메뉴 건너뛰기




Volumn 43, Issue , 2015, Pages 537-542

Targeting mitochondrial energy metabolism with TSPO ligands

Author keywords

Diabetes mellitus; Metabolic disease; Mitochondria; Mitochondrial drugs; PK 11195; Zebrafish

Indexed keywords

CARRIER PROTEIN; MITOCHONDRIAL PROTEIN; 4 AMINOBUTYRIC ACID RECEPTOR; LIGAND; TSPO PROTEIN, HUMAN;

EID: 84938775711     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20150019     Document Type: Article
Times cited : (23)

References (42)
  • 1
    • 84880673845 scopus 로고    scopus 로고
    • Pharmacological approaches to restore mitochondrial function
    • CrossRef PubMed
    • Andreux, P.A., Houtkooper, R.H. and Auwerx, J. (2013) Pharmacological approaches to restore mitochondrial function. Nat. Rev. Drug. Discov. 12, 465-483 CrossRef PubMed
    • (2013) Nat. Rev. Drug. Discov. , vol.12 , pp. 465-483
    • Andreux, P.A.1    Houtkooper, R.H.2    Auwerx, J.3
  • 3
    • 79959305691 scopus 로고    scopus 로고
    • Mitochondria: The next (neurode)generation
    • CrossRef PubMed
    • Schon, E.A. and Przedborski, S. (2011) Mitochondria: the next (neurode)generation. Neuron 70, 1033-1053 CrossRef PubMed
    • (2011) Neuron , vol.70 , pp. 1033-1053
    • Schon, E.A.1    Przedborski, S.2
  • 4
    • 84856415487 scopus 로고    scopus 로고
    • The role of mitochondria in insulin resistance and type 2 diabetes mellitus
    • CrossRef
    • Szendroedi, J., Phielix, E. and Roden, M. (2012) The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 8, 92-103 CrossRef
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 92-103
    • Szendroedi, J.1    Phielix, E.2    Roden, M.3
  • 5
    • 50049118173 scopus 로고    scopus 로고
    • Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype
    • CrossRef PubMed
    • Wenz, T., Diaz, F., Spiegelman, B.M. and Moraes, C.T. (2008) Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab. 8, 249-256 CrossRef PubMed
    • (2008) Cell Metab. , vol.8 , pp. 249-256
    • Wenz, T.1    Diaz, F.2    Spiegelman, B.M.3    Moraes, C.T.4
  • 8
    • 84896998596 scopus 로고    scopus 로고
    • Structure of the mitochondrial translocator protein in complex with a diagnostic ligand
    • CrossRef PubMed
    • Jaremko, L., Jaremko, M., Giller, K., Becker, S. and Zweckstetter, M. (2014) Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science 343, 1363-1366 CrossRef PubMed
    • (2014) Science , vol.343 , pp. 1363-1366
    • Jaremko, L.1    Jaremko, M.2    Giller, K.3    Becker, S.4    Zweckstetter, M.5
  • 10
    • 84877753769 scopus 로고    scopus 로고
    • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease
    • CrossRef PubMed
    • Barron, A.M., Garcia-Segura, L.M., Caruso, D., Jayaraman, A., Lee, J.W., Melcangi, R.C. and Pike, C.J. (2013) Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J. Neurosci. 33, 8891-8897 CrossRef PubMed
    • (2013) J. Neurosci. , vol.33 , pp. 8891-8897
    • Barron, A.M.1    Garcia-Segura, L.M.2    Caruso, D.3    Jayaraman, A.4    Lee, J.W.5    Melcangi, R.C.6    Pike, C.J.7
  • 13
    • 84860264736 scopus 로고    scopus 로고
    • The 18 kDa translocator protein (TSPO): A new perspective in mitochondrial biology
    • PubMed
    • Gatliff, J. and Campanella, M. (2012) The 18 kDa translocator protein (TSPO): a new perspective in mitochondrial biology. Curr. Mol. Med. 12, 356-368 PubMed
    • (2012) Curr. Mol. Med. , vol.12 , pp. 356-368
    • Gatliff, J.1    Campanella, M.2
  • 17
    • 84901008605 scopus 로고    scopus 로고
    • Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO))
    • CrossRef PubMed
