Methotrexate influx via folate transporters into alveolar epithelial cell line A549

Drug Metabolism and Pharmacokinetics

Volumn 30, Issue 4, 2015, Pages 276-281

  Kawami, Masashi ^a   Miyamoto, Mioka ^a   Yumoto, Ryoko ^a   Takano, Mikihisa ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Alveolar epithelial cells; Folic acid; Methotrexate; Proton coupled folate transporter; Reduced folate carrier

Indexed keywords

FOLIC ACID; MESSENGER RNA; METHOTREXATE; PROTON COUPLED FOLATE TRANSPORTER; REDUCED FOLATE CARRIER; SALAZOSULFAPYRIDINE; THIAMINE PHOSPHATE; CARRIER PROTEIN; FOLATE TRANSPORTER; SLC46A1 PROTEIN, HUMAN;

A549 CELL LINE; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC50; LUNG ALVEOLUS EPITHELIUM CELL; PH; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROSETTE FORMING CELL; TEMPERATURE DEPENDENCE; DRUG EFFECTS; EPITHELIUM CELL; KINETICS; LUNG ALVEOLUS; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE, TUMOR; EPITHELIAL CELLS; FOLIC ACID; FOLIC ACID TRANSPORTERS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; METHOTREXATE; PROTON-COUPLED FOLATE TRANSPORTER; PULMONARY ALVEOLI; SULFASALAZINE;

EID: 84938740630     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.1016/j.dmpk.2015.04.005     Document Type: Article

References (39)

