Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells

BioFactors

Volumn 36, Issue 3, 2010, Pages 201-209

  Araújo, João R ^a   Gonçalves, Pedro ^a   Martel, Fátima ^a  

^a University of Porto   (Portugal)

Author keywords

Blood brain barrier; Folate; Methyltetrahydrofolate; Uptake

Indexed keywords

4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 METHYLTETRAHYDROFOLIC ACID; CARBON 14; CHLORIDE ION; CYTOCHALASIN D; FLUORINE; FOLIC ACID; MESSENGER RNA; METHOTREXATE; MONENSIN; REDUCED FOLATE CARRIER; SODIUM ION; TRITIUM;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ENDOTHELIUM CELL; ENERGY; HUMAN; HUMAN CELL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CARBON RADIOISOTOPES; CELL LINE; ENDOTHELIAL CELLS; FOLIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS;

EID: 77955752884     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.82     Document Type: Article

References (29)

1. Roux, F. and Couraud, P. O. (2005) Rat brain endothelial cell lines for the study of blood.brain barrier permeability and transport functions. Cell Mol. Neurobiol. 25, 41-58.
2. Weksler, B. B., Subileau, E. A., Perrière, N., Charneau, P., Holloway, K., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., Male, D. K., Roux, F., Greenwood, J., Romero, I. A., and Couraud, P. O. (2005) Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J. 19, 1872-1874.
3. Herbert, V. (1999) Folic acid. In Modern Nutrition in Health and Disease, ed. 9. (Shils, M. E., Olson, J. A., Shike, M., Ross, A. H., eds.). pp. 433-446, Lippincott Williams & Wilkins, London.
4. Lucock, M. (2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol. Gen. Metab. 71, 121-138.
5. Worthington-Roberts, B. S. (1999) Nutrition. In Cherry and Merkatz's Complications of Pregnancy, ed. 5. (Cohen, W. R., Cherry, S. H., Merkatz, I. R., eds.). pp. 17-49, Lippincott Williams & Wilkins, London.
6. Zhao, R., Matherly, L. H., and Goldman, I. D. (2009) Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Exp. Rev. Mol. Med. 11, e4.
7. Serot, J. M., Christmann, D., Dubost, T., Bene, M. C., and Faure, G. C. (2001) CSF-folate levels are decreased in late-onset AD patients. J. Neural. Transm. 108, 93-99.
8. Snowdon, D. A., Tully, C. L., Smith, C. D., Riley, K. P., and Markesbery, W. R. (2000) Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study. Am. J. Clin. Nutr. 71, 993-998.
9. Duan, W., Ladenheim, B., Cutler, R. G., Kruman, I. I., Cadet, J. L., and Mattson, M. P. (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J. Neurochem. 80, 101-110.
10. Endres, M., Ahmadi, M., Kruman, I., Biniszkiewicz, D., Meisel, A., and Gertz, K. (2005) Folate deficiency increases postischemic brain injury. Stroke 36, 321-325.
11. Giles, W. H., Kittner, S. J., Anda, R. F., Croft, J. B., and Casper, M. L. (1995) Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study. Stroke 26, 1166-1170.
12. Aisen, P. S., Schneider, L. S., Sano, M., Diaz-Arrastia, R., van Dyck, C. H., Weiner, M. F., Bottiglieri, T., Jin, S., Stokes, K. T., Thomas, R. G., Thal, L. J., Alzheimer Disease Cooperative Study. (2008) High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 300, 1774-1783.
13. Maron, B. A. and Loscalzo, J. (2009) The treatment of hyperhomocysteinemia. Annu. Rev. Med. 60, 39-54.
14. Qiu, A., Jansen, M., Sakaris, A., Min, S., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M., and Goldman, I. D. (2006) Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127, 917-928.
15. Zhao, R., Min, S. H., Qiu, A., Sakaris, A., Goldberg, G. L., Sandoval, C., Malatack, J. J., Rosenblatt, D. S., Goldman, I. D. (2007) The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood 110, 1147-1152.
16. Ramaekers, V. T. and Blau, N. (2004) Cerebral folate deficiency. Dev. Med. Child Neurol. 46, 843-851.
17. Ramaekers, V. T., Rothenberg, S. P., Sequeira, A. J., Opladen, T., Blau, N., Quadros, E. V., and Slhub, J. (2005) Autoantibodies to folate receptors in the cerebral. N. Engl. J. Med. 52, 1985-1991.
18. Steinfeld, R., Grapp, M., Kraetzner, R., Dreha-Kulaczewski, S., Helms, G., Dechent, P., Wevers, R., Grosso, S., and Gärtner, J. Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism. Am. J. Hum. Genet. 85, 354-363.
19. Wu, D. and Pardridge, W. M. (1999) Blood-brain barrier transport of reduced folic acid. Pharm. Res. 16, 415-419.
20. Bradford, M. M. (1976) A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
21. Muzyka, A., Tarkany, O., Yelizanof, V., Sergienko, U., and Boichuk, A. (2005) Non-Linear Regression (Curve Fit), GraphPad Prism for Windows, San Diego, CA.
22. Roux, F., Durieu-Trautmann, O., Chaverot, N., Claire, M., Mailly, P., Bourre, J. M., Strosberg, A. D., and Couraud, P. O. (1994) Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell Physiol. 159, 101-113.
23. Afonso, P. V., Ozden, S., Prevost, M. C., Schmitt, C., Seilhean, D., Weksler, B., Couraud, P. O., Gessain, A., Romero, I. A., and Ceccaldi, P. E. (2007) Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization. J. Immunol. 179, 2576-2583.
24. Andras, I. E., Rha, G., Huang, W., Eum, S., Couraud, P. O., Romero, I. A., Hennig, B., and Toborek, M. (2008) Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells. Mol. Pharmacol. 73, 1424-1433.
25. Cucullo, L., Couraud, P. O., Weksler, B., Romero, I. A., Hossain, M., Rapp, E., and Janigro, D. (2008) Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J. Cereb. Blood Flow Metab. 28, 312-328.
26. Forster, C., Burek, M., Romero, I. A., Weksler, B., Couraud, P. O., and Drenckhahn, D. (2008) Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J. Physiol. 586, 1937-1949.
27. Wang, Y., Raine, A., Narr, K. L., Lencz, T., La Casse, L., Colletti, P., and Toga, A. W. (2001) Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim. Biophys. Acta 1513, 49-54.
28. Kennedy, M. D., Jallad, K. N., Lu, J., Low, P. S., and Ben-Amotz, D. (2003) Evaluation of folate conjugate uptake and transport by the choroid plexus of mice. Pharm. Res. 20, 714-719.
29. Weitman, S. D., Frazier, K. M., and Kamen, B. A. (1994) The folate receptor in central nervous system malignancies of childhood. J. Neur. Oncol. 21, 107-112.