Reduced folate carrier transports thiamine monophosphate: An alternative route for thiamine delivery into mammalian cells

American Journal of Physiology - Cell Physiology

Volumn 282, Issue 6 51-6, 2002, Pages

  Zhao, Rongbao ^a   Gao, Feng ^a   David Goldman, I ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

SLC19A transporters; Thiamine homeostasis; Thiamine pyrophosphate; Thiamine responsive megaloblastic anemia; Vitamin B1 uptake

Indexed keywords

COCARBOXYLASE; FOLIC ACID; METHOTREXATE; REDUCED FOLATE CARRIER; THIAMINE; THIAMINE PHOSPHATE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL TRANSPORT; CONTROLLED STUDY; HYDROLYSIS; LEUKEMIA CELL; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0036085901     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00547.2001     Document Type: Article

References (39)

1. Mechanism of thiamine transport in neuroblastoma cells. Inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP
2. Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line
3. Transport of thiamine by brush-border membrane vesicles from rat small intestine
4. RFC-1 gene expression regulates folate absorption in mouse small intestine
5. Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome
6. Cloning of the human thiamine transporter, a member of the folate transporter family
7. Identification and characterization of the human and mouse SLC19A3 gene: A novel member of the reduced folate family of micronutrient transporter genes
8. Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3
9. The gene mutated in thiamineresponsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter
10. Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascited tumor cell in vitro
11. Intestinal transport of thiamin and thiamin monophosphate in rat everted jejunal sacs: A comparative study using some potential inhibitors
12. The characteristics of the membrane transport of amethopterin and the naturally occurring folates
13. Thiamine transport in human placental brush border membrane vesicles
14. A novel mutation in the SLC19A2 gene in a Tunisian family with thiamine-responsive megaloblastic anaemia, diabetes and deafness syndrome
15. Binding properties of the 5-methyltetrahydrofolate/methotrexate transport system in L1210 cells
16. Structural requirements for anion substrates of the methotrexate transport system of L1210 cells
17. Neuropathology of thiamine deficiency disorders
18. Comparison of intestinal folate carrier clone expressed in IEC-6 cells and in Xenopus oocytes
19. Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness
20. Thin-layer chromatography and determination of thiamine salts, phosphoric esters, disulphides, and their respective thiochromes
21. Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum
22. Molecular and cellular biology of the human reduced folate carrier
23. SLC19A3 encodes a second thiamine transporter, ThTr2
24. Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities
25. The spectrum of mutations, including four novel ones, in the thiamine-responsive megaloblastic anemia gene SLC19A2 of eight families
26. Thiamine intestinal transport and related issues: Recent aspects
27. Effect of ethanol on the in vivo kinetics of thiamine phosphorylation and dephosphorylation in different organs of rat-II. Acute effects
28. Thiamine-responsive megaloblastic anemia
29. The major facilitator superfamily
30. A novel mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I
31. Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line
32. Thiamine transport in the central nervous system
33. Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts
34. Determination of thiamin and its phosphate esters in human blood, plasma, and urine
35. Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis
36. Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: Directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier
37. Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells
38. Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs
39. Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells