IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ

PLoS Pathogens

Volumn 11, Issue 7, 2015, Pages

  Liu, Gongguan ^a   Xu, Jinjun ^a   Wu, Hui ^a   Sun, Donglei ^a   Zhang, Xiquan ^b   Zhu, Xiaoping ^a   Magez, Stefan ^c,d   Shi, Meiqing ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 27; MESSENGER RNA; IL27 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FLOW CYTOMETRY; GENETIC ANALYSIS; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATION; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN CELL; SURVIVAL; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL DEATH; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM;

MUS; PROTOZOA;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; INTERFERON-GAMMA; INTERLEUKINS; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; TRYPANOSOMA; TRYPANOSOMIASIS;

EID: 84938778043     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005065     Document Type: Article

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