Roles of dental pulp fibroblasts in the recognition of bacterium-related factors and subsequent development of pulpitis

Japanese Dental Science Review

Volumn 47, Issue 2, 2011, Pages 161-166

  Nakanishi, Tadashi ^a   Takegawa, Daisuke ^a   Hirao, Kouji ^a   Takahashi, Kanako ^a   Yumoto, Hiromichi ^a   Matsuo, Takashi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cytokine; Dental pulp fibroblast; Nucleotide binding oligomerization domain (NOD); Pulpitis; Toll like receptor (TLR)

Indexed keywords

EID: 79960746217     PISSN: 18827616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdsr.2011.02.001     Document Type: Review

References (70)

1. Jontell M., Gunraj M.N., Bergenholtz G. Immunocompetent cells in the normal dental pulp. J Dent Res 1987, 66:1149-1153.
2. Jontell M., Bergenholtz G., Scheynius A., Ambrose W. Dendritic cells and macrophages expressing class II antigens in the normal rat incisor pulp. J Dent Res 1988, 67:1263-1266.
3. Okiji T., Kawashima N., Kosaka T., Matsumoto A., Kobayashi C., Suda H. An immunohistochemical study of the distribution of immunocompetent cells, especially macrophages and Ia antigen-expressing cells of heterogeneous populations, in normal rat molar pulp. J Dent Res 1992, 71:1196-1202.
4. Okiji T., Jontell M., Belichenko P., Bergenholtz G., Dahlstrom A. Perivascular dendritic cells of the human dental pulp. Acta Physiol Scand 1997, 159:163-169.
5. Bergenholtz G., Nagaoka S., Jontell M. Class II antigen expressing cells in experimentally induced pulpitis. Int Endod J 1991, 24:8-14.
6. Dommisch H., Winter J., Acil Y., Dunsche A., Tiemann M., Jepsen S. Human beta-defensin (hBD-1, -2) expression in dental pulp. Oral Microbiol Immunol 2005, 20:163-166.
7. Huang G.T., Potente A.P., Kim J.W., Chugal N., Zhang X. Increased interleukin-8 expression in inflamed human dental pulps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999, 88:214-220.
8. Levin L.G., Rudd A., Bletsa A., Reisner H. Expression of IL-8 by cells of the odontoblast layer in vitro. Eur J Oral Sci 1999, 107:131-137.
9. Sloan A.J., Matthews J.B., Smith A.J. TGF-beta receptor expression in human odontoblasts and pulpal cells. Histochem J 1999, 31:565-569.
10. Piattelli A., Rubini C., Fioroni M., Tripodi D., Strocchi R. Transforming growth factor-beta 1 (TGF-beta 1) expression in normal healthy pulps and in those with irreversible pulpitis. Int Endod J 2004, 37:114-119.
11. Ohshima H., Nakakura-Ohshima K., Takeuchi K., Hoshino M., Takano Y., Maeda T. Pulpal regeneration after cavity preparation, with special reference to close spatio-relationships between odontoblasts and immunocompetent cells. Microsc Res Tech 2003, 60:483-490.
12. Hoshino E. Predominant obligate anaerobes in human carious dentin. J Dent Res 1985, 64:1195-1198.
13. Izumi T., Kobayashi I., Okamura K., Sakai H. Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth. Arch Oral Biol 1995, 40:609-614.
14. Hahn C.L., Best A.M., Tew J.G. Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun 2000, 68:6785-6789.
15. Martin F.E., Nadkarni M.A., Jacques N.A., Hunter N. Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis. J Clin Microbiol 2002, 40:1698-1704.
16. Hahn C.L., Falkler W.A., Siegel M.A. A study of T and B cells in pulpal pathosis. J Endodont 1989, 15:20-26.
17. D'Souza R., Brown L.R., Newland J.R., Levy B.M., Lachman L.B. Detection and characterization of interleukin-1 in human dental pulps. Arch Oral Biol 1989, 34:307-313.
18. Tani-Ishii N., Wang C.Y., Stashenko P. Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure. Oral Microbiol Immunol 1995, 10:213-219.
19. Rauschenberger C.R., Bailey J.C., Cootauco C.J. Detection of human IL-2 in normal and inflamed dental pulps. J Endodont 1997, 23:366-370.
20. Barkhordar R.A., Hayashi C., Hussain M.Z. Detection of interleukin-6 in human dental pulp and periapical lesions. Endod Dent Traumatol 1999, 15:26-27.
21. Nakanishi T., Matsuo T., Ebisu S. Quantitative analysis of immunoglobulins and inflammatory factors in human pulpal blood from exposed pulps. J Endodont 1995, 21:131-136.
22. Nakanishi T., Shimizu H., Hosokawa Y., Matsuo T. An immunohistological study on cyclooxygenase-2 in human dental pulp. J Endodont 2001, 27:385-388.
23. Nakanishi T., Takahashi K., Hosokawa Y., Adachi T., Nakae H., Matsuo T. Expression of macrophage inflammatory protein 3alpha in human inflamed dental pulp tissue. J Endodont 2005, 31:84-87.
24. Adachi T., Nakanishi T., Yumoto H., Hirao K., Takahashi K., Mukai K., et al. Caries-related bacteria and cytokines induce CXCL10 in dental pulp. J Dent Res 2007, 86:1217-1222.
25. Takahashi K., Nakanishi T., Yumoto H., Adachi T., Matsuo T. CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines. Oral Microbiol Immunol 2008, 23:320-327.
26. Warfvinge J. Morphometric analysis of teeth with inflamed pulp. J Dent Res 1987, 66:78-83.
27. Fitzgerald M., Chiego D.J., Heys D.R. Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth. Arch Oral Biol 1990, 35:707-715.
28. Goldberg M., Smith A.J. Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering. Crit Rev Oral Biol Med 2004, 15:13-27.
29. Nagaoka S., Tokuda M., Sakuta T., Taketoshi Y., Tamura M., Takada H., et al. Interleukin-8 gene expression by human dental pulp fibroblast in cultures stimulated with Prevotella intermedia lipopolysaccharide. J Endodont 1996, 22:9-12.
30. Hosoya S., Matsushima K. Stimulation of interleukin-1 beta production of human dental pulp cells by Porphyromonas endodontalis lipopolysaccharide. J Endodont 1997, 23:39-42.
31. Matsushima K., Ohbayashi E., Takeuchi H., Hosoya S., Abiko Y., Yamazaki M. Stimulation of interleukin-6 production in human dental pulp cells by peptidoglycans from Lactobacillus casei. J Endodont 1998, 24:252-255.
32. Tokuda M., Sakuta T., Fushuku A., Torii M., Nagaoka S. Regulation of interleukin-6 expression in human dental pulp cell cultures stimulated with Prevotella intermedia lipopolysaccharide. J Endodont 2001, 27:273-277.
33. Barkhordar R.A., Ghani Q.P., Russell T.R., Hussain M.Z. Interleukin-1beta activity and collagen synthesis in human dental pulp fibroblasts. J Endodont 2002, 28:157-159.
34. Yang L.C., Tsai C.H., Huang F.M., Liu C.M., Lai C.C., Chang Y.C. Induction of interleukin-6 gene expression by pro-inflammatory cytokines and black-pigmented bacteroides in human pulp cell cultures. Int Endod J 2003, 36:352-357.
35. Takeda K., Akira S. Toll-like receptors in innate immunity. Int Immunol 2005, 17:1-14.
36. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
37. Beutler B.A. TLRs and innate immunity. Blood 2009, 113:1399-1407.
38. Tapping R.I., Akashi S., Miyake K., Godowski P.J., Tobias P.S. Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol 2000, 165:5780-5787.
39. Aliprantis A.O., Yang R.B., Mark M.R., Suggett S., Devaux B., Radolf J.D., et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999, 285:736-739.
40. Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999, 274:17406-17409.
41. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001, 410:1099-1103.
42. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
43. Wang T., Town T., Alexopoulou L., Anderson J.F., Fikrig E., Flavell R.A. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004, 10:1366-1373.
44. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000, 408:740-745.
45. Coban C., Ishii K.J., Kawai T., Hemmi H., Sato S., Uematsu S., et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 2005, 201:19-25.
46. Ting J.P., Lovering R.C., Alnemri E.S., Bertin J., Boss J.M., Davis B.K., et al. The NLR gene family: a standard nomenclature. Immunity 2008, 28:285-287.
