-
1
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
T. Gerken, C.A. Girard, Y.C. Tung, C.J. Webby, V. Saudek, K.S. Hewitson, G.S. Yeo, M.A. McDonough, S. Cunliffe, L.A. McNeill, J. Galvanovskis, P. Rorsman, P. Robins, X. Prieur, A.P. Coll, M. Ma, Z. Jovanovic, I.S. Farooqi, B. Sedgwick, I. Barroso, T. Lindahl, C.P. Ponting, F.M. Ashcroft, S. O'Rahilly, and C.J. Schofield The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Science 318 2007 1469 1472
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
Girard, C.A.2
Tung, Y.C.3
Webby, C.J.4
Saudek, V.5
Hewitson, K.S.6
Yeo, G.S.7
McDonough, M.A.8
Cunliffe, S.9
McNeill, L.A.10
Galvanovskis, J.11
Rorsman, P.12
Robins, P.13
Prieur, X.14
Coll, A.P.15
Ma, M.16
Jovanovic, Z.17
Farooqi, I.S.18
Sedgwick, B.19
Barroso, I.20
Lindahl, T.21
Ponting, C.P.22
Ashcroft, F.M.23
O'Rahilly, S.24
Schofield, C.J.25
more..
-
2
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
T.M. Frayling, N.J. Timpson, M.N. Weedon, E. Zeggini, R.M. Freathy, C.M. Lindgren, J.R. Perry, K.S. Elliott, H. Lango, N.W. Rayner, B. Shields, L.W. Harries, J.C. Barrett, S. Ellard, C.J. Groves, B. Knight, A.M. Patch, A.R. Ness, S. Ebrahim, D.A. Lawlor, S.M. Ring, Y. Ben-Shlomo, M.R. Jarvelin, U. Sovio, A.J. Bennett, D. Melzer, L. Ferrucci, R.J. Loos, I. Barroso, N.J. Wareham, F. Karpe, K.R. Owen, L.R. Cardon, M. Walker, G.A. Hitman, C.N. Palmer, A.S. Doney, A.D. Morris, G.D. Smith, A.T. Hattersley, and M.I. McCarthy A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 2007 889 894
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
Lindgren, C.M.6
Perry, J.R.7
Elliott, K.S.8
Lango, H.9
Rayner, N.W.10
Shields, B.11
Harries, L.W.12
Barrett, J.C.13
Ellard, S.14
Groves, C.J.15
Knight, B.16
Patch, A.M.17
Ness, A.R.18
Ebrahim, S.19
Lawlor, D.A.20
Ring, S.M.21
Ben-Shlomo, Y.22
Jarvelin, M.R.23
Sovio, U.24
Bennett, A.J.25
Melzer, D.26
Ferrucci, L.27
Loos, R.J.28
Barroso, I.29
Wareham, N.J.30
Karpe, F.31
Owen, K.R.32
Cardon, L.R.33
Walker, M.34
Hitman, G.A.35
Palmer, C.N.36
Doney, A.S.37
Morris, A.D.38
Smith, G.D.39
Hattersley, A.T.40
McCarthy, M.I.41
more..
-
3
-
-
85047688293
-
The bigger picture of FTO-the first GWAS-identified obesity gene
-
R.J.F. Loos, and G.S.H. Yeo The bigger picture of FTO-the first GWAS-identified obesity gene Nat. Rev. Endocrinol. 10 2014 51 61
-
(2014)
Nat. Rev. Endocrinol.
, vol.10
, pp. 51-61
-
-
Loos, R.J.F.1
Yeo, G.S.H.2
-
4
-
-
84873492810
-
Emerging function of fat mass and obesity-associated protein (fto)
-
T.D. Müller, M.H. Tschöp, and S. Hofmann Emerging function of fat mass and obesity-associated protein (fto) PLoS Genet. 9 2013 e1003223
-
(2013)
PLoS Genet.