    • Sileikyte, J., Blachly-Dyson, E., Sewell, R., Carpi, A., Menabo, R., Di Lisa, F., Ricchelli, F., Bernardi, P. and Forte, M. (2014) Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)). J. Biol. Chem. 289, 13769-13781 CrossRef PubMed
    • (2014) J. Biol. Chem. , vol.289 , pp. 13769-13781
    • Sileikyte, J.1    Blachly-Dyson, E.2    Sewell, R.3    Carpi, A.4    Menabo, R.5    Di Lisa, F.6    Ricchelli, F.7    Bernardi, P.8    Forte, M.9
  • 18
    • 84901463419 scopus 로고    scopus 로고
    • Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration
    • CrossRef PubMed
    • Lin, R., Angelin, A., Da Settimo, F., Martini, C., Taliani, S., Zhu, S. and Wallace, D.C. (2014) Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. Aging Cell 13, 507-518 CrossRef PubMed
    • (2014) Aging Cell , vol.13 , pp. 507-518
    • Lin, R.1    Angelin, A.2    Da Settimo, F.3    Martini, C.4    Taliani, S.5    Zhu, S.6    Wallace, D.C.7
  • 19
    • 0031755752 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern
    • PubMed
    • Li, H. and Papadopoulos, V. (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139, 4991-4997 PubMed
    • (1998) Endocrinology , vol.139 , pp. 4991-4997
    • Li, H.1    Papadopoulos, V.2
  • 20
    • 0028987664 scopus 로고
    • Involvement of peripheral-type benzodiazepine receptors in the intracellular transport of heme and porphyrins
    • PubMed
    • Taketani, S., Kohno, H., Furukawa, T. and Tokunaga, R. (1995) Involvement of peripheral-type benzodiazepine receptors in the intracellular transport of heme and porphyrins. J. Biochem. 117, 875-880 PubMed
    • (1995) J. Biochem. , vol.117 , pp. 875-880
    • Taketani, S.1    Kohno, H.2    Furukawa, T.3    Tokunaga, R.4
  • 21
    • 84886812954 scopus 로고    scopus 로고
    • The nexus of chromatin regulation and intermediary metabolism
    • CrossRef PubMed
    • Gut, P. and Verdin, E. (2013) The nexus of chromatin regulation and intermediary metabolism. Nature 502, 489-498 CrossRef PubMed
    • (2013) Nature , vol.502 , pp. 489-498
    • Gut, P.1    Verdin, E.2
  • 23
    • 0029978799 scopus 로고    scopus 로고
    • Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
    • PubMed
    • Winder, W.W. and Hardie, D.G. (1996) Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am. J. Physiol. 270, E299-E304 PubMed
    • (1996) Am. J. Physiol. , vol.270 , pp. E299-E304
    • Winder, W.W.1    Hardie, D.G.2
  • 25
    • 0027978729 scopus 로고
    • The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line
    • PubMed
    • Garnier, M., Boujrad, N., Ogwuegbu, S.O., Hudson, Jr, J.R. and Papadopoulos, V. (1994) The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line. J. Biol. Chem. 269, 22105-22112 PubMed
    • (1994) J. Biol. Chem. , vol.269 , pp. 22105-22112
    • Garnier, M.1    Boujrad, N.2    Ogwuegbu, S.O.3    Hudson, J.R.4    Papadopoulos, V.5
  • 26
    • 23944476164 scopus 로고    scopus 로고
    • Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha
    • CrossRef PubMed
    • Handschin, C., Lin, J., Rhee, J., Peyer, A.K., Chin, S., Wu, P.H., Meyer, U.A. and Spiegelman, B.M. (2005) Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell 122, 505-515 CrossRef PubMed
    • (2005) Cell , vol.122 , pp. 505-515
    • Handschin, C.1    Lin, J.2    Rhee, J.3    Peyer, A.K.4    Chin, S.5    Wu, P.H.6    Meyer, U.A.7    Spiegelman, B.M.8
  • 27
    • 0026051933 scopus 로고
    • Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors
    • CrossRef PubMed
    • Papadopoulos, V., Berkovich, A., Krueger, K.E., Costa, E. and Guidotti, A. (1991) Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology 129, 1481-1488 CrossRef PubMed
    • (1991) Endocrinology , vol.129 , pp. 1481-1488