1. C.H. Pui, and W.E. Evans Treatment of acute lymphoblastic leukemia N Engl J Med 354 2006 166 178
2. D.E. Furst The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases Br J Rheumatol 36 1997 1196 1204
3. H.H. Roenigk Jr., R. Auerbach, H. Maibach, G. Weinstein, and M. Lebwohl Methotrexate in psoriasis: consensus conference J Am Acad Dermatol 38 1998 478 485
4. B.N. Cronstein Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis Pharmacol Rev 57 2005 163 172
5. A.F. Wells, R. Westhovens, D.M. Reed, L. Fanti, J.C. Becker, A. Covucci, and et al. Abatacept plus methotrexate provides incremental clinical benefits versus methotrexate alone in methotrexate-naive patients with early rheumatoid arthritis who achieve radiographic nonprogression J Rheumatol 38 2011 2362 2368
6. J. Rueda Gotor, and R. Blanco Alonso Tocilizumab in rheumatoid arthritis Reumatol Clin 2011 6S3 S29-32
7. K. Inoue, and H. Yuasa Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy Drug Metab Pharmacokinet 29 2014 12 19
8. Acute lymphocytic leukemia in children maintenance therapy with methotrexat administered intermittently. Acute Leukemia group B JAMA 207 1969 923 928
9. P. Barrera, R.F. Laan, P.L. van Riel, P.N. Dekhuijzen, A.M. Boerbooms, and L.B. van de Putte Methotrexate-related pulmonary complications in rheumatoid arthritis Ann Rheum Dis 53 1994 434 439
10. S. Imokawa, T.V. Colby, K.O. Leslie, and R.A. Helmers Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients Eur Respir J 15 2000 373 381
11. C. Roubille, and B. Haraoui Interstitial lung diseases induced or exacerbated by DMARDS and biologic agents in rheumatoid arthritis: a systematic literature review Semin Arthritis Rheum 43 2014 613 626
12. M. Ohbayashi, C. Yamamoto, A. Shiozawa, N. Kohyama, Y. Kobayashi, and T. Yamamoto Differential mRNA expression and the uptake of methotrexate in primary MAEC and MLF cells: involvement of the Abc and Slco/Oatp transporters in alveolar epithelial cell toxicity J Toxicol Sci 38 2013 103 114
13. I.D. Goldman, N.S. Lichtenstein, and V.T. Oliverio Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell J Biol Chem 243 1968 5007 5017
14. I.D. Goldman, and L.H. Matherly The cellular pharmacology of methotrexate Pharmacol Ther 28 1985 77 102
15. F.M. Sirotnak, and B. Tolner Carrier-mediated membrane transport of folates in mammalian cells Annu Rev Nutr 19 1999 91 122
16. M. Shayeghi, G.O. Latunde-Dada, J.S. Oakhill, A.H. Laftah, K. Takeuchi, N. Halliday, and et al. Identification of an intestinal heme transporter Cell 122 2005 789 801
17. A. Qiu, M. Jansen, A. Sakaris, S.H. Min, S. Chattopadhyay, E. Tsai, and et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption Cell 127 2006 917 928
18. Y. Nakai, K. Inoue, N. Abe, M. Hatakeyama, K.Y. Ohta, M. Otagiri, and et al. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter J Pharmacol Exp Ther 322 2007 469 476
19. H. Yuasa, K. Inoue, and Y. Hayashi Molecular and functional characteristics of proton-coupled folate transporter J Pharm Sci 98 2009 1608 1616
20. C.H. Yun, C.M. Tse, S. Nath, S.L. Levine, and M. Donowitz Structure/function studies of mammalian Na-H exchangers-an update J Physiol 482 1995 1S 6S
21. R. Zhao, L.H. Matherly, and I.D. Goldman Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues Expert Rev Mol Med 11 2009 e4
22. D.W. Horne Na+ and pH dependence of 5-methyltetrahydrofolic acid and methotrexate transport in freshly isolated hepatocytes Biochim Biophys Acta 1023 1990 47 55
23. N.A. Wani, and J. Kaur Adaptive transport of folic acid across renal epithelia in folate-deficient rats J Physiol Sci 62 2012 461 468
24. J.R. Araujo, P. Goncalves, and F. Martel Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells Biofactors 36 2010 201 209
25. S. Endter, D. Francombe, C. Ehrhardt, and M. Gumbleton RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models J Pharm Pharmacol 61 2009 583 591
26. M. Takano, E. Kimura, S. Suzuki, J. Nagai, and R. Yumoto Human erythrocyte nucleoside transporter ENT1 functions at ice-cold temperatures Drug Metab Pharmacokinet 25 2010 351 360
27. Y. Wang, R. Zhao, and I.D. Goldman Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier Clin Cancer Res 10 2004 6256 6264
28. E.E. Sierra, K.E. Brigle, M.J. Spinella, and I.D. Goldman pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH Biochem Pharmacol 53 1997 223 231
29. R. Zhao, A. Qiu, E. Tsai, M. Jansen, M.H. Akabas, and I.D. Goldman The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier Mol Pharmacol 74 2008 854 862
30. J.R. Whetstine, R.M. Flatley, and L.H. Matherly The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter Biochem J 367 2002 629 640
31. R. Zhao, F. Gao, and I.D. Goldman Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells Am J Physiol Cell Physiol 282 2002 C1512 C1517
32. B.L. Urquhart, J.C. Gregor, N. Chande, M.J. Knauer, R.G. Tirona, and R.B. Kim The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs Am J Physiol Gastrointest Liver Physiol 298 2010 G248 G254
33. G. Jansen, J. van der Heijden, R. Oerlemans, W.F. Lems, I. Ifergan, R.J. Scheper, and et al. Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis Arthritis Rheum 50 2004 2130 2139
34. A. Tomaru, N. Morimoto, M. Morishita, K. Takayama, T. Fujita, K. Maeda, and et al. Studies on the intestinal absorption characteristics of sulfasalazine, a breast cancer resistance protein (BCRP) substrate Drug Metab Pharmacokinet 28 2013 71 74
35. E. van de Steeg, A. van Esch, E. Wagenaar, K.E. Kenworthy, and A.H. Schinkel Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice Clin Cancer Res 19 2013 821 832
36. I. Badagnani, R.A. Castro, T.R. Taylor, C.M. Brett, C.C. Huang, D. Stryke, and et al. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants J Pharmacol Exp Ther 318 2006 521 529
37. M. Takeda, S. Khamdang, S. Narikawa, H. Kimura, M. Hosoyamada, S.H. Cha, and et al. Characterization of methotrexate transport and its drug interactions with human organic anion transporters J Pharmacol Exp Ther 302 2002 666 671
38. M.J. Spinella, K.E. Brigle, E.E. Sierra, and I.D. Goldman Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells J Biol Chem 270 1995 7842 7849
39. E.E. Sierra, K.E. Brigle, M.J. Spinella, and I.D. Goldman Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells Biochem Pharmacol 50 1995 1287 1294