, vol.9
-
-
Müller, T.D.1
Tschöp, M.H.2
Hofmann, S.3
-
5
-
-
84897855294
-
Obesity-associated variants within FTO form long-range functional connections with IRX3
-
S. Smemo, J.J. Tena, K.-H. Kim, E.R. Gamazon, N.J. Sakabe, C. Gómez-Marín, I. Aneas, F.L. Credidio, D.R. Sobreira, N.F. Wasserman, J.H. Lee, V. Puviindran, D. Tam, M. Shen, J.E. Son, N.A. Vakili, H.-K. Sung, S. Naranjo, R.D. Acemel, M. Manzanares, A. Nagy, N.J. Cox, C.-C. Hui, J.L. Gomez-Skarmeta, and M.A. Nobrega Obesity-associated variants within FTO form long-range functional connections with IRX3 Nature 2014 1 17
-
(2014)
Nature
, pp. 1-17
-
-
Smemo, S.1
Tena, J.J.2
Kim, K.-H.3
Gamazon, E.R.4
Sakabe, N.J.5
Gómez-Marín, C.6
Aneas, I.7
Credidio, F.L.8
Sobreira, D.R.9
Wasserman, N.F.10
Lee, J.H.11
Puviindran, V.12
Tam, D.13
Shen, M.14
Son, J.E.15
Vakili, N.A.16
Sung, H.-K.17
Naranjo, S.18
Acemel, R.D.19
Manzanares, M.20
Nagy, A.21
Cox, N.J.22
Hui, C.-C.23
Gomez-Skarmeta, J.L.24
Nobrega, M.A.25
more..
-
6
-
-
84899900892
-
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice
-
G. Stratigopoulos, J.F. Martin Carli, D.R. O'Day, L. Wang, C.A. Leduc, P. Lanzano, W.K. Chung, M. Rosenbaum, D. Egli, D.A. Doherty, and R.L. Leibel Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice Cell Metab. 19 2014 767 779
-
(2014)
Cell Metab.
, vol.19
, pp. 767-779
-
-
Stratigopoulos, G.1
Martin Carli, J.F.2
O'Day, D.R.3
Wang, L.4
Leduc, C.A.5
Lanzano, P.6
Chung, W.K.7
Rosenbaum, M.8
Egli, D.9
Doherty, D.A.10
Leibel, R.L.11
-
7
-
-
78649459183
-
Overexpression of Fto leads to increased food intake and results in obesity
-
C. Church, L. Moir, F. McMurray, C. Girard, G.T. Banks, L. Teboul, S. Wells, J.C. Bruning, P.M. Nolan, F.M. Ashcroft, and R.D. Cox Overexpression of Fto leads to increased food intake and results in obesity Nat. Genet. 42 2010 1086 1092
-
(2010)
Nat. Genet.
, vol.42
, pp. 1086-1092
-
-
Church, C.1
Moir, L.2
McMurray, F.3
Girard, C.4
Banks, G.T.5
Teboul, L.6
Wells, S.7
Bruning, J.C.8
Nolan, P.M.9
Ashcroft, F.M.10
Cox, R.D.11
-
8
-
-
67649875640
-
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
-
S. Boissel, O. Reish, K. Proulx, H. Kawagoe-Takaki, B. Sedgwick, G.S. Yeo, D. Meyre, C. Golzio, F. Molinari, N. Kadhom, H.C. Etchevers, V. Saudek, I.S. Farooqi, P. Froguel, T. Lindahl, S. O'Rahilly, A. Munnich, and L. Colleaux Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations Am. J. Hum. Genet. 85 2009 106 111
-
(2009)
Am. J. Hum. Genet.
