Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 2, 2015, Pages 454-461.e9

  Stephenson, Susan T ^a   Brown, Lou Ann S ^a,b   Helms, My N ^a,b   Qu, Hongyan ^a   Brown, Sheena D ^a   Brown, Milton R ^a,b   Fitzpatrick, Anne M ^a,b  

^a EMORY UNIVERSITY   (United States)

^b CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

Author keywords

Biomarker; childhood asthma; cysteine; inflammation; oxidative stress; refractory asthma; severe asthma; treatment response

Indexed keywords

CXCL1 CHEMOKINE; CYSTEINE; FLUTICASONE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; TRIAMCINOLONE; CCL3 PROTEIN, HUMAN; CXCL1 PROTEIN, HUMAN; CYSTINE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ADOLESCENT; ARTICLE; ASTHMA; ASTHMA CONTROL QUESTIONNAIRE; BODY MASS; CELL VIABILITY; CHILD; CHILDHOOD DISEASE; CORTICOSTEROID THERAPY; CYSTEINE OXIDATION; DIFFICULT TO TREAT ASTHMA; DISEASE SEVERITY; DRUG MEGADOSE; FEMALE; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HUMAN; INFLAMMATION; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; OXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PEDIATRIC ASTHMA QUALITY OF LIFE QUESTIONNAIRE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; QUESTIONNAIRE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT RESPONSE; WESTERN BLOTTING; CHEMISTRY; DRUG EFFECTS; DRUG MONITORING; GENETICS; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; MONONUCLEAR CELL; OXIDATION REDUCTION REACTION; PATHOLOGY; PRIMARY CELL CULTURE;

ADMINISTRATION, INHALATION; ADOLESCENT; ASTHMA; CHEMOKINE CCL3; CHEMOKINE CXCL1; CHILD; CYSTEINE; CYSTINE; DRUG MONITORING; FEMALE; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; INJECTIONS, INTRAMUSCULAR; LEUKOCYTES, MONONUCLEAR; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PRIMARY CELL CULTURE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TRIAMCINOLONE;

EID: 84938741581     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.023     Document Type: Article

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