Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration

Aging Cell

Volumn 13, Issue 3, 2014, Pages 507-518

  Lin, Ran ^a,b   Angelin, Alessia ^b   Da Settimo, Federico ^c   Martini, Claudia ^c   Taliani, Sabrina ^c   Zhu, Shigong ^a   Wallace, Douglas C ^b,d  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Drosophila; Longevity; Mitochondria; Neurodegeneration; TSPO

Indexed keywords

ACONITATE HYDRATASE; AMYLOID BETA PROTEIN[1-42]; CARRIER PROTEIN; CASPASE 3; CASPASE 7; HYDROGEN PEROXIDE; INSECT PROTEIN; OUTER MEMBRANE PROTEIN; TSPO PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-43); BZRP PROTEIN, MOUSE; DROSOPHILA PROTEIN; PEPTIDE FRAGMENT; TSPO PROTEIN, HUMAN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; EXPERIMENTAL NEUROPATHY; EXPOSURE; FEMALE; GAMMA IRRADIATION; GENE INSERTION; GENE SILENCING; GENETIC ANALYSIS; LIFESPAN; LIPID PEROXIDATION; LONGEVITY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; DEGENERATIVE DISEASE; DROSOPHILA; GENETICS; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE; MOLECULAR GENETICS; PATHOLOGY; PHYSIOLOGY;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; HUMANS; LONGEVITY; MALE; MITOCHONDRIAL MEMBRANES; MOLECULAR SEQUENCE DATA; NEURODEGENERATIVE DISEASES; PEPTIDE FRAGMENTS; RECEPTORS, GABA;

EID: 84901463419     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12200     Document Type: Article

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