, vol.85
, pp. 106-111
-
-
Boissel, S.1
Reish, O.2
Proulx, K.3
Kawagoe-Takaki, H.4
Sedgwick, B.5
Yeo, G.S.6
Meyre, D.7
Golzio, C.8
Molinari, F.9
Kadhom, N.10
Etchevers, H.C.11
Saudek, V.12
Farooqi, I.S.13
Froguel, P.14
Lindahl, T.15
O'Rahilly, S.16
Munnich, A.17
Colleaux, L.18
-
9
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
J. Fischer, L. Koch, C. Emmerling, J. Vierkotten, T. Peters, J.C. Bruning, and U. Ruther Inactivation of the Fto gene protects from obesity Nature 458 2009 894 898
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
Koch, L.2
Emmerling, C.3
Vierkotten, J.4
Peters, T.5
Bruning, J.C.6
Ruther, U.7
-
10
-
-
79955755011
-
Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression
-
P.K. Olszewski, R. Fredriksson, J.D. Eriksson, A. Mitra, K.J. Radomska, B.A. Gosnell, M.N. Solvang, A.S. Levine, and H.B. Schioth Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression Biochem. Biophys. Res. Commun. 408 2011 422 426
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.408
, pp. 422-426
-
-
Olszewski, P.K.1
Fredriksson, R.2
Eriksson, J.D.3
Mitra, A.4
Radomska, K.J.5
Gosnell, B.A.6
Solvang, M.N.7
Levine, A.S.8
Schioth, H.B.9
-
11
-
-
84873735640
-
Role for the obesity-related FTO gene in the cellular sensing of amino acids
-
P. Gulati, M.K. Cheung, R. Antrobus, C.D. Church, H.P. Harding, Y.C. Tung, D. Rimmington, M. Ma, D. Ron, P.J. Lehner, F.M. Ashcroft, R.D. Cox, A.P. Coll, S. O'Rahilly, and G.S. Yeo Role for the obesity-related FTO gene in the cellular sensing of amino acids Proc. Natl. Acad. Sci. U. S. A. 110 2013 2557 2562
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 2557-2562
-
-
Gulati, P.1
Cheung, M.K.2
Antrobus, R.3
Church, C.D.4
Harding, H.P.5
Tung, Y.C.6
Rimmington, D.7
Ma, M.8
Ron, D.9
Lehner, P.J.10
Ashcroft, F.M.11
Cox, R.D.12
Coll, A.P.13
O'Rahilly, S.14
Yeo, G.S.15
-
12
-
-
84881257670
-
A link between FTO, ghrelin, and impaired brain food-cue responsivity
-
E. Karra, O.G. O'Daly, A.I. Choudhury, A. Yousseif, S. Millership, M.T. Neary, W.R. Scott, K. Chandarana, S. Manning, M.E. Hess, H. Iwakura, T. Akamizu, Q. Millet, C. Gelegen, M.E. Drew, S. Rahman, J.J. Emmanuel, S.C.R. Williams, U.U. Rüther, J.C. Brüning, D.J. Withers, F.O. Zelaya, and R.L. Batterham A link between FTO, ghrelin, and impaired brain food-cue responsivity J. Clin. Invest. 123 2013 3539 3551
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3539-3551
-
-
Karra, E.1
O'Daly, O.G.2
Choudhury, A.I.3
Yousseif, A.4
Millership, S.5
Neary, M.T.6
Scott, W.R.7
Chandarana, K.8
Manning, S.9
Hess, M.E.10
Iwakura, H.11
Akamizu, T.12
Millet, Q.13
Gelegen, C.14
Drew, M.E.15
Rahman, S.16
Emmanuel, J.J.17
Williams, S.C.R.18
Rüther, U.U.19
Brüning, J.C.20
Withers, D.J.21
Zelaya, F.O.22
Batterham, R.L.23
more..
-
13
-
-
81355146483
-
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
-
G. Jia, Y. Fu, X. Zhao, Q. Dai, G. Zheng, Y. Yang, C. Yi, T. Lindahl, T. Pan, Y.G. Yang, and C. He N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO Nat. Chem. Biol. 7 2011 885 887
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 885-887
-
-
Jia, G.1
Fu, Y.2
Zhao, X.3
Dai, Q.4
Zheng, G.5
Yang, Y.6
Yi, C.7
Lindahl, T.8
Pan, T.9
Yang, Y.G.10
He, C.11
-
16
-
-
78649687209
-
Circadian integration of metabolism and energetics
-
J. Bass, and J.S. Takahashi Circadian integration of metabolism and energetics Science 330 2010 1349 1354
-
(2010)
Science
, vol.330
, pp. 1349-1354
-
-
Bass, J.1
Takahashi, J.S.2
-
17
-
-
77957266573
-
JTK-CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets
-
M.E. Hughes, J.B. Hogenesch, and K. Kornacker JTK-CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets J. Biol. Rhyth. 25 2010 372 380
-
(2010)