    • Papadopoulos, V.1    Berkovich, A.2    Krueger, K.E.3    Costa, E.4    Guidotti, A.5
  • 32
    • 0037183733 scopus 로고    scopus 로고
    • Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice
    • CrossRef PubMed
    • Bribes, E., Bourrie, B., Esclangon, M., Galiegue, S., Vidal, H. and Casellas, P. (2002) Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice. Eur. J. Pharmacol. 452, 111-122 CrossRef PubMed
    • (2002) Eur. J. Pharmacol. , vol.452 , pp. 111-122
    • Bribes, E.1    Bourrie, B.2    Esclangon, M.3    Galiegue, S.4    Vidal, H.5    Casellas, P.6
  • 33
    • 84907293074 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis
    • CrossRef PubMed
    • Tu, L.N., Morohaku, K., Manna, P.R., Pelton, S.H., Butler, W.R., Stocco, D.M. and Selvaraj, V. (2014) Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis. J. Biol. Chem. 289, 27444-27454 CrossRef PubMed
    • (2014) J. Biol. Chem. , vol.289 , pp. 27444-27454
    • Tu, L.N.1    Morohaku, K.2    Manna, P.R.3    Pelton, S.H.4    Butler, W.R.5    Stocco, D.M.6    Selvaraj, V.7
  • 34
    • 84891469290 scopus 로고    scopus 로고
    • On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis
    • CrossRef PubMed
    • Papadopoulos, V. (2014) On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis. Endocrinology 155, 15-20 CrossRef PubMed
    • (2014) Endocrinology , vol.155 , pp. 15-20
    • Papadopoulos, V.1
  • 35
    • 77952548782 scopus 로고    scopus 로고
    • How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
    • CrossRef PubMed
    • Ristow, M. and Zarse, K. (2010) How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp. Gerontol. 45, 410-418 CrossRef PubMed
    • (2010) Exp. Gerontol. , vol.45 , pp. 410-418
    • Ristow, M.1    Zarse, K.2
  • 36
    • 84900295547 scopus 로고    scopus 로고
    • Mitohormesis
    • CrossRef PubMed
    • Yun, J. and Finkel, T. (2014) Mitohormesis. Cell Metab. 19, 757-766 CrossRef PubMed
    • (2014) Cell Metab. , vol.19 , pp. 757-766
    • Yun, J.1    Finkel, T.2
  • 39
    • 84860303350 scopus 로고    scopus 로고
    • PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells
    • PubMed
    • Seneviratne, M.S., Faccenda, D., De Biase, V. and Campanella, M. (2012) PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells. Curr. Mol. Med. 12, 476-482 PubMed
    • (2012) Curr. Mol. Med. , vol.12 , pp. 476-482
    • Seneviratne, M.S.1    Faccenda, D.2    De Biase, V.3    Campanella, M.4
  • 40
    • 33847035458 scopus 로고    scopus 로고
    • Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor
    • CrossRef PubMed
    • Cleary, J., Johnson, K.M., Opipari, Jr, A.W. and Glick, G.D. (2007) Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor. Bioorg Med. Chem. Lett. 17, 1667-1670 CrossRef PubMed
    • (2007) Bioorg Med. Chem. Lett. , vol.17 , pp. 1667-1670
    • Cleary, J.1    Johnson, K.M.2    Opipari, A.W.3    Glick, G.D.4
  • 41
    • 35348865444 scopus 로고    scopus 로고
    • Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols
    • CrossRef PubMed
    • Gledhill, J.R., Montgomery, M.G., Leslie, A.G. and Walker, J.E. (2007) Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. Proc. Natl. Acad. Sci. U.S.A. 104, 13632-13637 CrossRef PubMed
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 13632-13637
    • Gledhill, J.R.1    Montgomery, M.G.2    Leslie, A.G.3    Walker, J.E.4
  • 42
    • 84877309874 scopus 로고    scopus 로고
    • Rejuvenating SIRT1 activators
    • CrossRef PubMed
    • Gut, P. and Verdin, E. (2013) Rejuvenating SIRT1 activators. Cell Metab. 17, 635-637 CrossRef PubMed
    • (2013) Cell Metab. , vol.17 , pp. 635-637
    • Gut, P.1    Verdin, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.