ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells

Journal of Pharmacological Sciences

Volumn 128, Issue 3, 2015, Pages 97-107

  Zheng, Nan ^a   Zhang, Ping ^a   Huang, Huai ^a   Liu, Weiwei ^a   Hayashi, Toshihiko ^a   Zang, Linghe ^a   Zhang, Ye ^a   Liu, Lu ^a   Xia, Mingyu ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^c   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Institute for Clinical and Biomedical Sciences   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Autophagy; Estrogen receptor alpha (ER ); MPP dihydrochloride hydrate (MPP); Silibinin

Indexed keywords

CASPASE 6; ESTROGEN RECEPTOR ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SILIBININ; SMALL INTERFERING RNA; MTOR PROTEIN, HUMAN; SILYMARIN; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EXPOSURE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; BREAST TUMOR; DRUG EFFECTS; FEMALE; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; DOWN-REGULATION; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION; HUMANS; MAP KINASE SIGNALING SYSTEM; MCF-7 CELLS; SILYMARIN; TOR SERINE-THREONINE KINASES;

EID: 84938747023     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.05.001     Document Type: Article

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