J. Biol. Rhyth.
, vol.25
, pp. 372-380
-
-
Hughes, M.E.1
Hogenesch, J.B.2
Kornacker, K.3
-
18
-
-
47749140333
-
SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
-
G. Asher, D. Gatfield, M. Stratmann, H. Reinke, C. Dibner, F. Kreppel, R. Mostoslavsky, F.W. Alt, and U. Schibler SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation Cell 134 2008 317 328
-
(2008)
Cell
, vol.134
, pp. 317-328
-
-
Asher, G.1
Gatfield, D.2
Stratmann, M.3
Reinke, H.4
Dibner, C.5
Kreppel, F.6
Mostoslavsky, R.7
Alt, F.W.8
Schibler, U.9
-
19
-
-
33746344698
-
The polycomb group protein EZH2 is required for mammalian circadian clock function
-
J.P. Etchegaray, X. Yang, J.P. DeBruyne, A.H. Peters, D.R. Weaver, T. Jenuwein, and S.M. Reppert The polycomb group protein EZH2 is required for mammalian circadian clock function J. Biol. Chem. 281 2006 21209 21215
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 21209-21215
-
-
Etchegaray, J.P.1
Yang, X.2
DeBruyne, J.P.3
Peters, A.H.4
Weaver, D.R.5
Jenuwein, T.6
Reppert, S.M.7
-
20
-
-
20444502998
-
The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1
-
M. Akashi, and T. Takumi The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1, Nat. Struct. Mol. Biol. 12 2005 441 448
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 441-448
-
-
Akashi, M.1
Takumi, T.2
-
21
-
-
11144353910
-
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
-
S.H. Yoo, S. Yamazaki, P.L. Lowrey, K. Shimomura, C.H. Ko, E.D. Buhr, S.M. Siepka, H.K. Hong, W.J. Oh, O.J. Yoo, M. Menaker, and J.S. Takahashi PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues Proc. Natl. Acad. Sci. U. S. A. 101 2004 5339 5346
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 5339-5346
-
-
Yoo, S.H.1
Yamazaki, S.2
Lowrey, P.L.3
Shimomura, K.4
Ko, C.H.5
Buhr, E.D.6
Siepka, S.M.7
Hong, H.K.8
Oh, W.J.9
Yoo, O.J.10
Menaker, M.11
Takahashi, J.S.12
-
23
-
-
84887875528
-
RNA-methylation-dependent RNA processing controls the speed of the circadian clock
-
J.-M. Fustin, M. Doi, Y. Yamaguchi, H. Hida, S. Nishimura, M. Yoshida, T. Isagawa, M.S. Morioka, H. Kakeya, I. Manabe, and H. Okamura RNA-methylation-dependent RNA processing controls the speed of the circadian clock Cell 155 2013 793 806
-
(2013)
Cell
, vol.155
, pp. 793-806
-
-
Fustin, J.-M.1
Doi, M.2
Yamaguchi, Y.3
Hida, H.4
Nishimura, S.5
Yoshida, M.6
Isagawa, T.7
Morioka, M.S.8
Kakeya, H.9
Manabe, I.10
Okamura, H.11
-
24
-
-
84949115887
-
Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm
-
P. Gulati, E. Avezov, M. Ma, R. Antrobus, P. Lehner, S. O'Rahilly, and G.S. Yeo Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm Biosci. Rep. 34 2014
-
(2014)
Biosci. Rep.
, vol.34
-
-
Gulati, P.1
Avezov, E.2
Ma, M.3
Antrobus, R.4
Lehner, P.5
O'Rahilly, S.6
Yeo, G.S.7
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