47. Yoneyama M., Fujita T. Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 2008, 29:178-181.
48. Girardin S.E., Travassos L.H., Herve M., Blanot D., Boneca I.G., Philpott D.J., et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003, 278:41702-41708.
49. Jiang H.W., Zhang W., Ren B.P., Zeng J.F., Ling J.Q. Expression of toll like receptor 4 in normal human odontoblasts and dental pulp tissue. J Endodont 2006, 32:747-751.
50. Veerayutthwilai O., Byers M.R., Pham T.T., Darveau R.P., Dale B.A. Differential regulation of immune responses by odontoblasts. Oral Microbiol Immunol 2007, 22:5-13.
51. Horst O.V., Tompkins K.A., Coats S.R., Braham P.H., Darveau R.P., Dale B.A. TGF-beta1 inhibits TLR-mediated odontoblast responses to oral bacteria. J Dent Res 2009, 88:333-338.
52. Mutoh N., Tani-Ishii N., Tsukinoki K., Chieda K., Watanabe K. Expression of Toll-like receptor 2 and 4 in dental pulp. J Endodont 2007, 33:1183-1186.
53. Durand S.H., Flacher V., Romeas A., Carrouel F., Colomb E., Vincent C., et al. Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts. J Immunol 2006, 176:2880-2887.
54. Staquet M.J., Durand S.H., Colomb E., Romeas A., Vincent C., Bleicher F., et al. Different roles of odontoblasts and fibroblasts in immunity. J Dent Res 2008, 87:256-261.
55. Keller J.F., Carrouel F., Colomb E., Durand S.H., Baudouin C., Msika P., et al. Toll-like receptor 2 activation by lipoteichoic acid induces differential production of pro-inflammatory cytokines in human odontoblasts, dental pulp fibroblasts and immature dendritic cells. Immunobiology 2010, 215:53-59.
56. He W., Yu Q., Zhou Z., Wang P. CpG oligonucleotides induce an immune response of odontoblasts through the TLR9, MyD88 and NF-kappaB pathways. Biochem Biophys Res Commun 2010, 399:274-278.
57. Lin Z.M., Song Z., Qin W., Li J., Li W.J., Zhu H.Y., et al. Expression of nucleotide-binding oligomerization domain 2 in normal human dental pulp cells and dental pulp tissues. J Endodont 2009, 35:838-842.
58. Matsushita K., Motani R., Sakuta T., Nagaoka S., Matsuyama T., Abeyama K., et al. Lipopolysaccharide enhances the production of vascular endothelial growth factor by human pulp cells in culture. Infect Immun 1999, 67:1633-1639.
59. Hirao K., Yumoto H., Takahashi K., Mukai K., Nakanishi T., Matsuo T. Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts. J Dent Res 2009, 88:762-767.
60. Park C., Lee S.Y., Kim H.J., Park K., Kim J.S., Lee S.J. Synergy of TLR2 and H1R on Cox-2 activation in pulpal cells. J Dent Res 2010, 89:180-185.
61. Botero T.M., Son J.S., Vodopyanov D., Hasegawa M., Shelburne C.E., Nor J.E. MAPK signaling is required for LPS-induced VEGF in pulp stem cells. J Dent Res 2010, 89:264-269.
62. Han J., Lee J.D., Bibbs L., Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994, 265:808-811.
63. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994, 369:156-160.
64. Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372:739-746.
65. Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002, 3:221-227.
66. Hirao K., Yumoto H., Nakanishi T., Mukai K., Takahashi K., Takegawa D., et al. Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells. Life Sci 2010, 86:654-660.
67. Fritz J.H., Girardin S.E., Fitting C., Werts C., Mengin-Lecreulx D., Caroff M., et al. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol 2005, 35:2459-2470.
68. Netea M.G., Ferwerda G., de Jong D.J., Jansen T., Jacobs L., Kramer M., et al. Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol 2005, 174:6518-6523.
69. Tada H., Aiba S., Shibata K., Ohteki T., Takada H. Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun 2005, 73:7967-7976.
70. Nakanishi T., Mukai K., Yumoto H., Hirao K., Hosokawa Y., Matsuo T. Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors. Eur J Oral Sci 2010, 118:145-150.