wong F. Yang Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative Biomed. Pharmacother. 2008 62 77 84
21. S. Dwivedi Q. Saquib A. A. Al-Khedhairy J. Musarrat Butachlor induced dissipation of mitochondrial membrane potential, oxidative DNA damage and necrosis in human peripheral blood mononuclear cells Toxicology 2012 302 77 87
22. M. Tandon Z. J. Chen J. Pratap Runx2 activates PI3 K/Akt signaling via mTORC2 regulation in invasive breast cancer cells Breast Cancer Res. Treat. 2014 16 R16