Children with severe asthma have unique oxidative stress-associated metabolomic profiles

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 1, 2014, Pages

  Fitzpatrick, Anne M ^a,b   Park, Youngja ^a,c   Brown, Lou Ann S ^a,b   Jones, Dean P ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^c Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYSTEINE; GLUTATHIONE; GLYCINE; METHACHOLINE; SALBUTAMOL; SERINE; THREONINE;

AMINO ACID METABOLISM; CORTICOSTEROID THERAPY; FORCED EXPIRATORY VOLUME; HUMAN; LETTER; METABOLOMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SEVERE PERSISTENT ASTHMA; SPIROMETRY; SYSTEMIC CIRCULATION;

ADOLESCENT; ADRENAL CORTEX HORMONES; ASTHMA; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; DRUG RESISTANCE; ETHANOLAMINES; FEMALE; GLYCINE; HUMANS; LIPID PEROXIDATION; MALE; METABOLOME; OXIDATIVE STRESS; SERINE; SPHINGOSINE N-ACYLTRANSFERASE; THREONINE;

EID: 84891682499     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.10.012     Document Type: Article

References (31)

1. P.J. Barnes Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease J Allergy Clin Immunol 131 2013 636 645
2. S.D. Brown, K.M. Baxter, S.T. Stephenson, A.M. Esper, L.A. Brown, and A.M. Fitzpatrick Airway TGF-beta1 and oxidant stress in children with severe asthma: association with airflow limitation J Allergy Clin Immunol 129 2012 388 396 396.e1-8
3. A.M. Fitzpatrick, D.P. Jones, and L.A. Brown Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities Antioxid Redox Signal 17 2012 375 408
4. A.M. Fitzpatrick, W.G. Teague, F. Holguin, M. Yeh, and L.A. Brown Severe Asthma Research Program. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress J Allergy Clin Immunol 123 2009 146 152.e8
5. A.M. Fitzpatrick, S.T. Stephenson, G.R. Hadley, L. Burwell, M. Penugonda, and D.M. Simon et al. Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2 J Allergy Clin Immunol 127 2011 1604 1611
6. A.M. Fitzpatrick, W.G. Teague, L. Burwell, M.S. Brown, and L.A. Brown NIH/NHLBI Severe Asthma Research Program. Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma Pediatr Res 69 2011 154 159
7. C.J. Bossley, S. Saglani, C. Kavanagh, D.N. Payne, N. Wilson, and L. Tsartsali et al. Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma Eur Respir J 34 2009 1052 1059
8. N. Ueda, K. Tsuboi, and T. Uyama Enzymological studies on the biosynthesis of N-acylethanolamines Biochim Biophys Acta 1801 2010 1274 1285
9. E.V. Berdyshev, P.C. Schmid, R.J. Krebsbach, C.J. Hillard, C. Huang, and N. Chen et al. Cannabinoid-receptor-independent cell signalling by N-acylethanolamines Biochem J 360 2001 67 75
10. R.S. Duncan, K.D. Chapman, and P. Koulen The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line Mol Neurodegener 4 2009 50
11. N.J. Serkova, T.J. Standiford, and K.A. Stringer The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses Am J Respir Crit Care Med 184 2011 647 655
12. A. Smolinska, L. Blanchet, L.M. Buydens, and S.S. Wijmenga NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review Anal Chim Acta 750 2012 82 97
13. T. Yu, Y. Park, S. Li, and D.P. Jones Hybrid feature detection and information accumulation using high-resolution LC-MS metabolomics data J Proteome Res 12 2013 1419 1427
14. D.P. Jones, Y. Park, and T.R. Ziegler Nutritional metabolomics: progress in addressing complexity in diet and health Annu Rev Nutr 32 2012 183 202
15. R. Kaddurah-Daouk, B.S. Kristal, and R.M. Weinshilboum Metabolomics: a global biochemical approach to drug response and disease Annu Rev Pharmacol Toxicol 48 2008 653 683
16. D.J. Adamko, B.D. Sykes, and B.H. Rowe The metabolomics of asthma: novel diagnostic potential Chest 141 2012 1295 1302
17. N.N. Jarjour, S.C. Erzurum, E.R. Bleecker, W.J. Calhoun, M. Castro, and S.A. Comhair et al. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program Am J Respir Crit Care Med 185 2012 356 362
18. E.F. Juniper, K. Gruffydd-Jones, S. Ward, and K. Svensson Asthma Control Questionnaire in children: validation, measurement properties, interpretation Eur Respir J 36 2010 1410 1416
19. E.F. Juniper, G.H. Guyatt, D.H. Feeny, P.J. Ferrie, L.E. Griffith, and M. Townsend Measuring quality of life in children with asthma Qual Life Res 5 1996 35 46
20. M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, and A. Coates et al. Standardisation of spirometry Eur Respir J 26 2005 319 338
21. J.L. Hankinson, J.R. Odencrantz, and K.B. Fedan Spirometric reference values from a sample of the general U.S. population Am J Respir Crit Care Med 159 1999 179 187
22. R.A. Dweik, P.B. Boggs, S.C. Erzurum, C.G. Irvin, M.W. Leigh, and J.O. Lundberg et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications Am J Respir Crit Care Med 184 2011 602 615
23. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society Am J Respir Crit Care Med 162 2000 2341 2351
24. National Asthma Education and Prevention Program Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma - Summary Report 2007 J Allergy Clin Immunol 120 2007 S94 138
25. J.R. Roede, Y. Park, S. Li, F.H. Strobel, and D.P. Jones Detailed mitochondrial phenotyping by high resolution metabolomics PLoS One 7 2012 e33020
26. T. Yu, Y. Park, J.M. Johnson, and D.P. Jones apLCMS-adaptive processing of high-resolution LC/MS data Bioinformatics 25 2009 1930 1936
27. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate - a practical and powerful approach to multiple testing J Royal Stat Soc Ser B 57 1995 289 300
28. J.D. Storey A direct approach to false discovery rates J Royal Stat Soc Ser B 64 2002 479 498
29. Y. Park, N.A. Le, T.W. Yu, F. Strobel, N. Gletsu-Miller, and C.J. Accardi et al. A sulfur amino acid-free meal increases plasma lipids in humans J Nutr 141 2011 1424 1431
30. M. Brown, W.B. Dunn, P. Dobson, Y. Patel, C.L. Winder, and S. Francis-McIntyre et al. Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics Analyst 134 2009 1322 1332
31. A.G. Marshall, C.L. Hendrickson, and G.S. Jackson Fourier transform ion cyclotron resonance mass spectrometry: a primer Mass Spectrom Rev 17 1998 1 35